Glauprost 0.05% 2.5ml

Glauprost instruction for use

You can buy Glauprost eye drops here

Composition

In 1 ml of drops 50 μg of latanoprost.

Form of issue

Drops in a bottle of 2.5 ml and 5 ml.

pharmachologic effect

Reduces intraocular pressure.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Antiglaukomny drug, a synthetic analogue of prostaglandin F2α. On the one hand, it widens the vessels of the eye, activates the outflow of watery moisture and improves microcirculation, which normalizes intraocular pressure. On the other hand - regulates cellular metabolism, improves trophism of tissues, increasing the content of cAMP. This allows it to be used with open-angle glaucoma as a monotherapy drug.
Decrease in intraocular pressure is noted after 3-4 hours, and the total effect lasts 24 hours.

Pharmacokinetics

It penetrates through the cornea, hydrolyses to an active form. Cmax in aqueous humor is achieved 2 h after instillation. Metabolism occurs in the liver, in the tissues of the eye is almost not metabolized. Metabolites have little activity. It is excreted by the kidneys. The half-life is 17 min.

Indications for use

    Increased IOP (intraocular pressure);
    open angle glaucoma.

Contraindications of Glauprost

Hypersensitivity.
It is cautiously prescribed for aphakia, pseudoafaky with a capsular lens rupture, risk of macular edema, congenital glaucoma (no experience of use).

Side effects

    Pain in the eyes;
    a burning sensation in the eyes;
    blurring of vision;
    feeling of sand in the eyes;
    itching;
    swelling of the eyelids;
    blepharitis;
    lengthening of eyelashes and intensification of their pigmentation;
    hyperemia of the conjunctiva;
    change in iris pigmentation;
    darkening of the skin of the eyelids;
    dyspnea;
    dizziness;
    seizures of bronchial asthma;
    pain in the muscles and joints.

Glauprost, instructions for use (Method and dosage)

Bury in the eye for 1 drop 1 time in the evening. If the procedure is skipped, the next dose is administered at the scheduled time on the next day, without doubling it.
The use of the drug causes a change in eye color due to the increase in brown pigment. It is usually seen in individuals with a mixed color of the iris. With intensive changes in pigmentation, treatment is discontinued. Patients who use drops in one eye may experience heterochromia. The doctor informs the patient about the probability of changing the color of the eyes. Changes in eyelashes in the form of lengthening and thickening pass after the end of treatment.
If other eye drops are prescribed, they should be administered at intervals of 5 minutes. Before the procedure, the contact lenses are removed and inserted after 15 minutes.

Overdose

Overdose is manifested by symptoms: hyperemia, irritation of the eye mucosa. Symptomatic therapy is performed.

Interaction

Simultaneous use of other analogues of prostaglandins causes a paradoxical increase in pressure in the eye. Pharmaceutically incompatible with thiomersal (precipitation occurs). When used with timolol, pilocarpine, adrenomimetics, an additive effect on intraocular pressure is noted.

Storage conditions

The temperature is from 2 ° to 8 ° C. Open the vial at room temperature and use for a month.
Shelf life - 2 years.

Reviews about Glauprost

According to the results of the research, eye drops of Glauprost in patients with an intraocular pressure level of 24-25 mm Hg. Art. reduced it by 6-8 mm Hg. Art. If we compare its effectiveness with a solution of timolol, then one instillation of Glauprost is equivalent to a 2-fold application of timolol per day. This drug has a longer and more pronounced hypotensive effect, as evidenced by the patient's feedback.
    "... Glauprost is happy that you can only drip once a day. The treatment is well tolerated, there is no irritation. "
    "... These drops are used by the husband, they help well, but six months later they noticed a change in the color of the eyes. The doctor did not warn us, so we panicked. "
    "... They help well, but they are expensive, given that the treatment of glaucoma is lifelong."
In negative reviews there are side effects in the form of redness and rubbing in the eyes, intolerable itching and conjunctivitis, because of which the drug was canceled. High costs are also noted.