Luxfen drops 5ml

Eyes drops Luxfen instruction for use

You can buy Luxfen on this page

Structure

1 ml contains:
Active ingredient of Luxfen: Brimonidine tartrate 2.0 mg
Excipients: benzalkonium chloride (in terms of 100% substance) - 0.052 mg, polyvinyl alcohol - 14.0 mg, sodium chloride - 6.90 mg, sodium citrate dihydrate - 4.70 mg, citric acid monohydrate 0.48 mg , hydrochloric acid - up to pH 6.45, sodium hydroxide - up to pH 6.45, water - up to 1 ml.

Description

Transparent solution of greenish-yellow color

Pharmacotherapeutic group

Antiglaucoma means - alpha 2-adrenomimetic selective
ATX Code: S01ЕA05

pharmachologic effect

Pharmacodynamics

Brimonidine is a selective α 2 -adrenoreceptor agonist. When instillation 0.2% brimonidine solution, the decrease in intraocular pressure is 10-12 mm. gt; The maximum effect is noted after 2 hours, the duration of the action is 12 hours.
Brimonidine has a dual mechanism of action, it can lower intraocular pressure by reducing the synthesis of intraocular fluid and enhancing the uveoscleral outflow.

Pharmacokinetics

After applying 0.2% solution of eye drops of brimonidine twice a day for 10 days, its plasma concentration remains low (on average 0.06 ng / ml).
When instillation of eye drops the maximum concentration of the drug in the blood plasma is reached after 0.5-2.5 h, the half-life period (T1 / 2) is about 2 hours.
The connection with blood proteins with topical application is 29%.
The systemic absorption of brimonidine is slowed down.
Luxfen is metabolized primarily in the liver. Brimonidine and its metabolites are excreted by the kidneys.

Indications for use

Open angle glaucoma, ophthalmic hypertension (in monotherapy and in combination with other drugs that reduce intraocular pressure).

Contraindications for Luxfen

    Hypersensitivity to the components of the drug.
    Simultaneous therapy with monoamine oxidase (MAO) inhibitors and tricyclic antidepressants.
    Children up to 2 years.
    The period of breastfeeding.

Carefully:

When using Luxfen in patients with severe, unstable and uncontrolled form of cardiovascular disease, with cerebral or coronary insufficiency, depression, orthostatic hypotension, Raynaud's disease, obliterating thromboangiitis; if the liver or kidney function is impaired; children age from 2 to 18 years.
Application in pregnancy and during breastfeeding
Studies of the safety and efficacy of brimonidine in pregnant and lactating women have not been conducted. In animal studies, the local use of brimonidine did not lead to a disruption of intrauterine development. There is no precise data on the penetration of brimonidine in breast milk in topical application. However, the risk can not be ruled out completely. The use of brimonidine in pregnancy is allowed only in cases where the expected benefit to the mother exceeds the potential risk to the fetus or child. When appointing during lactation, breastfeeding should be stopped for the duration of treatment.

Dosing and Administration

Locally.
Bury 1 drop of the drug 2 times a day.
The duration of treatment is determined by the doctor.

Side effects of Luxfen

The incidence of side effects is classified as follows:
very often (> 1/10),
often (> 1/100 to sometimes (> 1/1000 to rare (> 1/10 000 to very rare (frequency unknown (side effects with unknown frequency)
On the part of the organs of vision:
very often - allergic conjunctivitis, conjunctival hyperemia, itchy eyelid skin and eye mucosa;
often - burning sensation, folliculosis conjunctiva and follicular conjunctivitis, local allergic mucosa reaction eye (including keratoconjunctivitis), blepharitis, blepharoconjunctivitis, impaired clarity of vision, cataract, conjunctival edema, hemorrhage in the conjunctiva, conjunctivitis, epiphora, mucus from the eyes, dryness and irritation of the eye mucosa, pain, swelling of the eyelids, redness of the eyelids, sensation of foreign body in the eyes, keratitis, lesion of the eyelids, photosensitivity, acute spotted keratopathy, lachrymation, loss of field of vision, functional damage to the vitreous humor, vitreous hemorrhage, floating opacities in the vitreous and decreased visual acuity;
infrequently - the erosion of the cornea, barley.
From the central nervous system:
often - headache, drowsiness, insomnia, dizziness.
From the cardiovascular system:
often - increased blood pressure;
infrequently - lowering blood pressure.
On the part of the respiratory system:
often - bronchitis, cough, shortness of breath;
infrequently - dryness of the nasal mucosa; apnea.
From the gastrointestinal tract:
often - gastrointestinal disorders - dyspepsia, dryness of the oral mucosa.
From the skin and subcutaneous fat:
often - rashes.
Infectious and parasitic diseases:
often - influenza-like syndrome, infectious disease (chills and respiratory infection), rhinitis, sinusitis, including infectious.
Laboratory indicators:
often - hypercholesterolemia.
Others:
often - general allergic reactions, asthenia, fatigue;
infrequently - a change in taste.
Children are marked with:
apnea, bradycardia, lowering blood pressure, hypothermia, muscle hypotension.
In addition, data on the following effects were obtained:
On the part of the organs of vision:
frequency unknown - iritis, keratoconjunctivitis, miosis.
From the central nervous system:
depression.
From the cardiovascular system:
bradycardia, tachycardia.
From the gastrointestinal tract:
nausea.
From the skin and subcutaneous fat:
local skin reactions (erythema, itching, face swelling, rash and vasodilation of the eyelid skin vessels).

Overdose with Luxfen

Overdose is extremely rare.
With the occasional intake of the drug inside, the following symptoms are possible: depression of the central nervous system, drowsiness, depression and loss of consciousness, lowering of blood pressure, bradycardia, lower body temperature, cyanosis of the skin, apnea.
At casual reception of a preparation inside: supporting symptomatic therapy, the control of patency of respiratory ways.

Interaction Luxfen with other drugs

Brimonidine in a concentration of 2 mg / ml can enhance the effect of substances that affect the central nervous system (alcohol, barbiturates, opioids, sedatives and anesthetics).
Care should be taken in the case of drugs that can affect the absorption into the blood and metabolism of adrenaline, noradrenaline and other so-called biogenic amines (chlorpromazine, methylphenidate, reserpine).
In some patients, after a brimonidine solution at a concentration of 2 mg / ml, there is a slight decrease in blood pressure. Caution should be exercised when using a combination of cardiac glycosides (digitalis) with antihypertensive drugs and / or drugs.
With simultaneous systemic administration of agonists or antagonists of adrenoreceptors (for example, isoprenaline or prazosin) for the first time, as well as changing the dose of these simultaneously administered systemic preparations (regardless of the mode of administration), interactions with alpha-adrenergic agonists or effects on their effects may occur .

special instructions for Luxfen

Before using Luxfen, contact lenses should be removed. The time interval between use of the drug and the re-installation of contact lenses should be at least 15 minutes.
Influence on the management of vehicles and the implementation of potentially hazardous activities
Luxfen can cause fatigue or drowsiness, reduced vision, so during drug treatment should refrain from driving vehicles and servicing moving mechanisms.

Form of issue

Eye drops 0.2%.
5 ml in bottles of white color from low-density polyethylene with a transparent drip-nozzle made of low-density polyethylene and a white screw cap made of high-density polyethylene with control of the first opening. A label is attached to the vial.
1 bottle together with the instruction for use is placed in a cardboard box.

Storage conditions

Store at a temperature not exceeding 25 ° C.
Keep out of the reach of children.
Shelf life - 2 years. Do not use after the expiration date.
Shelf life after opening the bottle is 4 weeks.

Conditions of leave from pharmacies

To buy Luxfen the prescription is not needed.