Nevanac 0.1% 5ml

Nevanac instruction

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Composition

In 1 ml of napafenac, 1 mg.
Benzalkonium chloride, carbomer, tyloxapol, disodium edetate, mannitol, sodium chloride, water, as auxiliary substances.

Form of issue

Drops, suspension in a vial-dropper 5 ml.

pharmachologic effect

Anti-inflammatory (for use in ophthalmology).

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The active substance is a non-steroidal anti-inflammatory drug that has an anti-inflammatory and analgesic effect. It penetrates through the cornea and turns into an active form - amfenac, which inhibits the enzyme necessary for the production of prostaglandins. The use of the drug reduces pain and swelling of the eye tissues, without affecting the intraocular pressure.

Pharmacokinetics

Quickly absorbed with topical application. After daily use, low concentrations of active substance are detected in the blood after 2 hours. Cmax of napafenac in the aqueous humor of the eye is noted after 1 hour. The active substance has a high affinity for albumins and binding to them is 99%. Under the action of enzymes, it undergoes hydrolysis to amphenac, which subsequently forms conjugates with glucuronic acid. In studies after oral administration, it was excreted by the kidneys (about 85%) and through the intestine (6%).

Indications for use

Treatment of pain and inflammation after surgery (removal of cataracts).

Contraindications of Nevanac

    "Aspirin" bronchial asthma, acute rhinitis with NSAIDs;
    age to 18 years (since safety of application was not investigated);
    pregnancy (reproductive toxicity established during animal testing);
    hypersensitivity.

Side effects

Systemic side effects:

    headache;
    nausea, vomiting,
    increased blood pressure;
    sinusitis;
    dry mouth.

Local reactions:

    point keratitis;
    hyperemia of the conjunctiva and its dryness;
    itching of the eyes;
    blurred vision;
    Pain in the eyes;
    iritis, keratitis;
    irritation and discharge from the eyes;
    photophobia;
    increased tearing.
In case of signs of corneal damage (corneal opacity, epithelial defect), the drug should be discontinued, as this creates a threat of vision loss.

Nevanac, instructions for use (Method and dosage)

Drops are applied topically 1 drop in the eye 3 times a day. Treatment is started before cataract surgery for 1 day and is performed within 2 weeks after the operation. 30 minutes before the operation, the drug is additionally applied. Before use, the vial is shaken. During treatment, avoid exposure to the sun.
Long-term use increases the risk of unwanted reactions from the cornea. The content of the preservative preparation causes irritation and discoloration of contact lenses. Wearing contact lenses during treatment is not recommended. The drug is used with caution in patients with a history of bleeding, since application after surgery can cause it.

Overdose

No information. In case of accidental ingestion of a large amount of the drug, it is necessary to rinse the eyes with water.

Interaction

Studies have shown that the drug does not inhibit the activity of cytochrome P450, so there is no interaction with drugs that transform with the involvement of cytochrome P450. The simultaneous use of this drug and Prostaglandin or its analogues is not recommended, since there are no data on their simultaneous use. When used in combination with other drugs, the interval between instillation should be observed for 5 minutes.

Storage conditions

The temperature does not exceed 25 ° C.
Shelf life - 2 years.

Reviews about Nevanac

There are few reviews from patients who used eye drops Nevanac. In most cases, they are associated with the presence of adverse reactions in the form of burning, pain and itching in the eye, dryness of the conjunctiva, sensation of the foreign body. Systemic side effects were less common: nausea, headache, and increased blood pressure. For this reason, the use of the drug in many patients was canceled.