Buserelin spray 0.15mg/dose 17.5ml 187doses

Buserelin instruction

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Composition

One bottle contains 150 μg of buserelin acetate. 1 dose of the spray includes 2.1 mg of buserelin acetate. Additional substances: water, benzalkonium chloride.

Form of issue

Spray Buserelin is a colorless transparent solution that does not contain any inclusions. 17,5 ml of solution in a glass bottle - 1 bottle with stopper pump for dosing in a cardboard box.

pharmachologic effect

Antigonadotropic, anti-estrogenic, anti-androgenic action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

An artificial analog of natural gonadoliberin. Competitively reacts with receptors of pituitary cells, provoking a short-term increase in the content of sex hormones in the blood.
The use of the drug in therapeutic doses causes (about 2 weeks later) total blocking of the gonadotropic function of the anterior pituitary, inhibiting the release of lyutenizing and follicle-stimulating hormone. The consequence of this is the suppression of the biosynthesis of sex hormones in the tissues of the ovaries and a decrease in the content of estradiol in plasma before postmenopausal indicators.

Pharmacokinetics

With the intranasal route of administration, the drug is completely adsorbed through the nasal mucosa. The half-life is approximately 3 hours.
In small quantities it is possible to excrete with milk during lactation.

Indications for use

Hormone-dependent diseases of the reproductive system caused by hyperestrogenism, both absolute and relative:
    uterine myoma;
    endometriosis (preoperative and postoperative periods);
    infertility therapy (with in vitro fertilization);
    hyperplastic processes in the tissues of the endometrium.

Contraindications

    pregnancy and lactation;
    allergy to drug components.
Spray Buserelin should be used with caution in diabetes, arterial hypertension, depression.

Side effects

    Reactions from the nervous activity: nervousness, headache, fatigue, dizziness, sleep disturbance, memory impairment and concentration of attention, drowsiness, development of depression, emotional lability.
    Reactions from sensory organs: deterioration of hearing and vision, tinnitus, a feeling of pressure in the eyes.
    Reactions from the hormonal sphere: increased sweating, "tides" of blood to the face and chest, decreased libido, vaginal dryness, pain in the lower abdomen, menstrual bleeding, demineralization of bones.
    Reactions from the circulation: palpitation, increase in blood pressure.
    Allergic reactions: anaphylactic shock, pruritus, urticaria, bronchospasm, skin hyperemia, Quincke's edema.
    Reactions on the part of digestion: a violation of appetite, vomiting, nausea, thirst, constipation, diarrhea, weight change.
    Reactions from laboratory data: hyperglycemia, lipid spectrum disorders, decreased glucose tolerance, increased serum transaminase levels, thrombocytopenia, leukopenia, hyperbilirubinemia.
    Common reactions: pulmonary embolism, nasal bleeding, weakening or stimulation of hair growth on the body and head, swelling of the ankles and feet, back pain, arthralgia.
    Local reactions: pain and dryness in the nose, irritation of the mucous membranes of the nose.

Instructions for Buserelin (Method and dosage)

Spray Buserelin is sprayed strictly in the nasal passages of the field of their preliminary sanation (cleansing).

Spray Buserelin, instructions for use

In the treatment of uterine fibroids, hyperplastic processes in the tissues of the endometrium, endometriosis, the drug is sprayed into the nasal passages at a dose of 900 μg per day. A single dose with a single push on the pump is 150 mcg. The daily dose is injected in equal parts with one spray into each nasal passage three times a day every 6-8 hours (in the afternoon, in the morning and in the evening.) It is recommended to start Buserelin therapy on the first or second day of the menstrual cycle and then continuously continue it. -6 months usual duration of the standard course of treatment.
In the treatment of infertility (in vitro fertilization), the drug is sprayed intranasally once (150 μg) into each nasal passage 3-4 times a day every 6-8 hours. The standard dose is 900-1200 mcg per day. The drug is prescribed on the 2nd day or on the 21-24 day of the cycle, which precedes the stimulation. After 15-17 days in the absence of cysts in the ovaries, a decrease in the concentration of estradiol in the blood, not less than half of the initial value, the thickness of the endometrium to 5 mm, causes superovulation with the help of gonadotropic hormones under the supervision of ultrasound and monitoring the content of estradiol in the blood. If necessary, the dosage of the drug is adjusted.

Overdose

There are no data on cases of drug overdose.

Interaction

Simultaneous appointment with other means, including sex hormones, can provoke the development of ovarian hyperstimulation syndrome.
When combined, can with hypoglycemic agents may weaken their activity.

Storage conditions

Store in a dark place at a temperature of 8-25 ° C. Keep away from children.
Shelf life - Three years.

special instructions

Patients with depression during treatment should be under the close supervision of a physician.
Stimulation of ovulation should be carried out only under medical supervision.
At the beginning of treatment with the drug, the appearance of an ovarian cyst is not ruled out.
In persons using contact lenses, there may be signs of irritation of the conjunctiva.
The second course of therapy is allowed to begin only after a careful assessment of the suitability of the expected benefit and the risk of osteoporosis.
Intranasal administration of the drug does not exclude the development of irritation of the mucous nose, nosebleeds. The medicine can be used in rhinitis, but before using it, it is recommended to clean the nasal cavity.
The use of Buserelin together with surgical intervention in endometriosis reduces the magnitude of pathological foci and their perfusion, inflammation and shortens the duration of the operation, and postoperative treatment improves the results, reducing the frequency of relapses and preventing the formation of adhesions.
Before starting treatment, you must exclude pregnancy and stop taking any hormonal contraceptives, but during the first 2 months of taking the drug, you should use other methods of contraception.
It is recommended to be careful when driving during the treatment period.

Children

The drug is not used in children.

Buserelin and alcohol

Taking alcohol while using any medicines can cause side effects to increase, so do not combine these drugs.

In pregnancy and lactation

It is forbidden to use this product during pregnancy and lactation.

Reviews of Buserelin

Reviews about the spray Buserelin have a large amplitude of estimates. There are patients who have been helped, but there are many reports of side effects, including cysts. The doctors' comments on the spray indicate that this remedy can be used only with the availability of qualified medical supervision.