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Clostilbegyt 50mg #10

  • $32.77
  • 3 or more $29.90
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Clostilbegyt instruction for useReed more and buy Clostilbegyt hereTablets Clostilbegyt refer to the clinical and pharmacological group of medicines stimulants of the production of gonadotropic hormones of the pituitary gland. The..

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Clostilbegyt instruction for use

Reed more and buy Clostilbegyt here

Tablets Clostilbegyt refer to the clinical and pharmacological group of medicines stimulants of the production of gonadotropic hormones of the pituitary gland. They are used for complex treatment of the pathology of the sexual and endocrine system, which consists in the violation of hormone production.

Form of issue and composition

The drug Clostilbegyt is available in the form of a tablet for oral administration (oral administration). They have white, light yellow or light gray color, rounded shape and biconvex surface. The main active substance of the drug is clomiphene in the form of acetate. Its content in one tablet is 50 mg. It also includes auxiliary components, which include:
    Magnesium stearate.
    Stearic acid.
    Potato starch.
    Lactose monohydrate.
Tablets are packaged in 10 pieces in a blister or in a vial of dark glass. A cardboard pack contains one blister or a bottle with tablets and instructions for the use of the drug.

pharmachologic effect

The active substance is an anti-estrogenic compound not of a steroid structure. The mechanism of action of clomiphene is the effect on specific estrogen receptors, localized in the ovary of a woman and the pituitary gland. With a high estrogen content in the body, the drug exhibits a pronounced anti-estrogenic effect, reversibly suppresses their synthesis by ovarian cells. With a slight increase or decrease in the level of estrogens, the active substance of the drug has an opposite, estrogenic effect. In small doses, the drug enhances the secretion of gonadotropins in the pituitary gland and stimulates the process of ovulation (the exit of a mature egg from the ovary), with the use of high doses inhibits their secretion and, accordingly, ovulation. The drug does not possess gestagenic and androgenic activity, does not lead to the development of secondary sexual characteristics and does not affect the level of gestagens, which are produced by the yellow body of the ovary.
After taking Clostilbegyt pill inside, the active substance is absorbed well and quickly from the intestine. Clomiphene is distributed uniformly in all tissues of the body, it is metabolized in the liver to inactive decay products, which are excreted primarily with bile. The half-life (the time of elimination of half of the entire dose of the drug) averages 5-7 in the afternoon.

Indications for use

Reception of tablets Clostilbegyt is indicated for complex treatment of the pathology of the sexual system of the woman's body, which is accompanied by a violation of the balance of sex hormones and gonadotropin. Such diseases include:
    Amenorrhea (absence of menstruation), caused by a violation of the level of gonadotropin and its regulatory effect on the genitals (disgonadotropic form of amenorrhea).
    Postcontraceptive amenorrhea - the absence of menstruation after the use of oral hormonal contraceptives.
    Anovulatory infertility - the drug is used to induce the process of ovulation.
    Secondary amenorrhea due to violation of the level of sex hormones in the body of a woman.
    Oligomenorea - a decrease in the severity of menstrual bleeding, as well as the duration of menstruation.
    Galactorrhea - the appearance and excretion of breast milk in a woman against the background of the development of the hormone producing tumor of the pituitary gland.
    Stein-Levental Syndrome - polycystic ovary (formation of a large number of formations filled with serous fluid, resulting in a significant impairment of the functional activity of the ovary).
    Chiari-Frommel syndrome - prolonged postpartum amenorrhea and galactorrhea (excretion of breast milk).
Also, the drug can be used to treat androgen deficiency (insufficient level of male sex hormones) and oligospermia (decrease in the number of spermatozoa per unit volume of ejaculate) in men.

Contraindications for use

Reception of tablets Clostilbegyt is contraindicated in a number of pathological and physiological conditions of the body, which include:
    Individual intolerance of the active ingredient or auxiliary components of the drug.
    Metroragia (uterine bleeding) of unexplained origin.
    Disturbance of the functional activity of the adrenal glands.
    Pronounced hepatic or renal insufficiency.
    Tumor process or pathology of the pituitary gland, accompanied by a change in its functional state.
    Visual disturbances that developed recently or were long ago.
    Any neoplasms (including benign) of the genitals.
    Endometriosis is a pathology that is characterized by the formation of ectopic foci of the endometrium (mucous membrane of the uterus) with their localization in other organs of the reproductive system or various systems of the female body.
    Insufficient functional activity of the adrenal glands on the background of increased production of prolactin (hyperprolactinemia).
    Changes in the functional activity of the thyroid gland.
    Pregnancy at any time of its course.
    Lactose intolerance, which is an auxiliary component of the drug - glucose-galactose malabsorption, galactose intolerance, lactase deficiency.
Before starting treatment with Clostilbegyt, you should make sure that there are no contraindications.

Dosing and Administration

Clostilbegyt tablets are taken orally, wholly, after intake they are washed down with a sufficient amount of water. Dosage and mode of taking the drug depend on the pathological process for the treatment of which it is applied:
    To treat infertility patients with regular menstrual cycles, the drug is used at a dose of 50 mg 1 time per day starting from the 5th day of the menstrual cycle. Simultaneous monitoring of clinical and laboratory indicators of the effectiveness of therapy is carried out. In case of concomitant absence of menstruation (amenorrhea), the beginning of treatment with Clostilbegyt tablets starts any day. There are 2 schemes of infertility treatment - 50 mg once a day for 5 days, after the end of this period of time, ovulation should occur. In the absence of it, the treatment is carried out using a second scheme, which includes taking the drug at a dose of 100 mg from the 5th day of the menstrual cycle also for 5 days. In the absence of menstruation, taking pills is interrupted for 3 months, after which a repeated course of treatment is carried out according to the same scheme. If the third course of treatment with Clostilbegyt tablets does not bring a therapeutic effect and ovulation has not resumed, then its subsequent use is inexpedient.
    Treatment of polycystic ovary syndrome - 50 mg per day, the doctor determines the course of treatment individually.
    Postcontraceptive amenorrhea - reception of tablets Clostilbegyt is carried out according to the same scheme as during the infertility treatment against the background of the absence of ovulation.
A man for the treatment of oligosperption is used in a dose of 50 mg 1-2 times a day for 6 weeks, during the period of periodic laboratory monitoring of the spermogram.

Side effects

After the beginning of the use of the Clostilbegyt tablets, it is possible to develop side effects from various organs and systems:
    Digestive system - nausea, rarely abdominal pain with predominant localization in the stomach, flatulence (bloating), increased appetite, manifestations resembling the surgical syndrome of an acute abdomen.
    Nervous system - headache, dizziness, less often - slowing of mental reactions, depression, increased nervous excitability, insomnia.
    Organs of the senses - visual disturbances in the form of blurriness of contours of objects, double vision, photophobia.
    Sexual system - pain of the internal genital area (lower abdomen in women), dryness of the vaginal mucosa.
    Urinary system - increase in the number of urination with increased volume of excreted urine (polyuria).
    Endocrine system - dysmenorrhea (irregular menstrual cycle), densification of the mammary glands, their soreness, hormonal uterine bleeding, enlarged ovaries in size.
    Skin and its appendages - alopecia (hair loss).
    Metabolism - increase or decrease in body weight.
    Allergic reactions develop rarely in the form of allergic dermatitis (rash, itchy skin, hives, reminiscent of nettle burn), vasomotor reactions (allergic rhinitis).
Treatment with tablets Clostilbegyt during subsequent pregnancy can lead to the development of multiple pregnancies. Also, against the background of taking the drug, it is possible to develop a sensation of "hot flashes" to the skin of the face, which disappear after the abolition of the Clostilbegyt tablets. The development of side effects is the basis for lowering the dosage or canceling the drug.

special instructions

Before you start taking Clostilbegyt tablets, you should carefully read the annotation to the drug. There are a few special instructions that include:
    Before starting the use of the drug, it is important to conduct a laboratory study of indicators of the functional activity of the liver.
    Before the course of therapy, a gynecological examination with a gonadotropin level in the urine is mandatory.
    The increase in the size of the ovaries or the suspected development of polycystosis is the basis for the withdrawal of the drug.
    During the application of the drug, a periodic examination of the gynecologist's doctor is carried out, which monitors the functional activity of the ovaries, and carries out vaginal examinations.
    During treatment of infertility after conception, a prophylactic course of progesterone is recommended.
    Receiving tablets Clostilbegyt increases the likelihood of multiple pregnancy.
    The drug does not have a direct effect on the functional activity of the cerebral cortex, however, in connection with the possible development of side effects from the central nervous system during its reception, it is not recommended to perform work associated with the need for increased concentration of attention and speed of psychomotor reactions.
In the pharmacy network, Clostilbegyt tablets are dispensed only on prescription. It is not recommended their independent use or reception on the advice of third parties.


A significant excess of the recommended therapeutic dose of the tablets Clostilbegyt leads to the development of symptoms of overdose in the form of nausea, vasomotor reactions, the appearance of "hot flashes", enlargement of the ovaries in size, visual impairment (sharp decrease in its severity). In such cases, washing of the stomach, intestines, intake of intestinal sorbents (activated charcoal or analogues), as well as symptomatic and intravenous-drop detoxification of the organism are performed. Data on the effectiveness of hemodialysis (hardware purification of blood) with an overdose of Clostilbegyt tablets is not available today.

Terms and conditions of storage

The shelf life of the Clostilbegyt tablets is 5 years. They should be stored in a dry place inaccessible to children at an air temperature of +15 to + 25ÂșC.

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