Dydrogesterone 10mg #20

Instruction for Dydrogesterone

You can buy Duphaston here

Composition

Abstract indicates that the composition of Duphaston contains active ingredient dydrogesterone, as well as auxiliary substances: corn starch, lactose monohydrate, methyl hydroxypropylcellulose, dye, magnesium stearate, anhydrous colloidal silicon dioxide.

Form of issue

The preparation is given in the form of tablets 10 mg No. 10 biconvex, round. Tablets of white color have beveled edges, they are covered with a shell. On one side of the tablet there is an engraving "S" above the sign "6", on the other side - a risk and the sign "155" on both sides. In total, the blister contains 20 tablets, one blister is embedded in a cardboard box.

pharmachologic effect

The active component of the drug dydrogesterone is an analog of natural progesterone. Duphaston is a hormonal drug.
Under the influence of this drug in the body of a woman there is no violation of thermogenesis, so the basal temperature can be measured to determine ovulation. The agent has no effect on metabolic processes in the body, on liver function. Dydrogesterone by its properties and structure is very similar to natural progesterone. Nevertheless, the remedy does not provoke manifestations of those side effects that arise when taking a number of synthetic progesterones. Wikipedia testifies that this drug does not have an androgenic, estrogenic, anabolic, thermogenic, corticoid effect. As a component of hormone replacement therapy for menopause, medicine provides a positive effect of estrogens on the lipid profile of a woman's blood. But if estrogens have a negative effect on the process of blood coagulation, then dydrogesterone has no effect on coagulation.
When administered, the selective effect of dydrogesterone on the endometrium is noted, which helps to prevent a high risk of manifestations of endometrial hyperplasia or carcinogenesis provoked by increased production of estrogens. The medicine does not have a contraceptive effect. During treatment, the drug does not affect ovulation. Monthly at reception of means also continue on a usual cycle. A woman can get pregnant with dydrogesterone and keep the pregnancy in the process of treatment by means, as during treatment there is no negative effect on the fetus. There is a selective effect on the progestin receptors of the uterine mucosa. Ovulation of the follicle is not affected. There is no masculinizing and virilizing effect.
Since the natural hormone, dydrogesterone reduces the level of excitability of the myometrium, under its influence the contractile activity of the uterus decreases. Unequivocal is the answer to the question of whether this weight affects the weight: taking Duphaston does not contribute to a set of extra pounds.
Thus, dydrogesterone reduces the effect of natural estrogens on the body, so it is successfully used in infertility, with PMS, habitual miscarriage, with menopause, in women who have already had a frozen pregnancy, etc.

Pharmacokinetics and pharmacodynamics

After oral administration, rapid absorption of dydrogesterone from the digestive tract takes place, after 2 hours the maximum concentration of the active component in the blood is noted. The degree of binding to blood proteins is 97%. Out of the body, 56-79% are excreted by the kidneys, about 85% are removed from the body a day after taking it, the entire elimination process is completely completed after 72 hours. In the urine there are metabolites, mainly in the form of glucuronic acid conjugates.
There is no evidence of a change in the pharmacokinetics and pharmacodynamics of the active component in people who suffer from kidney disease. Not cumulated.

Indications for use

Why pills Duphaston appointed, depends on the diagnosis and treatment scheme, which determines the doctor.
Currently, the following indications for the use of the drug are determined:
    Insufficiency of progesterone in the body (with infertility associated with insufficiency of the luteal phase, with a threat of miscarriage or a habitual loss of the fetus, with dysmenorrhea, violations of the monthly cycle, amenorrhea secondary genesis).
    Within the framework of hormone replacement therapy (when menopause is used to neutralize the proliferative effect of estrogens on the uterine lining of the uterus when using estrogens, with surgical castration).
Thus, tablets are prescribed for dysfunctional uterine bleeding, with polycystic ovaries, with a yellow body cyst, with endometrium, with uterine myomas.
From what the medicine is prescribed yet, when it is prescribed, and what dosage should be, it is necessary to ask the attending physician.

Contraindications

There are contraindications for taking Duphaston.
First of all, you can not drink tablets with high sensitivity to dydrogesterone or to other components of the medication, as this can harm a woman's body.
Caution tablets are prescribed for women who have suffered from itching during pregnancy before.
There is no evidence of a negative effect of dydrogesterone on people who suffer from renal failure in chronic form.

Side Effects of Duphaston

In the process of admission, there may be some side effects of Duphaston:
    immune system: hypersensitivity (very rarely);
    hemopoietic system: hemolytic anemia (isolated cases);
    nervous system: migraine, headache;
    Hepatobiliary system: minor violations of liver function, which may manifest weakness, jaundice, abdominal pain;
    reproductive system: breakthrough bleeding when taken (rarely), prevented by an increase in the dosage of the drug; can increase the sensitivity of the mammary glands;
    subcutaneous tissue, skin: itching, hives (rarely), Quincke's edema (very rarely);
    general disorders: peripheral edema (very rare).
If any of these symptoms occur, tell the doctor that this side effect is taking place.

Instructions for use Duphaston (Method and dosage)

The drug is prescribed according to the individual scheme, as in the planning of pregnancy, and with gynecological diseases. How to take, before meals or after, does not matter.

Duphaston tablets, instructions for use

These reception schemes are only indicative. To prescribe a therapy regimen, determine how long it takes to take the pill, the doctor must take into account the symptoms of the illness, the phases of the monthly cycle. The daily dose of the drug should be divided into 2-3 doses, you need to drink the pills at regular intervals.
Duphaston in endometriosis is prescribed in a dose of 10 mg of dydrogesterone 2 or 3 times a day. How to take Duphaston in endometriosis, depends on the appointment of a doctor. Take the drug from the 5th to the 25th day of the cycle or do it without interrupion. It should be borne in mind that only the attending physician can appoint Duphaston in endometriosis. Doctors' reviews on the Internet or any medical forum with information about treatment should be taken only as information for familiarization.
Duphaston for conception with infertility progesterone genesis is prescribed from 11 to 25 day of the monthly cycle. How to take Duphaston for conception, you must always find out from a specialist. As a rule, the reception lasts for 3-6 months. How to take Duphaston to get pregnant, how much to drink to get pregnant, depends on the diagnosis of a woman, the individual characteristics of her body.
If there is a delay after taking the pill and there are other signs of pregnancy while taking the drug, the treatment should continue, and the dose should be the same as that prescribed for the usual loss of pregnancy.
If a woman has a threat of miscarriage or a habitual loss of pregnancy, it is advisable to use the medicine only if there is clear evidence of a deficiency of endogenous progesterone. Women with a threatening abortion are shown a single dose of dydrogesterone 40 mg, then within a week should take 10 mg every 8 hours. Further, the dose gradually decreases. But if again there is a threat of abortion, the dose is increased. The application can be practiced until the 20th week of pregnancy. But more specifically about how to take a week before pregnancy tablets, the doctor will consult individually.
How to take when a threat of miscarriage in the early stages, the doctor determines individually. Usually, with the habitual miscarriage at the stage of pregnancy planning, Duphaston is administered on the 11th-25th day of the cycle, provided that conception has occurred, the woman continues to receive the same dose. Further, after the 20th week of pregnancy, the dose should be gradually reduced.
For women suffering from PMS, tablets are administered from 11 to 25 days for 10 mg, the treatment lasts from 3 to 6 months.
Duphaston with a delay of menstruation, with an irregular cycle and other violations of menstruation appoint from 11 to 25 cycles, 2 times a day for 20 mg. How to cause a month-long Duphaston, depends on the diagnosis of a woman. The doctor prescribes the medication with an irregular cycle, determines how to take Duphaston to cause the monthly, how many to drink, to trigger the menstrual cycle. Whether it is possible to induce a period in amenorrhoea depends on the correctness of the treatment. As a rule, the reception of Duphaston in this case is combined with the use of estrogens. Such treatment should be practiced for at least three monthly cycles.
In the case of dysfunctional bleeding appoint a drug of 10 mg twice daily for 5-7 days, combining the intake with 0.05 mg of ethinyl estradiol. In order to prevent the development of bleeding appoint the administration of tablets at a dose of 10 mg in the period from 11 to 25 days of menstruation. The intake is combined with 0.05 mg of ethinylestradiol (1 time per day).
If necessary, hormone replacement therapy is used in combination with estrogens. Continuous treatment involves taking 10 mg of the drug for 14 days during each monthly cycle. If necessary, the dose may be increased to 20 mg per day.

How to take Duphaston with endometrial hyperplasia depends on what other drugs the doctor is prescribed for treatment. Typically, the treatment of endometrial hyperplasia involves taking the drug at a dose of 10 mg from the 16th to the 25th day of the cycle.
How to take Duphaston with an ovarian cyst, also depends on the appointment of a specialist. With the ovarian cyst, treatment should last at least 3 months.
Treatment of the follicular ovarian cyst provides the appointment of 10 mg of the drug 2 times a day. A similar dose per day is prescribed if treatment is performed for ovarian dysfunction, and if multifollicular ovaries are diagnosed.
If a woman misses Duphaston's pill, then an extra dose should not be taken. You need to continue taking the next pill. For convenience, we can consider how many tablets in the package Duphaston is left, and monitor the regularity of the reception.
With any diagnosis, Duphaston should not start drinking without prescribing a doctor.

Overdose

There is no information about an overdose of the drug. If a high dose has been taken by accident, and the patient is experiencing discomfort or nausea from the pills, the stomach should be washed and symptomatic therapy should be performed.

Interaction

With the simultaneous administration of inducers of microsomal liver enzymes (Rifampicin, Phenobarbital), it is possible to accelerate the metabolism of dydrogesterone and reduce the effect.
There is no evidence of incompatibility with other drugs.
Dufaston and Proginova can be administered concurrently, most often when planning pregnancy. Proginova is an estrogen preparation.
Duphaston and Klostilbegit are prescribed in a complex for the treatment of infertility. Clostilbegit is a non-steroidal antiestrogen that stimulates ovulation.
Borovoy uterus and Duphaston - the compatibility of these drugs is controversial. There is evidence that phytopreparation of the hog uterus in conjunction with Duphaston can provoke bleeding.

Storage conditions

The manufacturer provides that the tablets should be stored at a temperature of no more than 30 ° C, in a dry place.

Shelf life

5 years. After this period, should not be used.

special instructions

If Duphaston is used in combination with estrogen, care should be taken in patients suffering from vascular, heart, kidney, diabetes, epilepsy, migraine. Also carefully prescribed for liver disease.
If a woman is prescribed a drug for hormone replacement therapy, a number of studies should be carried out before starting, and later, mammography should be performed regularly. It is important to take into account all contraindications. The doctor should clearly study the patient's anamnesis. During HRT, it is necessary to monitor the tolerability of such treatment at certain intervals. There is a possibility of breakthrough bleeding in the first months of therapy. If such bleeding occurs also after the course of treatment, a woman needs an endometrial biopsy to exclude malignant processes.
Do not take Duphaston to those who suffer from deficiency of lactase, galactose or malabsorption syndrome.
Does not affect the ability to drive a car or work with precise mechanisms.
If regular discharge appears when taking tablets, you should tell your doctor about it.
Since Duphaston is a synthetic progesterone, it can replace the natural hormone progesterone, for which Duphaston is prescribed to pregnant women, as well as to women during pregnancy planning. How to drink Dufaston to become pregnant, determines the attending physician. On the question, whether ovulation inhibits this drug, experts unequivocally answer negatively. How this medicine affects ovulation depends on the frequency and duration of its administration.
Often, women are interested in whether the drug can cause a delay in menstruation, or how to drink to call menstruation. It should be understood that the regulation of monthly provides production in the body of estrogens and progesterone. Often a woman notes that she has not started her period, if her body lacks progesterone. If the ovaries produce for some reason not enough progesterone, Duphaston's course is prescribed. If you do not come monthly after taking Duphaston, you should do a pregnancy test. Provided that there is no monthly after the withdrawal of the drug, and the woman is not pregnant, she should always consult a doctor. The reason for the meager monthly after the drug may be a lack of estrogen, late ovulation, changes in the uterus.
It should be borne in mind that, while practicing Duphaston to call monthly "for convenience", without the doctor's prior appointment, a woman even causes a period, but at the same time risks to disrupt the functions of the hormonal system. As a consequence, after uncontrolled treatment, a woman sometimes complains that she has a copious monthly period after taking the pills or a long period of time.
Therefore, the answer to the question, whether it is possible to take without the appointment of a doctor Dufaston, is unambiguous: this should not be done.
Another question that interests women: are they recovering from Duphaston? Namely, do they get fat from him with prolonged admission? Since the active substance of the drug is a synthetic progesterone, the question of whether it is getting fat from it is answered in the negative.

For children

Children are not appointed. The drug can be administered to adolescent girls for violations of the monthly cycle. How to properly take when a cycle in girls these tablets, individually determined by the doctor. After consultation, he determines whether it is possible to drink with a monthly remedy, and whether it is expedient to do so.

Duphaston AND ALCOHOL

Since the drug often has to be drunk for an extended period, many women are interested in whether it is possible to drink alcohol during treatment. In the instructions to the drug there is no information about this. At the same time, many reviews indicate that alcohol can be consumed in small quantities. Nevertheless, doctors warn that the combination of alcohol and hormonal drugs can adversely affect the hormonal background, on the functions of the liver and provoke other negative phenomena. In addition, the effectiveness of the drug when combined with alcohol is significantly reduced. Those who become pregnant on Dufaston, alcohol is categorically contraindicated.

Duphaston during pregnancy and lactation

The instruction indicates that the drug can be drunk during pregnancy. Taking pills during pregnancy is possible in the early stages in order to prevent miscarriage. Therefore, Duphaston in pregnancy at an early age is prescribed to women who previously suffered from a habitual abortion, or who had a frozen pregnancy. But, as a rule, the doctor recommends such patients Duphaston's reception during pregnancy planning. Whether it is possible to drink the drug, how much to take and how to take Dufaston while planning a pregnancy, the doctor determines after the woman tests for progesterone. During the discussion of the drug Duphaston during pregnancy, doctors' testimonies indicate that this drug should be administered only after a thorough and thorough examination of the patient.
As a rule, during the planning of pregnancy, the drug is taken within 3-6 months. You need to drink the medication from 11 to 25 days. But this scheme is relevant only for women who have a monthly cycle of 28 days. How much to drink medicines at other duration of a cycle, the doctor will prompt.
It is also important to know how to cancel this medicine during pregnancy. Provided that the pregnancy occurred against the background of taking pills, Dufaston should be taken further. During the gestation period, the dosage is 20 mg per day (for two doses). It should also be considered how to abolish during pregnancy Dufaston correctly. Necessarily need to consult a doctor, how to reduce the dose and up to what a week they drink tablets. The scheme for abolition during pregnancy provides for taking the drug before the 20th week of pregnancy, but sometimes the time to take the medicine depends on the individual state of health of the expectant mother. Some women are recommended to cancel as early as week 16. But in any case, in detail to recommend how to cancel during pregnancy Dufaston, should only a gynecologist. Do not be guided by the advice that other women write on forums or in reviews about the facility. After taking and after discontinuing the drug, it is important to regularly monitor the condition of a woman. In pregnancy, in some cases, Duphaston and Proginova are appointed simultaneously.
Often pregnant women are interested in how the whole Duphaston's body affects, in particular, whether it is getting better from it. It should be noted that weight gain during pregnancy is a physiological process, it is not associated with taking tablets.

Reviews of Duphaston

Women who take hormonal pills Duphaston, reviews leave in most cases positive. Often the network notes that the drug helps to become pregnant, that is, it increases the likelihood of conception.
Reviews of Duphaston when planning pregnancy indicate that if you follow the intake scheme and under the supervision of doctors, you can get the desired result. However, whether it helps to become pregnant with infertility depends on whether the diagnosis was correctly established. Women also write on the forums that the drug can significantly alleviate symptoms with menopause.
There are also many positive reviews about the use of the drug in endometriosis, cyst, polycystic ovary, ovarian cyst, etc. The drug is often prescribed in a complex (for example, with LS Proginova, etc.).
Women who have practiced the treatment of endometriosis and other diseases with Duphaston sometimes write about side effects. Most often when taking tablets, patients have such side effects: nausea, diarrhea, abdominal pain, general weakness, and excess weight.
Many patients, taking the pill during pregnancy, managed to give birth to healthy babies. Reviews of Duphastone in violation of the cycle in most cases indicate that after a course of taking pills, the monthly cycle stabilized. Also often there are positive responses about Duphaston at a delay of monthly. Experts in the network also often discuss Duphaston. Reviews of doctors with myome and other diseases of the gynecological profile indicate that specialists consider this drug effective.
Among other things, the network often discuss whether Duphaston is hormonal or not. Patients ask questions about whether hormones are hormones or not, and specialists. Many reviews from those who have helped to get pregnant taking pills. At the forums, women discuss whether it is possible to become pregnant when taking the drug, whether it affects ovulation, in particular, suppresses ovulation or not. Often there are descriptions of individual situations, for example: "I drink the drug, but there are no monthly ones," "I drank 10 days, and there are no monthly ones."
Regarding the drug intake in women, there are many questions that they ask the network specialists. Often asked about whether it is possible to take during menstruation Duphaston, whether it affects the level of hCG its reception, whether it is possible to get better from it.