Lomexin vaginal caps 600mg #2

Lomexin vaginal capsules instruction for use

You can buy Lomexin vaginal capsules on this page

Release form, composition and packaging

Vaginal capsules are soft, oval, yellowish, shiny; the contents of the capsules - an oily suspension of white color, thick, homogeneous.
1 caps
fenticonazole nitrate 600 mg
Excipients: soy lecithin, liquid paraffin, petrolatum.
The composition of the capsule shell: glycerol, gelatin, propyl parahydroxybenzoate sodium, titanium dioxide, ethyl parahydroxybenzoate sodium.

pharmachologic effect

Antifungal broad-spectrum drug for local use in gynecology. Fenticonazole is a synthetic derivative of imidazole (its racemic mixture in the form of the nitric acid salt of fenticonazole). It has a local fungicidal and fungistatic effect. It also has antibacterial and anti-inflammatory effects. The mechanism of action is to inhibit the synthesis of ergosterol, which regulates the permeability of the cell membrane of fungi.
Active against yeast fungi Candida spp. (including Candida albicans) and gram-positive bacteria (Staphylococcus aureus, Streptococcus spp.), as well as against Trichomonas vaginalis.
Unlike other known azole compounds (in particular, econazole, miconazole and ketoconazole), fenticonazole inhibits the biosynthesis of Candida spp. Proteases. at concentrations below the IPC - from 0.25 to 16 μg / ml. This action does not depend on the amount of antimycotic activity and is due to the inhibition of one of the stages of the formation of proteolytic enzymes by yeast-like fungi.

Pharmacokinetics

Fenticonazole is practically not subjected to systemic absorption, with prolonged vaginal use, its concentration in the blood is not determined. The degree of absorption into the mucous membrane is extremely small.

Indications

- vulvovaginal candidiasis;
- vaginal trichomoniasis.

Contraindications

- pregnancy;
- lactation period;
- childhood;
- Hypersensitivity to Lomexin capsules.
The drug should not be prescribed during menstruation.

Dosage

1 capsule (600 mg or 1000 mg) is inserted deep into the vagina in the supine position before bedtime once. If necessary, re-use after 3 days.
When treating infections caused by Trichomonas vaginalis, it is possible to re-use the capsule (600 mg or 1000 mg) after 24 hours.
With a lack of effectiveness, it is possible to re-rate after 10 days.

Side effects

Allergic reactions: urticaria, rash, erythema.
Local reactions: burning, itching, irritation at the site of application.
Lomexin capsules are generally well tolerated, side effects are transient in nature and do not require discontinuation of the drug.

Overdose

Due to the low degree of absorption into the systemic circulation, overdose is unlikely.

Drug interaction

Drug interaction of the drug Lomexin capsules with other drugs was not detected.

special instructions

With prolonged use of Lomexin capsules may develop sensitization. In this case, it is necessary to stop the treatment, and the patient should contact the doctor in charge.
In the absence of effect within 3 weeks of therapy, treatment should be discontinued and the diagnosis clarified.
The course of treatment is advisable to start after menstruation.
In order to avoid reinfection, it is recommended to simultaneously treat the partner with Lomexin cream, which is applied to the glans penis and foreskin.
Influence on ability to drive motor transport and control mechanisms
There are no data on the negative impact of the drug on the ability to drive a car and other vehicles.

Pregnancy and lactation

Currently, data on the efficacy and safety of Lomexin capsules during pregnancy and lactation (breastfeeding) is not enough, so the appointment of the drug during these periods is not recommended.

Use in childhood

Contraindicated in children.

Pharmacy sales terms

You don't need a prescription to buy Lomexin capsules.

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature not higher than 30 ° C. Shelf life - 3 years.