Oxytocin 5ME 1ml #5

Oxytocin instruction for use

You can buy Oxytocin on this page

Composition

In 1 ml of oxytocin solution 5 IU.
Chlorobutanol, a solution of acetic acid, water, - as auxiliary substances.

Form of issue

Solution for injection in ampoules of 5 IU in 1 ml.

pharmachologic effect

Stimulating generic activity.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

What is Oxytocin? Wikipedia gives this definition: oxytocin is the hormone of the hypothalamus. Here, the hormone is produced and along the axons of the neurons of the hypothalamic-hypophyseal tract enters the posterior lobe of the pituitary gland, which serves as a reservoir.
The hormone oxytocin is of a protein nature. It has the ability to stimulate contractions of the uterus musculature at the end of pregnancy and the entire period of labor up to delivery. In general, it regulates behavioral reactions associated with pregnancy and childbirth.
At present, it is synthesized. Synthetic unlike natural does not contain other hormones, so it has a more selective effect on the myometrium. Since the drug is free of proteins, it can be used intravenously, without fear of anaphylactic action. The mechanism of action is associated with the effect on the cells of the myometrium: the permeability of membranes for potassium ions increases and the excitability increases. The frequency and duration of uterine contractions increases. Stimulates the secretion of milk, enhancing the production of the hormone prolactin (lactogenic hormone) and enhancing the reduction of lactating breast cells. Has an indistinct antidiuretic effect. Virtually does not affect blood pressure.

Pharmacokinetics

After IV introduction, the effect manifests itself immediately and gradually decreases (up to 1 hour), with the / m introduction the effect is manifested in 3-5 minutes and lasts from 30 minutes to 3 hours. The effect is individual, which is explained by the density of oxytocin receptors in the muscular cells of the uterus. Quickly absorbed into the bloodstream through the nasal mucosa. The connection with proteins is about 30%. T ½ 1- 6 minutes, this period is shortened in late pregnancy and during breastfeeding. Metabolised in the liver and kidneys. It is excreted by the kidneys.

Indications for use

    stimulation and stimulation of labor;
    rodovozbuzhdenie for medical reasons (Rh-conflict, gestosis, a pregnant pregnancy, intrauterine fetal death, premature withdrawal of water);
    prevention of bleeding after abortion or after scraping;
    incomplete abortion;
    acceleration of uterine contraction in the early postpartum period;
    increased uterine contraction in cesarean section (injection is performed after removal of the afterbirth);
    premenstrual syndrome, which is accompanied by edema and increased body weight;
    hypolactation after childbirth.
    

Contraindications

    hypersensitivity;
    high blood pressure;
    severe cardiovascular disorders;
    threatening rupture of the uterus;
    mismatch in the size of the fetus and pelvis of the mother;
    presence of postoperative scars on the uterus;
    transverse and oblique position of the fetus;
    narrow pelvis;
    suspicion of placental abruption before time;
    placenta previa;
    intrauterine fetal hypoxia;
    hypertensive contractions of the uterus;
    severe preeclampsia toxemia.

Side effects

    nausea, vomiting;
    allergic reactions;
    arrhythmia and bradycardia;
    increased blood pressure;
    retention of urine;
    excessive labor activity, which leads to premature detachment of the placenta and the risk of rupture of the uterus;
    subarachnoid hemorrhage;
    reduction of fibrinogen in the fetus;
    neonatal jaundice.

Oxytocin injections, instructions for use (Method and dosage)

The drug in the form of injections is administered intravenously or intramuscularly.

Instructions for use Oxytocin

Oxytocin at delivery for the purpose of excitation of labor is used intramuscularly 0.5-2.0 IU. Injections can be repeated every 30-60 minutes. If there is a need for drip administration, then 1 ml (5 IU) is diluted in 500 ml of 5% glucose solution. First injected at a speed of 5-8 drops per minute, then, depending on the labor, increase the speed of a maximum of 40 drops per minute.
In order to prevent bleeding after the birth in the first day, intramuscularly administered 5-8 IU three times a day for 3 days. During the operation of cesarean section, injections are made in the uterine wall 3-5 ME (after the extraction of the fetus). Overdose of oxytocin in childbirth can cause a child to have jaundice of newborns, caused by drug hemolysis.

Instructions for use for animals

There is a veterinary drug, which in 1 ml contains 5 or 10 units of oxytocin. In veterinary medicine it is used for prolonged childbirth in animals, delayed afterbirth, postpartum uterine bleeding, for the treatment of endometritis, agalactia (lack of milk) and mastitis.
It is used once: dogs are injected - 5-10 units, depending on weight, cats - 2-3 ED. For a quick effect, intravenous glucose is administered, in which case the dose is reduced by 30%. It is possible to re-introduce, but the reaction to the drug decreases with each administration.

Oxytocin for abortion

Oxytocin has abortive action - causes contractions and provokes miscarriage. Its use for this purpose is permissible on terms up to 4-5 weeks, but more often gynecologists use Mifepristone and Misoprostol.
Oxytocin is also used in pregnancy from 14 weeks during the performance of induced abortion due to medical conditions (frozen pregnancy, malformations in the child). The drug is injected into the cervical region after taking Mifepristone and Misoprostol, if the miscarriage was not complete or with incomplete spontaneous miscarriage, but intravenous infusions are more often performed. However, in the second trimester the drug often causes hypertension of the uterus. Even with adequate use, hypertensive contractions of the uterus can occur with increased sensitivity to oxytocin.
Medical abortion is carried out only in a medical institution under the supervision of a doctor, control of the contractile function of the uterus and the general condition of the woman. The doctor must make sure that the fetal egg is out of the uterine cavity. In addition, the procedure is dangerous because of bleeding.
Dosage Oxytocin for abortion is determined by the doctor, since the frequency of uterine contractions and their duration depends on it. Women who have fibroids, anomalies of the development of the uterus, scars on the neck, interruption of pregnancy Oxytocin is contraindicated.

Overdose

It manifests as symptoms of hyperstimulation of the uterus, which leads to tetanic contractions, its rupture, and bleeding. The fetus has bradycardia, hypoxia and asphyxia, birth trauma.
When symptoms of an overdose occur, the drug is urgently discontinued, fluid administration is reduced, diuretics prescribed, hypertensive saline solutions, barbiturates.

Interaction

The drug potentiates the vasoconstrictive effect of sympathomimetics. Use with caution with Ftorotan and Cyclopropane, as the risk of arterial hypotension increases.

Inhalation drugs for anesthesia weaken its effect on the uterus. Prostaglandins enhance its stimulating effect. Application with MAO inhibitors appears the risk of hypertension.

Storage conditions

At a temperature of 4-15 ° C.
Shelf life - 2 years.

Reviews about Oxytocin

Oxytocin - what is it? Oxytocin is a "love hormone", it's not for nothing that they call it, because an increased level is determined by women and men during the period of falling in love. It helps to strengthen emotional and sexual affection and tenderness between representatives of different sexes. This has been repeatedly proven in studies: injection of a nasal spray leads to increased sexual desire, improved sexual life. In addition, it is called the "elixir of trust". Individuals with an elevated level of this hormone tend to trust other people, become more kind and open.

A particularly high level of hormone is produced in women at the time of the birth of the child - this condition can be called "explosion of oxytocin." Thus, oxytocin is produced during feeding, as the sucking reflex contributes to its formation. At the same time, uterine contraction is accelerated and the risk of postpartum bleeding decreases. The hormone helps to strengthen the connection between the mother and the baby and causes the maternal instinct, increased care and tenderness towards the child. A slightly smaller "explosion" of oxytocin is observed during orgasm.

Interestingly, a nasal spray containing oxytocin reduces appetite and craving for fatty foods. The researchers found that after using the spray, volunteers consumed less food. At present, studies of the effect of oxytocin on the brain activity of autistic children are continuing. As the activation of those zones of the brain, which are oppressed in these children, is found.

In another study, a similar effect of alcohol and oxytocin on human behavior was noted. acting on different receptors, they cause similar changes in GABA in the limbic structures that are responsible for the perception of stress and anxiety. This hormone reduces feelings of anxiety and fear, and on the other hand - provokes ill-considered actions, causes aggressive and risky behavior.

What foods contain oxytocin? Can I refill it by eating? The hormone oxytocin in food is not contained, so it does not enter the body from outside. It is established only that the use of dates promotes its synthesis during pregnancy and childbirth. Reception dates, which contains more than 10 elements, a large amount of fructose, it is recommended a few days before delivery. Stimulate the release of this hormone stroking and embracing, a pleasant partner's voice, massage of the feet, earlobes.

For many years, the drug is the most effective for stimulating mild labor, treating uterine bleeding, with medical abortion, and therefore often used in obstetric and gynecological practice. Analyzing the reviews, we can conclude that the drug is really prescribed for many people during and after delivery. Some women experienced a sharp increase in contractions and, accordingly, pain, and some "did not respond" to the administration of the drug - it depends on individual sensitivity.

Now that we have analyzed what it is, we learned about the indications, contraindications and side effects of it, as a preprat, it must be said that it is not safe to experiment with the home and try to disrupt the early pregnancy with oxytocin. In fact - this is a criminal abortion, and the consequences of using the drug for this purpose are unpredictable: loss of genital function, bleeding of varying degrees and even fatal outcome. In addition, it is impossible to buy this drug in a pharmacy, because you need a prescription in Latin, written by a doctor. For the sake of preserving one's health, use the legal methods of abortion!

This drug is used for animals, and in this case you need to know what dosages are used in veterinary medicine. This is often asked in the forums. There are general rules for the use of the drug. It is used only after the birth of the first puppy or kitten, when the cervix is ​​open, otherwise it can cause a rupture of the uterus. If it does not work, do not repeat the dose. Contraindicated to accelerate childbirth, making injections after the birth of each puppy. It is not recommended to do injections if the dog is unsuccessfully taut, and you suspect that the puppy is "stuck". Intramuscularly, 0,3-0,4 ml is injected to the cat at delivery, if there is a weakness of labor and prolonged labor, there are doubts that not all kittens were born. If the product was not used during childbirth, it is administered after the delivery at a dose of 0.3 ml. Dosage for dogs is 1-2 ml, depending on the weight.