Primafungin supp 100mg #3

Primafungin user manual

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Composition

In 1 suppository of natamycin, 100 mg. Spirits cetyl, sorbitan, polysorbate, sodium bicarbonate, adipic acid, semi-synthetic glycerides, as auxiliary substances.

Form of issue

Vaginal suppositories №3.

pharmachologic effect

Antifungal.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The active substance refers to polyene antibiotics with an antifungal fungicidal action. Natamycin binds the fatty acids of the cell membranes of microorganisms, violates their function and causes death. To it are sensitive yeast-like fungi Candida albicans, Microsporum, Trichophyton, Epidermophyton, Aspergillus, Fusarium, Penicillium. Active with respect to the simplest (Trichomonas). Suppositories are melted, forming a bulk foamy mass, which evenly distributes the active substance over the vaginal mucosa. Resistance to natamycin is not found. Primafungin during pregnancy is allowed at all times, and can also be used during lactation. With the use of this drug, the vaginal biocenosis is preserved.

Pharmacokinetics

Almost not absorbed from the surface of the mucosa of the vagina and does not have a systemic effect.

Indications for use

    fungal diseases of the vagina and vulva;
    prevention of fungal lesions in the treatment of glucocorticoids, cytostatics, or antibiotics.

Contraindications

Hypersensitivity.

Side effects

    burning sensation in the vagina;
    irritation of the mucosa.

Primafungin, instructions for use (Method and dosage)

Suppositories Primafungin appoint for 4-6 days. Enter 1 candle deep into the vagina, lying on your back, every day for the night. Suppositories can not be cut into pieces, as this disrupts the uniform distribution of the active substance.
In the period of menstruation treatment must be interrupted. During the period of treatment, barrier contraceptives should be used.
It is recommended to have an examination of the sexual partner and, if necessary, to conduct a course of treatment.

Overdose

Cases of overdose are not registered.

Interaction

The interaction was not studied.

Storage conditions

Storage temperature 15-20 ° C.
Shelf life - 2 years.

Reviews of Primafungin

Primafungin is an effective remedy for topical treatment of candidal vulvovaginitis, including in pregnant women. Studies have shown efficacy, which was confirmed by positive dynamics and laboratory results.
However, the responses of the patients are different and many frighten abundant secretions together with the outgoing components of the candle. Many believe that treatment does not help. But on the sixth or seventh day there was an improvement: the burning and itching disappeared, the discharge from the vagina stopped. In primary vulvovaginal candidiasis, the drug was administered as monotherapy within 6 days, and with a recurrent one, probiotics were administered in parallel and the treatment was 9 days.
    "... The drug is good, it suits me, in the early days the symptoms persist, and then everything goes on for a long time."
    "... I use them for the third time for pregnancy. It calms down for 2-3 months. "
    "... In pregnancy, the safest drug. After the first candle is much easier, and after the end of the course - the smear is perfect. "
    "... Primafungin used - he did not help me, the itching sensation still did not pass."
    "... The most effective ones were rid of thrush in a week."
    "... I prefer the cheaper Primafungin."