Biseptol tabs 480mg #28

Biseptol instruction

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Composition

The preparation consists of a combined active substance Co-Trimoxazole, which consists in turn of substances sulfamethoxazole (200 mg for suspension and 100 mg (400 mg) for tablets) and trimethoprim (40 mg for suspension and 20 mg (80 mg) for tablets).

Additional funds

For suspension: purified water, macrogol, sodium carmelose, propylene glycol, propylparahydroxybenzoate, aluminum-magnesium silicate, sodium saccharin, citric acid monohydrate, maltitol, sodium hydrophosphate dodecahydrate, methyl parahydroxybenzoate.
For tablets: propylene glycol, potato starch, methyl parahydroxybenzoate, talc, propylparahydroxybenzoate, magnesium stearate, polyvinyl alcohol.

Form release

Available in a tablet form of 120 (often called "Baby Biseptol") and 480 mg of active ingredients, in the form of a suspension (syrup).

Pharmacological action

Bactericidal, antibacterial.
Is Biseptol an antibiotic or not? This remedy is not an antibiotic.

Pharmacodynamics and pharmacokinetics

Combined antimicrobial drug. The main active ingredient is Co-Trimoxazole (trimethoprim+sulfamethoxazole). What is it used for? Biseptol has a double blocking effect on the metabolism of bacteria. Trimethoprim has an inhibitory effect on the enzyme involved in the metabolism of folic acid, and turns dihydrofolate tetrahydrofolate. Sulfamethoxazole has a bacteriostatic effect. The complex components of the drug Biseptol inhibit biosynthesis of purines and nucleic acids, without which it is impossible to reproduce and bacterial growth.
Active ingredients are actively absorbed from the digestive tract. Excreted mainly through the kidneys.

Indications for use of Biseptol

What are these pills and suspension for?

In General, the drug is prescribed for infectious lesions of the urinary tract: pyelitis, urethritis, prostatitis, pyelonephritis, gonorrhoea, epididymitis, venereal lymphogranuloma, soft shankr, inguinal granuloma. Consider Biseptol from which helps parts of the body.
Indications for use of Biseptol in infections of the gastrointestinal tract: parathyroid, cholera, typhoid, cholangitis, dysentery, gastroenteritis (E. coli), cholangitis, Salmonella.
Respiratory tract infections: major pneumonia, bronchiectasis, bronchitis (acute and chronic), Pneumocystis pneumonia, bronchopneumonia.
Infections of ENT organs: angina, sinusitis, otitis media, scarlet fever, laryngitis.
Infections of soft tissues, skin: furunculus, acne, wound infections, pyoderma. In complex therapy it is used for treatment of toxoplasmosis, malaria, South American blastomycosis, acute brucellosis.

Contraindications

Aplastic anemia, leukopenia, pregnancy, agranulocytosis, B12-deficiency anemia, severe disorders in the renal/hepatic systems, hyperbilirubinemia in children. With caution, Biseptol is prescribed for bronchial asthma, a lack of folic acid, thyroid diseases.

Side effect

Nervous system: dizziness, headaches, rarely depression, aseptic meningitis, tremor, apathy, peripheral neuritis.
Respiratory system: pulmonary infiltrates, bronchospasm.
Digestive system: dyspepsia, cholestasis, diarrhea, vomiting , decreased appetite, glossitis, epigastric pain, gastritis, increased liver transaminases, stomatitis, pseudomembranous enterocolitis, hepatonecrosis, hepatitis.
Hematopoietic organs: megaloblastic anemia, agranulocytosis, neutropenia, leukopenia, thrombocytopenia.
Side effects of the urinary system: crystalluria, interstitial nephritis, polyuria, toxic nephropathy with anuria, oliguria, increased urea, hematuria, impaired renal function.
Musculoskeletal system: myalgia, arthralgia. thrombophlebitis, hypoglycemia, Allergy.

Instructions for use Biseptol (Method and dosage)

The dose of the drug in each case, the doctor appoints.

Biseptol tablets, instructions for use

Adults 960 mg once, or 480 mg for 2 admission. Severe infections: three times on 480 mg. a Course of 1-2 weeks.
In acute brucellosis, the treatment course is 3-4 weeks, paratyphoid and typhoid fever – up to 3 months.
Chronic infections: twice tablets of 480 mg.

Instructions for use for children

Children Biseptol prescribed twice a day, a dose of 120 to 480 mg.
At the age of 3-5 years: 2 times 120 mg in 24 hours.

Suspension Biseptol, instructions for use

Syrup is used similarly to the dosage of tablets.

Overdose

Intestinal colic, dyspeptic disorders, headaches, dizziness, drowsiness, vomiting, confusion, fever, depression, hematuria, fainting, visual disturbances, leukopenia, fever, crystalluria. With prolonged overdose, jaundice, megaloblastic anemia, thrombocytopenia, leukopenia are noted. It is necessary to introduce trimethoprim, calcium folinate intramuscularly at a dose of 5-15 mg/day. If necessary, appoint hemodialysis. There is no specific antidote.

Interaction

Biseptol enhances the effect of hypoglycemic drugs, indirect anticoagulants, methotrexate. The drug reduces the effectiveness and reliability of oral contraception. The risk of developing megaloblastic anemia is increased when administered simultaneously with pyrimethamine (25 mg weekly). Thiazides can cause thrombocytopenia. The effectiveness of Biseptol reduce procainamide, procaine, and benzocaine. The drug leads to the development of cross-Allergy with concomitant administration of oral hypoglycemic drugs. The lack of folic acid is increased in the appointment of barbiturates, phenytoin, PASC. Crystalluria develops in the admission of hexamethylenetetramine, ascorbic acid.

Terms of sale

To buy Biseptol you don't need a prescription.

Storage conditions

Out of the reach of children, at a temperature not exceeding 25 degrees Celsius.
Shelf life - 3 years.

Special instruction

Requires regular monitoring of the concentration of sulfamethoxazole in the blood. If the index is greater than 150 µg/ml, the treatment is stopped until the value of 120 µg/ml and below. If the course of treatment is designed for a month or more, it requires regular blood monitoring. In appointing folic acid hematological changes are reversible. In AIDS patients, side effects are more common and pronounced. Biseptol is not recommended for pharyngitis and tonsillitis caused by beta-hemolytic Streptococcus gr. Ah.
There is no description of the medicine in Wikipedia.

Biseptol for children

It is noted that the drug can be used from 3 months of life, naturally will vary and doses. However, it should be done with caution and only on the instructions of the doctor. In some countries of the world Biseptol for children is allowed to use only 12 years.
Usually can appoint a suspension from 3 months, tablets - from 2 years.

Biseptol instruction for children

At the age of 3 to 6 months appoint 2,5 ml syrup 2 times a day. The interval between doses should be not less than 12 hours. From six months to 3 years take up to 5 ml of Biseptol suspension for children twice a day.
From 3 to 6 years, the dosage is made equal to 5-10 ml twice, 6-12 years — 10 ml 2 times a day. With 12 years accept on 20 ml every 12 hours.

How to take pills to children?

Age 2-5 years: 2 times 120 mg in 24 hours. From 6 to 12 years use 480 mg every 12 hours.
The course of treatment is 5-7 days. When using LS for children should use a large amount of water.

Work with alcohol

The reaction of a combination with alcohol is impossible to predict. Consumption of these substances together is undesirable.

Reviews about Biseptol

The tool is very effective, especially in diseases of the respiratory system. It has an excellent antibacterial effect. Of the disadvantages should be noted sometimes arising side effects. It should not be used without the advice of a physician.

Biseptol children reviews

It is considered very effective for fighting germs. Negative feedback in the treatment of Biseptol syrup for children is mostly not found.

Reviews of Biseptol in cystitis

The drug is effective against cystitis, but do not forget about the side effects.

Under angina

It is prescribed when it is impossible to take antibiotics. According to research, microorganisms that cause angina began to lose sensitivity to this drug.