Champix tabs 1mg #28

Champix instruction for use

You can buy Champix online

Composition

The composition of Champix includes the active substance varenicline tartrate, as well as additional ingredients - microcrystalline cellulose, croscarmellose sodium, colloidal silicon dioxide, calcium hydrophosphate, magnesium stearate.

Form of issue

Produced in the form of tablets.
Tablets that contain 850 μg of varenicline tartrate are capsular-shaped, white or almost white in color. They are biconvex, with a film sheath, on the one hand - engraving "Pfizer", on the other - "CHX 0.5".
Tablets that contain 1.71 mg of varenicline tartrate have a capsular form, a light blue color. They are biconvex, with a film sheath, on the one hand - engraving "Pfizer", on the other - "CHX 1.0".
Packed in blisters for 11, 14 or 28 pieces, as well as in cans of polyethylene for 56 pieces.

pharmachologic effect

Tablets are used to treat dependence on nicotine. The active substance varenicline, when ingested, binds to α4β2 n-cholinergic receptors, in relation to which it is partially a nicotine agonist. Thus, simultaneous agonist activity (its degree is less than in nicotine) and antagonism in the presence of nicotine are noted.
Consequently, varenicline blocks the ability of nicotine to stimulate α4β2 n-cholinergic receptors and inhibits its activity with respect to the mesolimbic dopamine system. This mechanism is the basis for the formation of dependence on nicotine, that is, the pleasure derived from smoking.
Tablets from smoking Champix reduce craving for tobacco smoking, and significantly alleviate the symptoms of withdrawal syndrome. At the same time, the person taking this drug, gradually notes a decrease in the sense of pleasure from smoking.

Pharmacokinetics and pharmacodynamics

The highest level of concentration of the active substance in the blood plasma is observed about 3-4 hours after the oral administration of Champix. After ingestion, the drug is almost completely absorbed, there is a high level of its systemic bioavailability, which is not associated with the period of its reception throughout the day, with use in relation to food intake.
After the drug was taken once (a dose of 0.1 mg to 3 mg) or after repeated administration or repeated administration of Champix in a similar dose, the linear character of the pharmacokinetics of varenicline was noted.
The active substance is distributed in the body tissues, penetrates the blood-brain barrier and enters the brain. There is a low degree of binding to blood plasma proteins - less than 20%.
About 92% in unchanged form is excreted from the body through the kidneys, less than 10% is excreted as metabolites. The half-life of varenicline is 24 hours.
There is no dependence of the pharmacokinetics of varenicline on sex, age, race, and also whether the patient smokes, whether he takes other medicines.

Indications for use

Champix is ​​prescribed for nicotine dependence in adults.

Contraindications

You can not take this remedy in such cases:
    high sensitivity to the components of Champix;
    terminal stage of renal failure;
    patient's age under 18;
    pregnancy and the period of feeding.

Side effects

If during the treatment of Champix the patient stops smoking, this process can be accompanied by a variety of unpleasant symptoms. In particular, there may be problems with sleep, irritability, bad mood, feelings of displeasure, motor anxiety, increased appetite, weight gain. If you quit smoking, you can exacerbate the previously present mental disorders. Also in the process of treatment, patients had a depressive mood, behavioral disorders, and cases of hypersensitivity. But all the undesirable phenomena, primarily associated with the cessation of smoking, and not with the beginning of therapy with the drug. As a rule, they were observed during the first week of treatment and were either weak or moderately expressed.
In the treatment of Champix in a dose that is recommended, most patients noted a mild or moderate nausea. It was rarely necessary to cancel treatment.
In addition, against the background of Champix therapy, such negative manifestations were noted:
    Often - increased appetite, rarely - decreased appetite, anorexia.
    Often - the manifestation of insomnia, unusual dreams, rarely - panic attacks, violation of thinking, unstable mood.
    Often - drowsiness, headache, dizziness, rarely - violations in coordination processes, tremor, hypertension, dysphoria, motor anxiety, hypoesthesia, decreased sexual desire.
    Often - vomiting, constipation, diarrhea, nausea, dyspepsia, rarely - symptoms of gastritis, gastroesophageal reflux disease, abdominal pain.
    In rare cases, heartbeat, infectious diseases, pupil dilated, pain in the eyeball, myopia, increased lacrimation, coughing, shortness of breath, snoring, stasis in the airways and sinuses, rashes, acne, erythema, joint stiffness, spasms muscles, nocturia, glucosuria, polyuria, chest pain, asthenia, malaise, etc.

Instructions for the use of Champix (Method and dosage)

The instruction for Champix provides for taking the drug inside, while it must be washed down with water. Means can be taken regardless of the time of eating.
According to experts, the results of therapy will be more successful in those patients who seriously intend to abandon the bad habit, and take the medicine according to the scheme that provides instructions for the use of Champix.
The beginning of therapy with the drug should be provided one week before the day when the person decided to give up the bad habit. It is recommended that 1 mg of the agent be taken twice a day, dividing this dose according to the following scheme:
From 1 to 3 days: 0.5 mg once a day; from 4 to 7 days - 0.5 mg 2 times a day; From the 8th day until the end of therapy, 1 mg should be taken twice a day. If side effects occur, the dose of the drug may decrease for some time. How to take drugs in this case, the doctor will tell in detail.
The treatment period lasts 12 weeks. If the patient stopped smoking by the end of the twelfth week, an additional course of therapy with the drug is possible, with a dose of 1 mg every day (two times) for another 12 weeks.
Those people who have not managed to get rid of the habit of smoking during a 12-week treatment, or those who have had a relapse after therapy, can retry the treatment, but only if the cause of the breakdown is established and eliminated.
With severe impairment of kidney function in a patient, the Champix dose is reduced to 1 mg once a day. With disturbed liver function, you do not need to adjust the dose of the drug. Champix in the usual dose is also prescribed for the elderly.

Overdose

The cases of a varenicline overdose have not been documented. If necessary, symptomatic therapy is performed. The excretion of varenicline is carried out through hemodialysis in people with severe impairment of kidney function. But with an overdose, there is no experience of using the drug.

Interaction

Clinically significant interaction of the active substance Champix with other drugs is not determined. It is not necessary to adjust the dosage of the noted drugs or varenicline when they are used simultaneously.
In therapeutic doses, varenicline does not affect the transport of proteins in humans. Therefore, varenicline has no effect on the pharmacokinetics of agents, the clearance of which occurs due to renal secretion.
With simultaneous treatment with cimetidine, AUC varenicline increases by 29% because of a decrease in its renal clearance.
The pharmacokinetics of warfarin with simultaneous administration of varenicline does not change. Changes in the pharmacokinetics of warfarin can in itself occur due to cessation of smoking.
With the simultaneous use of nicotine replacement therapy, in particular patches with nicotine, for 12 days there was a significant decrease in the average SAD. Also, more frequent manifestations of side effects - nausea, vomiting, fatigue.

Terms of sale

You don't need a prescription to buy Champix online.

Storage conditions

Keep the drug away from children, store at a temperature of 15 to 30 ° C.
Shelf life - 2 years.

special instructions

When physiological changes occur in the body against the background of Champix treatment after quitting smoking, the pharmacokinetics or pharmacodynamics of a number of drugs may change. In this case, you may need to adjust the dosage of Teofillin, Insulin, Warfarin and other medications.
With the discontinuation of Champix, approximately 3% of people reported increased irritability, depression, sleep problems, increased cravings for smoking.
Before starting treatment with a drug, a specialist should clearly explain to the patient the possibility of manifesting a variety of neuropsychiatric symptoms. It is important to understand that in the treatment of Champix in humans, behavior can be disturbed, a depressive condition is noted. Before treatment, it is necessary to tell the doctor about all the neuropsychiatric manifestations that were noted in a person earlier.
In connection with the fact, when taking Champix may be drowsiness and dizziness, it is not recommended in the process of therapy to drive vehicles and work with dangerous mechanisms. Before the beginning of such actions it is necessary to clearly understand the reaction of the body to taking the drug.

Children

It is not used for the treatment of children and adolescents under 18 years of age, since there is no data on the safety and efficacy of this drug for adolescents and children.

In pregnancy and lactation

Do not use the product at any time of pregnancy, as well as breastfeeding a child.

Reviews Champix

Those patients who took Champix remedy, reviews on the forums leave different, but mostly positive. Many people, taking these pills from smoking, managed to quickly get rid of this addiction. Under the influence of this means, the desire to smoke disappears gradually and relatively imperceptibly. Sometimes patients noted the appearance of some side effects, in particular, nausea, irritability. Nevertheless, when evaluating the Champix drug, the doctors' reviews are mostly positive, since in most cases, after taking the course of the drug, a pronounced effect is noted. Nevertheless, in the main a positive effect was noted in those cases when a person consciously strove to abandon such a harmful habit as smoking.