Irunin caps 100mg #14

Instruction for Irunin

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Composition

The composition of 1 capsule of the drug Irunin is 100 mg Itraconazole. Additional components: methyl parahydroxybenzoate, sugar nibs, hypromellose, titanium dioxide, and methacrylic acid in the form of a copolymer, sucrose, parahydroxybenzoate, gelatin, quinoline yellow dye.
The composition of 1 vaginal tablet Irunin includes 200 mg of Itraconazole. Additional components: sodium lauryl sulfate, starch, lactose, talc, povidone, magnesium stearate.

Form release

The yellow capsule inside a white spherical pellets.
5 pieces in a box package-2, 3 or 1 pack in a carton.
6 pieces per carton-2, 3 or 1 pack per carton.
7 pieces per box - 2, 3 or 1 pack per carton.
10 pieces per box - 2, 3 or 1 pack per carton.
14 pieces per box - 2, 3 or 1 pack per carton.
15 pieces per box - 2, 3 or 1 pack per carton.
5, 6, 7, 10, 14 or 15 pieces in a glass jar — 1 jar in a carton.
White vaginal ring-shaped tablets.
10 pieces in a box package - 1 pack in a carton.

Pharmacological action

Antifungal effect.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Itraconazole is a triazole derivative that exhibits strong antifungal activity. Zithromaxability inhibits P450 enzymes of the fungal cell that causes suppression of the biosynthesis of ergosterol their walls. It has a broad spectrum of antifungal activity. Acts on Sporothrix schenckii, Paracoccidioides brasiliensis, Blastomyces dermatitidis, Cryptococcus neoformans, Histoplasma capsulatum, Malassezia furfur, Coccidioides immitis, as well as fungi Candida, Aspergillus, Microsporum, Epidermophyton, Trichophyton.

Pharmacokinetics

Therapeutic concentrations in the skin tissues remain for 15-30 days after the end of the monthly course of therapy. The drug is determined by the nails 7 days after the start of therapy and remains in them for another six months after the completion of a 3-month course of treatment.
With the introduction of endovaginal achieves an effective local concentration of the active substance. System suction is minimal.

Indications for use

Indications for use of capsules

mycosis of the skin, eyes, oral mucosa;
onychomycosis, the causative agent of which is dermatophytes or yeast;
vulvovaginal candidiasis;
systemic mycoses (including systemic sporotrichosis, candidiasis, aspergillosis, histoplasmosis, cryptococcosis, blastomycosis, paracoccidioidosis, and other rare systemic mycoses).

Indications for use of vaginal tablets

vulvovaginal candidiasis.

Contraindications

Contraindications to capsules

Joint reception of Dofetilide, Astemizole, Terfenadine, cisapride, Mizolastine, Pimozide, Quinidine, Lovastatin, Simvastatin, Triazolam or midazolam.
Allergy to Itraconazole and other ingredients.

Pregnancy and lactation.

Contraindications to vaginal tablets Irunin

Pregnancy and lactation.
Allergy to Itraconazole and other ingredients.

Side effect

Possible side effects when taking capsules
Reactions from the circulatory system: congestive heart failure, peripheral edema, pulmonary edema.
Reactions from nervous activity: headache, dizziness, peripheral neuropathy.
Reactions from the digestive system: constipation, vomiting, nausea, cholestatic jaundice, hepatitis, abdominal pain, increased liver enzymes.
Other reactions: hypokalemia, hair loss, dysmenorrhea.
Allergic reactions: angioedema, rash, urticaria, itching, Stevens-Johnson syndrome.
Possible side effects when using vaginal tablets
When using vaginal tablets, the following local symptoms may occur: itching, rash on the skin of the genital organs, burning into the vagina. These phenomena do not require the cessation of use of the drug.

Instructions for use Irunin (Method and dosage)

Irunin capsules, instructions for use

The medicine is taken orally. Usually assigned to take 100 mg once a day or 200 mg 2 times a day. The duration of treatment depends on the type of pathogen.

Vaginal tablets (suppositories) Irunin, instructions for use

This dosage form is administered intravaginally, just before bedtime, in a horizontal position of the body with knees bent legs.
The duration of treatment is usually 1-2 weeks. On the recommendation of the doctor, a repeated cycle of treatment is allowed.

Overdose

Signs of overdose capsules comparable to dose-dependent adverse events that occur when taking conventional doses of Irunin. Treatment of overdosage: no specific antidote; within 1 hour after an overdose, you should perform gastric lavage soda solution and assign chelators. Itraconazole is not excreted in hemodialysis.
The use of vaginal tablets in high doses usually does not cause the patient reactions, dangerous to health. In the case of accidental ingestion of tablets, it is necessary to perform gastric lavage and appoint enterosorbents.

Interaction

With the joint use of capsules with drugs that reduce the acidity of the stomach environment, it is possible to weaken the absorption of Itraconazole.
Means that stimulate the activity of liver enzymes can reduce the content of Itraconazole capsules in the blood.
When the joint capsules with the drugs, metabolized by the isoenzyme CYP3A (Terfenadine, Astemizole, Vincristine, Cisapride, Midazolam, oral formulations of Triazolam, Cyclosporine, indirect anticoagulants, Digoxin, Quinidine, blockers of calcium channels), it is possible to strengthen the action of the intensity and duration of their effects.

Terms of sale

To buy Irunin you don't need a prescription.

Storage conditions

Store in a dry, dark place at temperatures up to 26 degrees. Keep away from children.
Shelf life - 2 years.

Special instruction

Special instructions for taking capsules
It is forbidden to use the described medicine in persons with signs of ventricular dysfunction, congestive heart failure, liver disease. In case of acute need in diseases of the kidneys or liver cirrhosis treatment Itraconazole produced by controlling its level in the blood.
With an increased content of liver transaminases in the blood, the drug is used only in cases where the benefits of the drug are higher than the expected risk of liver deterioration.
When using capsules for more than 1 month should be carried out regular monitoring of liver function.
If symptoms of hepatic or heart failure, as well as peripheral neuropathy appear during therapy, the drug should be immediately discontinued.

Special instructions for taking vaginal tablets

During treatment, it is advised to refrain from sexual intercourse.
To prevent reinfection it is necessary to simultaneously carry out therapy in both sexual partners, also it is necessary to follow the rules of hygiene.
In case of Allergy treatment should be stopped immediately. The drug can be removed by washing the vagina with warm water.
If the symptoms of infection after treatment persist, it is necessary to conduct additional microbiological examination to clarify the diagnosis.

With alcohol

Alcohol can increase unwanted effects of hepatotoxic drugs. Therefore, Irunin and alcohol is an undesirable combination.

Pregnancy and lactation

Itraconazole can cause fetal malformations and penetrate into breast milk, so the use of the drug in these periods is contraindicated, except for severe fungal lesions.

Reviews of Irunin

Reviews of Irunin from yeast and reviews of Irunin of nail fungus indicate a high effectiveness of this tool, including in the treatment of other pathologies. However, the ability of the drug to cause severe side effects limits its scope. Reports of ineffectiveness are rare. The drug should be taken only under medical supervision.