Ketosteril tabs #100

Ketosteril user manual

Reed more and buy Ketosteril on this page

Composition

Film-coated tablets, 1 tablet contains active ingredients: isoleucine alpha-keto analog 67 mg, leucine alpha-keto analog 101 mg, phenylalanine alpha-keto analog 68 mg, valine 86 alpha-keto analog, 59 mg, L- lysine monoacetate 105 mg, L-threonine 53 mg, L-tryptophan 23 mg, L-histidine 38 mg, L-tyrosine 30 mg.
Excipients: corn starch, polyvinylpyrrolidone, talc, colloidal silicon dioxide, magnesium stearate, polyethylene glycol 6000, soluble polyvinylpyrrolidone.
Sheath composition: talc, polyethylene glycol 6000, quinoline yellow, copolymer of methyl methacrylate, dimethylaminoethyl methacrylate and butyl methacrylate, triacetin, titanium dioxide.
In total, 1 tablet contains 36 mg of nitrogen and 50 mg of calcium.

Form of issue

Oval convex two-sided tablets in a yellow film sheath are available in a cardboard package of 100 pieces - 5 blisters of 20 pcs. Each. in a sealed aluminum bag placed in a cardboard box.

pharmachologic effect

Ketosteryl (INN - ketoanalogy of amino acids) promotes the restoration of metabolism, disrupted due to inadequate intake of essential amino acids in the body against a violation of the kidneys. Promotes the synthesis of protein in the body, reduces the degree of toxic effects of protein metabolism products on the body, improves the overall condition of patients with chronic renal dysfunction.

Pharmacodynamics and pharmacokinetics

Ketosteril is a medicinal product that contains essential amino acids, without which the body can not function properly. Assign it to a violation of the kidneys on the background of lesions of the kidney tissue and the gradual increase in the content in the blood of toxic products of metabolism, mainly protein.
In the blood of patients, a large amount of residual nitrogen and its components, which exert a toxic effect on the body, is detected. Residual nitrogen is a set of non-protein nitrogen (products of protein metabolism in the blood plasma), consisting of urea, nitrogen of amino acids, uric acid, creatine and creatinine.
Violation of protein metabolism leads to the fact that the body does not receive vital amino acids, while in the blood in large quantities accumulate toxic products of protein metabolism. In order to reduce the toxic load on the body, patients are prescribed a diet with protein restriction, which leads to protein starvation.
Ketosteril supplies the body with essential amino acids (from which the proteins of the human body are built), but the amount of nitrogen that enters while is limited. This is due to the fact that Ketosteril contains ketone analogs of amino acids, which are quickly absorbed by the body and contribute to the utilization of toxic products of protein metabolism.
This mechanism of action contributes to the improvement of protein and mineral metabolism, and hence, the general condition of the patient.
Pharmacokinetics of the drug has not been studied, since all its components are natural constituents of metabolism, and it is impossible to trace their movement in the body.

Indications for use of Ketosteril

The drug is prescribed for the prevention and treatment of violations of protein and mineral metabolism against a background of chronic renal dysfunction in adults and children over 3 years old.
Indication for the use of Ketosteril is a decrease in glomerular filtration to 25 ml / min and below. But the drug can be used in the early stages of the disease, when the glomerular filtration rate is only beginning to decrease (the norm is 100-120 ml / min).

Contraindications for the use of Ketosteril

Ketosteril should not be administered with individual intolerance to its components, elevated calcium levels in the blood, and impaired amino acid metabolism (for example, phenylketonuria, in which amino acid phenylalanine is disrupted), and children under 3 years of age.
With caution, the drug is prescribed in pregnancy, because no clinical trials have been conducted on pregnant women.

Side Effects of Ketosteril

The drug is well tolerated and rarely gives side effects. Nevertheless, they can be in the form of hypercalcemia - a high content of calcium in the blood.
Hypercalcemia manifests itself in the form of weakness, nausea, vomiting, increased blood pressure; the patient drinks a lot of fluids and emits a lot of urine; with chronic hypercalcemia in the kidneys connective tissue grows and stones are formed.

Instructions for use Ketosteril

The medicine is taken orally during meals. Tablets must be swallowed whole, while drinking with a sufficient amount of liquid - this is how they are best absorbed and included in the metabolic processes.
Dosage of the drug is prescribed in accordance with the weight of the patient at the rate of 1 tablet per 5 kg per day. The daily dose is divided into 3-4 doses. The average daily dose for an adult is 12 to 24 tablets.
Instruction on Ketosteril suggests that the treatment course be carried out throughout the period of the decrease in glomerular filtration below 25 ml / min. Simultaneously, a diet with a reduced amount of protein is prescribed. With prolonged intake of Ketosteril, the content of calcium in the blood should be checked periodically.

Interaction of Ketosteril with other medications

Ketosteril should not be used at the same time:
    with calcium preparations - this can lead to hypercalcemia;
    with preparations that form hardly soluble compounds with calcium - antibiotics of the tetracycline group, antibiotics of the quinolone group, drugs containing iron, estramustine and fluorine; between taking these drugs and Ketosteril should be a minimum of two hours.
When the condition improves against the background of Ketosteril administration, in order that the acid-base balance does not break, gradually reduce the dose of aluminum hydroxide, which was prescribed in acidosis (shifting the acid-base balance of the body towards increasing acidity).

Terms of sale

You can buy Ketosteril online without prescription.

Storage conditions

Tablets should be kept in a dry place, while observing a temperature of no higher than 25 ° C. The storage location should not be accessible to children.
Shelf life - 3 years if the above conditions are met.

Reviews of Ketosteril

Ketosteril is a medicinal product used in the complex treatment of patients with impaired renal function. Almost all patients who received it noted a gradual improvement in the general condition, confirmed by laboratory tests.
Negative responses about Ketosteril practically are not present, but some patients marked, that the improvement of a status goes too slowly, that, most likely, has been connected with severity of disease.