Tranexam tabs 250mg #30

Tranexam user manual

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Composition

The composition of the drug includes the active ingredient: tranexamic acid.
Additional components of the drug in tablets: MCC, talc, giprolose, calcium stearate, sodium carboxymethyl starch, silicon colloidal dioxide, hypromellose, macrogol.
Auxiliary substance of the solution for the introduction into the vein: water for injection.

Form of issue

Produced Tranexam in the form of tablets and a solution for injection into the vein. Tablets with an active component content of 250 and 500 mg are packaged in contour cells of 10 pieces, 1, 2, 3, 5 cells per package.
The solution for administration is packaged in ampoules of 50 ml, 5 pieces in contour cells, 1-2 in the package.

pharmachologic effect

Solution and tablets Tranexam have antifibrinolytic, hemostatic, anti-allergic and anti-inflammatory effects.

Pharmacodynamics and pharmacokinetics

The main component of this drug, tranexamic acid, is an antifibrinolytic substance that inhibits the activity of the fibrinolysin or plasminogen, promoting its subsequent conversion into fibrinolysin or plasmin. This manifests a local and systemic haemostatic effect, necessary for bleeding, which causes a high content of fibrinolysis, characteristic for the pathology of platelets and menorrhagia.
Also anti-inflammatory, antiallergic, anti-infectious and antitumor effect is observed, which is provided by suppressing the production of kinins and other active peptides taking part in inflammatory and allergic processes. Tranexamic acid has its own analgesic effect, but it also stimulates the analgesic activity of opiates.
Inside the body, the drug undergoes moderate absorption, slightly binding to plasma proteins. The basic substance is evenly distributed in the tissues, penetrates the placental barrier, enters the breast milk. The drug can also be found in seminal fluid, which reduces fibrinolytic activity without affecting the movement of spermatozoa. Preservation of antifibrinolytic concentration in the tissues of the body is 17 hours, and in plasma - about 7-8 hours. Metabolism is exposed only to a small extent. From the body the drug is excreted by the kidneys for 12 hours.

Indications for use

The main indications for the use of tablets Tranexam - a bleeding or the likelihood of their development due to:
    strengthening fibrinolysis of local manifestation, that is, uterine, nasal, gastrointestinal, hematuria, dental, gynecological and so on;
    strengthening of generalized fibrinolysis, namely because of the appearance of malignant neoplasms in the pancreas or prostate gland, surgical interventions on the chest, leukemia, postpartum hemorrhages, liver diseases;
    hereditary angioedema, allergic diseases, such as: eczema, urticaria, allergic dermatitis, rashes and irritations;
    bleeding during pregnancy;
    inflammatory diseases, for example: tonsillitis, pharyngitis, stomatitis, laryngitis.
The use of a solution for intravenous administration is recommended when:
    bleeding or the likelihood of their development due to increased fibrinolysis;
    surgical interventions on the bladder;
    operations with systemic inflammatory reactions, for example, sepsis, peritonitis, pancreonecrosis, gestosis of severe and moderate severity, various shock states and so on.

Contraindications

Before you buy Tranexam tabs, you should know that use of the drug is contraindicated when:
    subarachnoid hemorrhage;
    high sensitivity to it.
Care is required in the treatment of patients with thrombosis and the threat of their occurrence, thrombohemorrhagic complications, color vision disorders, hematuria from the upper parts of the urinary system, renal insufficiency.

Side effects

Side effects may develop with this drug. So, taking pills blood-stopping can feel nausea, vomiting, heartburn, diarrhea, rashes, itching, loss of appetite, dizziness and drowsiness. Also, the color perception is not ruled out, in rare cases there is thromboembolism and thrombosis.
As for the solution for the introduction of a vein, as a result of its use, it is possible to develop allergic reactions, dyspepsia, dizziness, weakness, drowsiness, tachycardia, chest pain, hypotension, color vision, blurred vision, thrombosis or thromboembolism, and so on.

Instructions for use of Tranexam (Method and dosage)

As a rule, tablets Tranexam instruction for use recommends taking inside.
The dosage and treatment regimen for various disorders is established by the attending physician, although there are standard prescriptions.
For example, the treatment of local fibrinolysis is carried out at the appointment of 1000-1500 mg to 2-3 times a day.
Therapy of profuse uterine bleeding includes taking the drug in a daily dosage of 1000-1500 mg to a 3-4-day intake for 3-4 days.
After surgical intervention of conization of the cervix, the tablets are taken in a daily dosage of 1500 mg to a 3-time take, on average, 12-14 days.
Solution of the drug or ampoules of Tranexam instructions for use recommends injecting into a vein. You need to do this by drip or jetting. For each indication, the doctor prescribes a certain dosage and duration of use. Therefore, the dose and duration of application of the drug with monthly differs, for example, from the appointment in the treatment of generalized fibrinolysis. There are also various situations in which dosage adjustment may be required already during the treatment period.

Tranexam with women periods

It should be noted that menstruation disorders occur quite often. This can be severe pain, heavy bleeding, cycle date malfunction. All this is not just unpleasant, but often it is the development of various disorders: inflammation, cysts, uterine fibroids, infections of the pelvic organs. At the same time, many women undergo thorough examinations and receive a doctor's appointment. In general, there are many hemostatic drugs. As the reviews on Tranexam show, with monthly it is prescribed in the form of tablets. The instruction for the preparation contains information on the dosage and duration of therapy - one tablet to 3-4 times a day for 3-4 days.

Tranexam with uterine bleeding

There are many cases where uterine bleeding caused iron deficiency, which is also a threat to human health and life. Therefore, in uterine bleeding, hemostatic tablets are prescribed, including Tranexam. Of course, without the doctor's appointment, this should not be done, since it is important to establish the causes of the violation, which can be very different.

Overdose

Information on overdose is not provided.

Interaction

Use with hemostatic drugs and hemocoagulase can stimulate thrombus activity.
The solution for the introduction into the vein has a pharmaceutical incompatibility with blood preparations, some solutions containing penicillin, urokinase, dipyridamole, diazepam, tetracyclines, some hypertensive drugs, for example, Norepinephrine, Metarnin bitartrate and Deoxyepinephrine hydrochloride.

special instructions

Before the beginning of the therapeutic process, an eye doctor should be examined to determine visual acuity, examination of the eye day and color perception.

Storage conditions

The place for storage of the drug does not require special conditions. For this it is important that it is not accessible to children, at temperatures up to 30 ° C.
Shelf life - 3 years.

Tranexam during pregnancy and lactation

This drug can be administered when bleeding occurs during pregnancy. Of course, you need to take the medicine only according to the indications, considering all the contraindications. It is known that the basic substance easily overcomes the placental barrier and enters the breast milk. Nevertheless, reviews of Tranexam during pregnancy from women who took this medication contain information that the treatment was uneventful.
Treatment of bleeding during pregnancy passes with the appointment of the drug in a daily dosage of 250-500 mg to a 3-4-time intake. The medication is taken until the bleeding completely stops, but usually the therapeutic course lasts 7 days.

Alcohol and Tranexam

Take alcohol during the treatment period is prohibited, since it has an undesirable effect on the blood condition.

Reviews of Tranexam

Especially often this drug is prescribed to women with the appearance of uterine bleeding. A large number of discussions of this medication is found in forums and in women's blogs. Judging by the reports of patients, it is this kind of treatment that helps to get rid of the problem quickly and fully. Thus, one patient was assigned Tranexam with Dufaston with a small detachment with concomitant bleeding. According to her, the effect of the medicine was quick and soon she felt normal. Therefore, it is difficult to immediately answer from what tablets and solution help best.
Quite often this drug is prescribed for menstruation. Patients confirm the rapid and trouble-free action of the drug and its high efficacy. As testimonials about Tranexam during pregnancy show, the treatment also helped stop bleeding and prevent the development of serious problems.
However, there are also negative reviews. For example, one woman writes that when she tried to transfer to contraceptives, bleeding occurred. It did not stop even after taking Tranexam prescribed by the doctor. Why did not the drug help the woman? There is a reasonable explanation for this: because it can not influence the causes of bleeding, but only affects this symptom.
Numerous doctors' reviews of Tranexam once again remind that if bleeding has begun, self-treatment is dangerous. In case of bleeding it is important to call an ambulance in a timely manner or to reach the polyclinic yourself.