Trental 100mg #60

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Trental instruction for use

Tablets Trental represent a group of pharmacological agents that improve blood microcirculation. They are used in various pathologies, accompanied by a significant deterioration of local blood flow in the vessels.

Description of dosage form, composition

Tablets Trental have a round shape, biconvex surface, they are covered with enteric film coating of white color. The main active ingredient of the drug is pentoxifylline, its content in the 1st tablet is 100 mg. It also includes auxiliary additional substances, which include:
    Colloidal silicon dioxide.
    Titanium dioxide.
    Lactose.
    Macrogol.
    Talc.
    Copolymer of methacrylic acid.
    Starch.
    Sodium hydroxide.
Tablets Trental 100 mg packaged in a blister for 10 pieces. Cardboard pack contains 6 blisters (60 tablets), as well as instructions for the use of the drug.

Pharmacological effects, pharmacokinetics

The main active ingredient of Trental pentoxifylline tablets is a chemical derivative of xanthine. It suppresses the activity of the phosphodiesterase enzyme, which leads to the accumulation of cGMP (cyclic guanine monophosphoric acid) in the cells, which causes relaxation of the smooth muscle of the vessel walls with an increase in the diameter of their lumen, and also improves the elasticity of the plasma wall of erythrocytes, which allows them to pass well through the vessels of the microcirculatory bed. The drug slightly dilates the arteries of the heart (coronary vessels), as well as the structures of the brain.
After taking the tablet Trental 100 mg inside the active ingredient pentoxifylline quickly and almost completely absorbed into the blood from the intestine. It is evenly distributed in tissues, metabolized in the liver with the formation of inactive decay products, which are excreted in the urine.

Indications for use

Receiving tablets Trental 100 mg is indicated for the complex treatment of pathological conditions, accompanied by a primary impairment of peripheral blood flow, they include:
    Sclerotic lesions (deposition of cholesterol in the form of plaques on the internal wall of arteries with a violation of blood flow in it) peripheral arteries, which is often accompanied by intermittent claudication.
    Pathological vascular damage, provoked by long-term development of diabetes mellitus (diabetic angiopathy).
    Various circulatory disorders in the structures of the brain are the consequences of the prolonged development of cerebral atherosclerosis, characterized by the deposition of cholesterol in the arteries of the brain.
    Dystrophic changes in the structures of the middle and inner ear, provoked by deterioration of blood circulation in them.
    Various trophic disorders in the tissues, provoked by a violation of peripheral blood flow (trophic ulcers of the lower extremities, gangrene).
    States after a stroke of the brain.
    Various circulatory disorders in the retina or choroid of the eye.
Also, the drug is used for complex therapy of otosclerosis, accompanied by the replacement of connective tissues of various structures of the middle and inner ear against the background of circulatory disturbances in it.

Contraindications to use

The use of tablets Trental 100 mg is contraindicated in certain pathological and physiological conditions of the patient's body, which include:
    Volumetric bleeding of various localizations in the body.
    Acute myocardial infarction (death of the heart muscle).
    Extensive hemorrhages localized in the retina of the eye.
    Severe violations of the rhythm of contractions of the heart (arrhythmia).
    Hemorrhages in the tissue structures of the brain.
    Increased blood pressure (arterial hypertension), which is difficult to treat with drugs.
    Hypersensitivity to any chemical compounds of methylxanthine derivatives.
    Hypersensitivity to any of the components of the drug.
    Pregnancy at any time of the current, lactation (breastfeeding).
With caution, this drug is used in patients with concomitant increase in blood pressure, which is amenable to drug control, marked violation of the functional state of the liver and kidneys, chronic insufficiency of the contractile function of the heart, a violation of hemostasis (coagulating blood system), which is accompanied by increased tendency to bleeding, including number and against the background of the use of drugs of the pharmacological group, indirect anticoagulants, and also after the transfer hay in the recent past surgeries. Before prescribing the drug, the doctor must be sure that there are no contraindications.

Correct use, dosage

Tablets Trental 100 mg are intended for oral administration (oral administration). They are taken during or after meals, they are not chewed, swallowed whole and washed down with enough water. The doctor sets the average therapeutic dosage of the drug individually. Usually start with 100 mg (1 tablet) 3 times a day. If necessary, the dosage gradually increases to 200 mg 2-3 times a day. The maximum single dose should not exceed 400 mg. Dosage for patients with a decrease in the functional activity of the liver, kidneys, controlled by the increase in blood pressure usually decreases by a factor of 2. The duration of the course of therapy with the use of tablets Trental is set by the doctor individually.

Negative adverse reactions

Against the background of the reception of tablets of Trental with different frequency, patients can develop negative pathological reactions from some organs and systems:
    Digestive system - marked decrease in the tone (atony) of the intestinal wall, lack of appetite (anorexia), dry mouth (xerostomia).
    Nervous system - headache, periodic dizziness, sleep disturbances, spasms of striated skeletal musculature, anxiety.
    Cardiovascular system - pain in the heart (cardialgia), rhythm disturbance (arrhythmia), cardiac contractions, tachycardia, decrease in the level of systemic arterial pressure (arterial hypotension).
    The sense organs are a visual impairment, the appearance of a blind spot in the field of vision (scotoma).
    Skin and subcutaneous tissue - increased brittleness of the nails, reddening of the skin of the upper body with sensations of hot flushes.
    Blood and red bone marrow - a decrease in the number of leukocytes (leukopenia), platelets (thrombocytopenia), a violation of blood clotting with the development of bleeding in the skin, mucous membranes of the hollow structures of the digestive tract, a decrease in the concentration of fibrinogen (hypofibrinogenemia) in plasma.
    Allergic reactions - the appearance of a rash on the skin, its itching, redness, characteristic changes, which in appearance resemble a nettle burn (urticaria), pronounced swelling of the soft tissues of the face and external genital area (angioedema of Quincke), severe systemic reaction with a critical decrease in the arterial pressure and the development of multiple organ failure.
The appearance of signs of the development of negative pathological reactions is the basis for stopping the use of Trental tablets and contacting a doctor.

Features of use

Prior to the appointment of Trental 100 mg tablets, the doctor must take into account a number of characteristics with regard to the correct use of this medication, which include:
    In case of using the drug in patients with the corresponding diabetes mellitus, it is necessary to control the blood sugar level and, if necessary, to adjust the dosage of insulin or hypoglycemic drugs.
    During the course of therapy, periodic monitoring of systemic arterial pressure is mandatory.
    Simultaneous use of drugs in the pharmacological group of anticoagulants requires mandatory laboratory monitoring of the functional state of the blood coagulation system.
    The drug is used with caution in the elderly, they usually require a reduction in dosage.
    Patients who received the drug after a recent surgery needed laboratory monitoring of hemoglobin and hematocrit.
    Smoking can lead to a decrease in the therapeutic effect after taking the tablet Trental.
    The active ingredient of this medication can interact with preparations of other pharmacological groups, therefore one should be warned about their possible use by the attending physician.
    During the taking of tablets, it is not recommended to perform work that is associated with the need for increased concentration of attention and sufficient speed of psychomotor reactions.
In the pharmacy network, Trental tablets are sold as a prescription drug. Their independent use is not recommended, as this can lead to various complications and consequences.

Excess dose

Overdose with tablets Trental leads to significant weakness, nausea, dizziness, changes in the functional state of the cerebral cortex with drowsiness or excitation, loss of consciousness, development of seizures of striated skeletal muscles, increased body temperature, decreased systemic blood pressure, increased heartbeats. In this case, symptomatic therapy is carried out in the conditions of a medical hospital, as well as measures aimed at maintaining the vital functions of the body.

Proper storage

The shelf life of Trental 100 mg tablets is 4 years. They should be stored in the original factory packaging, dark, dry, inaccessible to children at an air temperature of +8 to +25 ° C.