Valacyclovir tabs 500mg #10

Valacyclovir instruction for use

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Composition

In the composition of one tablet is 556 mg Valacyclovir hydrochloride (500 mg in terms of Valacyclovir).

Form release

Pills in plastic shell, carton boxes or glass jars 10 pieces.

Pharmacological action

Antiviral.

Pharmacodynamics and pharmacokinetics

The active substance of the drug inhibits the activity of DNA polymerase of herpes viruses, prevents the synthesis of viral DNA and inhibits replication processes.
After getting into the body, Valacyclovir is transformed into acyclovir and L-valine, then phosphorylation reactions occur and acyclovir is converted into acyclovir triphosphate. The resulting compound is capable of suppressing DNA polymerase of a malicious agent (virus) through a competitive mechanism.
Phosphorylation usually occurs in two stages. On the first reaction catalyzes enzyme timidinkinaza. The drug is particularly active against Herpes simplex, Varicella zoster, it is less sensitive. The substance is excreted by the kidneys or feces, the half-life is approximately three hours.

Indications for use

The medicine is prescribed:
to treat diseases of the mucous membranes and skin caused by herpes simplex virus;
to prevent recurrence of diseases caused by the same virus;
with shingles;
as prevention of cytomegalovirus infection after organ transplantation.

Contraindications

The product is contraindicated:
bone marrow and kidney transplantation;
in case of Allergy to the active substance;
HIV-infected, if CD4+-lymphocytes do not exceed 100 MK/l;
children up to 18 years (with the exception of transplant organs, then the drug is used to 12 years).

Side effect

The drug is well researched. As a result of laboratory studies and observations of patients with shingles and herpes virus (including the accompanying immune deficiency) receiving Valacyclovir were identified in almost all the possible side effects.
Possible:
nausea, epigastric pain, vomiting, anorexia and diarrhea, increased liver enzyme activity, hepatitis;
disorders in the kidneys, photosensitivity, shortness of breath, thrombocytopenia;
headaches, dizziness, hallucinations, depression, agitation, ataxia, psychosis, dysarthria, impaired consciousness and coma;
rash, itching, anaphylaxis, urticaria, Quincke edema;
neutropenia, aplastic anemia, vasculitis, thrombocytopenia;
nasopharyngitis, swelling of the face, tachycardia, increased blood pressure, fatigue;
runny nose, fever, and dehydration.

Instructions for use Valacyclovir (Method and dosage)

The tool is taken inside, regardless of the meal.
Valacyclovir tablets, instructions for use
When shingles single dosage is 1000 mg (2 tablets), 3 times a day. The course of treatment is 7 days. The sooner after the first symptoms of the disease started taking the drug, the more effective treatment will be.
Herpes (including prophylactic dose) daily dose – 1000 mg. is Recommended divided into 2 doses, morning and evening, one pill. Duration of treatment - from 5 to 10 days (severe disease).
If the patient has impaired renal function, the dose should be adjusted.

Overdose

There is no evidence of an overdose of the drug.

Interaction

Clinically significant cases of interaction of tablets with other drugs were not observed.
However, the active substance is excreted through the kidneys by tubular secretion. Any medication that will be prescribed at the same time Valacyclovir, will interfere with its normal excretion from the body. First of all, this applies to Cimetidine and other drugs that block the mechanism of tubular secretion.
When combined with Mycophenolate, the concentration of acyclovir in the blood plasma increases.
When combined with cyclosporine, Tacrolimus and drugs that violate the normal functioning of the kidneys, the load on these organs increases.

Terms of sale

The prescription is not needed to buy Valacyclovir online.

Storage conditions

In a cool place, at a temperature no higher than 25 degrees.
Shelf life - 2 years.

Special instruction

In disorders of the kidneys to use the drug should be with caution. Perhaps the development of acute renal failure, disorders of the Central nervous system.
For elderly patients dose adjustment is not required, however, should increase the amount of liquid consumed.
During treatment for genital herpes should refrain from sexual intercourse, as the drug does not save from transmitting the virus to the partner.
In the treatment of patients with liver diseases should be careful.
There is no clinical experience of using the drug for children under 12 years, in this regard, the drug is not prescribed to children.
If the patient had a bone marrow or kidney transplant, found a clinically significant form of HIV infection, manifested acute immunodeficiency, taking the drug can lead to thrombocytopenic purpura, hemolytic-uremic syndrome and death.
If during treatment, the drug is observed hallucinations, convulsions, agitation, confusion and delirium, the drug should be discontinued.

Which is better: Valacyclovir or he needs therapy with valtrex?

He needs therapy with valtrex the imported analogues with the same active ingredient. The efficacy and frequency of adverse reactions drugs are identical. However, the cost far exceeds the he needs therapy with valtrex Valacyclovir.

Pregnancy and lactation

There are practically no studies that prove the harmlessness of the product for pregnant and lactating women. In this regard, the doctor should prescribe the drug.
Valacyclovir (its metabolite Aciclovir) penetrates well into breast milk.
During the studies in rats and rabbits, administration tool, it did not exert teratogenic effects, does not cause fertility in females and males.

Reviews of Valacyclovir

The reviews are good. The drug eliminates herpes for a long time, from side effects, nausea and problems with the gastrointestinal tract are most often manifested. Many people are satisfied with the relatively low cost of the drug.