Axamon tabs 20mg #50

Axamon instruction

Reed more and buy Axamon online

Composition

In 1 tablet of ipidacrine hydrochloride 20 mg.
Ludipress, carboxymethyl, sodium starch, calcium stearate, - as auxiliary substances.

Form of issue

Pills.

pharmachologic effect

Stimulation of neuromuscular transmission.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Cholinesterase inhibitor. By blocking the potassium channels of the membranes, elongation of the excitation time in the presynaptic fiber results in the release of an increased amount of acetylcholine.
And inhibiting the activity of cholinesterase, stimulates neuromuscular transmission. Under the influence of ipidacrine, the action of acetylcholine, histamine, oxytocin, adrenaline, and serotonin on smooth muscles is enhanced.
Has effects:
    improves conduction in the peripheral NA, which was disturbed by trauma, exposure to antibiotics, local anesthetics, potassium chloride;
    has a sedative and analgesic effect, which is due to the effect on Na-channels;
    indirectly through the effect on acetylcholine, adrenaline, serotonin, histamine and oxytocin receptors causes contractility of smooth muscle organs;
    inhibits the development of dementia, improves memory;
    does not have teratogenic, mutagenic, carcinogenic and embryotoxic effects. Does not affect the function of the endocrine system.

Pharmacokinetics

Quickly absorbed and after 25-30 minutes the maximum concentrations in the blood are noted. 40-55% binds to blood proteins. Rapidly penetrates into tissues and is rapidly metabolized in the body. The half-life is 0.7 hours. It is excreted by the kidney and adrenal mechanisms.

Indications for use Axamon

    neuritis, polyradiculoneuropathy, polyneuritis and polyneuropathy;
    disorders of swallowing, chewing and speech (bulbar paralyzes);
    lesions of the central nervous system, which are accompanied by motor disorders;
    myasthenia gravis and myasthenic syndromes;
    Alzheimer's disease;
    demyelinating diseases;
    senile dementia;
    atony of the intestine.
Indications for use include the use of the drug also in case of weakness in labor activity.

Contraindications

Axamon is contraindicated in:
    epilepsy;
    hypersensitivity;
    extrapyramidal disorders accompanied by hyperkinesis;
    propensity to vestibular disorders;
    angina and bradycardia;
    bronchial asthma;
    peptic ulcer in the stage of exacerbation;
    obstruction of the intestine or urinary tract;
    pregnancy, lactation.
    thyrotoxicosis;
    age to 18 years.

Side effects

Axamon can cause unwanted reactions:
    nausea, vomiting, anorexia, hypersalivation, increased peristalsis, diarrhea;
    ataxia, dizziness;
    skin itching, rash;
    bradycardia;
    bronchospasm.

Instructions for use Axamon (Method and dosage)

Tablets are used inside.
Treatment of atony of the intestine - 15-20 mg 2 times. In diseases of the peripheral nervous system -20 mg three times.
In Alzheimer's disease, 10-20 mg three times a day. Duration of treatment up to 1 year.
When myasthenia gravis and demyelinating lesions 20-40 mg 4-5 times. The MS dose can be 200 mg.
For the purpose of stimulation of labor, only 20 mg. You can repeat the reception at intervals of 1 hour.
Instructions for use Axamon contains a warning that during treatment it is contraindicated to drink alcohol.

Overdose

Overdosage is manifested by symptoms: drowsiness and general weakness, bronchospasm, lachrymation, decreased appetite, vomiting, jaundice, severe sweating, nystagmus, miosis, increased peristalsis of the gastrointestinal tract, bradycardia, arrhythmias, decreased blood pressure, anxiety, agitation, anxiety, ataxia, convulsions, speech disorders , a coma.
Treatment: the use of holinoblokatorov (Metacin, Atropine, Cyclodol).

Interaction

Weaken the action of aminoglycosides, potassium chloride, local anesthetics. Strengthens the effects of drugs that depress the central nervous system.
Side effects are exacerbated by the appointment of other cholinesterase inhibitors.
The use of beta-blockers leads to increased bradycardia.
The use of other cholinergic drugs causes a cholinergic crisis in patients with myasthenia gravis.
Ethanol enhances unwanted effects.
The drug is compatible with nootropic drugs.
Atropine and Metacin reduce the symptoms of overdose.

Storage conditions

At temperatures up to 25 ° C.
Shelf life - 2 years.

Reviews about Axamon

The main indication for Axamon is Alzheimer's disease of an easy and moderate stage. Ipidacrin enters the brain, it mainly accumulates in the cerebral cortex and hippocampus, which are susceptible to injury in this disease. The effect of the drug depends on the dose.
In diseases of the peripheral nervous system, the effect was noted in 82.9% of patients. Successfully used with neuropathy of the facial nerve (in complex therapy), while nerve degeneration with the formation of contractures of facial muscles was not noted.
In patients with myasthenia gravis decreased ptosis, fatigue of mimic muscles and weakness.
Reviews of Axamon also concern the administration of this drug for cognitive impairment (memory impairment), encephalopathy, and polyneuropathy. In all these cases, the drug was effective, but the treatment was lengthy.
"The drug does not help right away. The result was discovered at the end of the course of treatment "
"... a very worthy replacement for dear Reminel and Exelon"
The drug is characterized by good tolerability - this distinguishes it from other acetylcholinesterase inhibitors. Treatment often was not accompanied by serious complications. The most common side effects were nausea, heartburn, epigastric pain and dizziness. These undesirable effects depend on the dose. After the discontinuation of the drug with a re-appointment, it was tolerated well. There are individual reviews that the drug caused excitement and insomnia.