Caffeine sodium benzoate tabs 100mg #10

Caffeine sodium benzoate instruction for use

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Composition

The composition of 1 tablet of the drug Sodium caffeine-benzoate may contain 100 mg or 200 mg of caffeine. Additional substances: calcium stearate, potato starch.
In 1 ml solution of the drug Sodium caffeine-benzoate contains 200 mg of caffeine. Additional substances: water, sodium chloride.

Form of issue

6 or 10 tablets in a box;
6 or 10 tablets in a cell-free package;
1 ml of solution in ampoules; 10 ampoules in a pack of cardboard.

pharmachologic effect

Psychostimulating, cardiotonic, analeptic action.

Pharmacodynamics and pharmacokinetics

The pharmacopeia classifies the present medicine as analeptic and psychostimulating. The methylxanthine derivative. It inhibits peripheral and central adenosine receptors in a competitive way. It inhibits the activity of phosphodiesterase in the heart, nervous system, skeletal muscles, adipose tissue, smooth muscle organs, increases the accumulation of cGMP and cAMP in them (when used only in large doses). It activates the respiratory and vasomotor centers of the midbrain, as well as the nucleus n.vagus, has a direct stimulating effect on the cortex. In high doses, it improves interneuronal conduction, strengthening reflexes at the level of the spinal cord.
Stimulates physical and mental performance, activates mental activity, motor activity, reduces reaction time, reduces fatigue and drowsiness for a while. When administered in small doses, the effect of neurostimulation predominates, and in large doses, the suppression of the nervous system predominates.
It makes the breathing deeper and increases its frequency. Usually has a positive chrono, batmo-, foreign and dromotropic effect. Stimulates the vasomotor nucleus and has a relaxing effect on the vessel wall, which causes the expansion of the arteries and veins of the kidneys, skeletal muscles, heart, and the tonus of the arteries of the brain increases.
The pressure changes under the influence of cardiac and vascular mechanisms of action of caffeine: at normal pressure, caffeine does not change or slightly increases it, with initially reduced - it normalizes it.
Has a relaxing effect on smooth muscles (including bronchi), and on skeletal - stimulating. Strengthens the secretory function of the stomach. Has a diuretic effect, which is caused by a decrease in the reverse absorption of sodium ions and water molecules in the renal tubules, as well as relaxation of the walls of the kidney vessels and increased filtration in the glomerulus of the kidneys. Reduces platelet aggregation and histamine release from macrophages. Stimulates the processes of glycogenolysis and lipolysis.

Indications for use

    decrease in working capacity (physical and mental);
    disorders that occur with the suppression of nervous activity, cardiovascular and respiratory systems (including opioid analgesics and infectious diseases);
    spasms of cerebral vessels;
    drowsiness.

Contraindications

    organic lesions of the circulatory system (including pronounced atherosclerosis);
    arterial hypertension;
    increased excitability;
    old age;
    glaucoma;
    sleep disorders.

Side effects

    Disorders from the nervous system: anxiety, agitation, sleep disturbance, with prolonged use is not excluded addiction.
    Disorders from the circulation: pressure increase, arrhythmias, tachycardia.
    Digestive disorders: vomiting, nausea.

Instructions for Caffeine-Benzoate Sodium (Method and Dosage)

The solution in the ampoules is administered subcutaneously, and the tablets Caffeine-Benzoate Sodium are taken orally. Adults appoint 100-200 mg of the drug up to three times a day, and children - 25-100 mg also up to three times a day.

Overdose

Signs of an overdose: agitation, anxiety, motor anxiety, agitation, muscle twitching, tremor, hyperesthesia, epileptic seizures, scintillation scotoma, headache, ringing in the ears, confusion, insomnia, delirium, tachycardia, delirium, arrhythmia, frequent urination, hyperthermia, dehydration, vomiting, nausea.
Treatment of overdose: support breathing, oxygenation, hemodialysis, regulation of the balance of fluid and electrolytes, with epileptic seizures prescribe diazepam, phenytoin or Phenobarbital intravenously.

Interaction

When combined, the effects of hypnotics and anesthetics are reduced.
When combined, it is possible to increase the effects of analgesics-antipyretics, Naproxen, Salicylamide.
With the simultaneous use of estrogens, it is possible to increase and prolong the duration of action of caffeine due to inhibition of the isoenzyme CYP1A2.
When combined with adenosine, there may be a reduction in the increased number of cardiac contractions caused by the introduction of Adenosine; also the drug reduces vasodilation, associated with the action of Adenosine.
When combined with acetylsalicylic acid, it is possible to increase its absorption rate, bioavailability and concentration in the blood.
With the simultaneous use of Mexiletine reduces the clearance of caffeine and increases its content in the plasma by blocking the metabolism of the latter in the liver.
Methoxalen slows the withdrawal of caffeine with possible stimulation of its effect and the appearance of toxic action.
Because of the activation of microsomal enzymes under the influence of phenytoin, when it is taken together, there is an acceleration of the exchange and excretion of caffeine.
Terbinafine, ketoconazole and fluconazole moderately increase the concentration of caffeine in the blood.
With simultaneous intake of caffeine accelerates the absorption of ergotamine.

Terms of sale

Without recipe.

Storage conditions

Keep away from children. Store at temperatures up to 25 ° C.

Shelf life

5 years.

special instructions

The action on the central nervous system can be expressed by excitation or, conversely, inhibition, depending on its type.
It should be used with caution in patients with peptic ulcer disease.

Children

The drug is not used in children younger than 12 years.

For losing weight

Caffeine is often used for weight loss. This is due to a decrease in appetite and an increase in physical endurance when using the drug. Some nutritionists indicate the ability of caffeine to burn an additional 5 kg of weight per month on the background of intense physical training. It is worth remembering that uncontrolled use of the drug may cause undesirable side effects.

In pregnancy and lactation

The drug is not applied in specified periods.

Reviews of Sodium Caffeine-Benzoate

The reviews characterize the drug as an effective tool for preserving and improving performance when used in moderation. Always remember that uncontrolled use of the drug may lead to the development of an overdose and severe side effects.