Chlorprothixene tabs 15mg #30

Chlorprothixene instruction for use

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Composition

One tablet of Chlorprothixen contains 15 or 50 mg of hydrochloride (depending on the form of release).
Excipients: lactose monohydrate, calcium stearate, corn starch, talc, sucrose.
The composition of the shell of tablets: hypromellose, macrogol, spasprey M-1-1-6181, talc.

Release form

Coated tablets in blisters of 10 pieces. In a carton box there are three blisters.
There is also an option in drops and injection solution in 2 ml ampoules (50 mg), in packs of 10 and 100 ampoules.

pharmachologic effect

The drug is an antipsychotic (neuroleptic), which is due to the fact that it has a blocking effect on dopamine receptors. By blocking these receptors, the drug also has analgesic and antiemetic effects.
In addition, Chlorprothixen has antihistamine and hypotensive effects by blocking α1-adrenoreceptors, 5-HT2 receptors, and H1-histamine receptors.

Indications for use Chlorprothixen

Chlorprothixen is a sedative neuroleptic that has a wide range of indications, including:
    hangover withdrawal syndrome occurring in drug and alcohol addiction;
    psychoses, including manic states and schizophrenia, which proceed with anxiety, psychomotor agitation and agitation;
    behavior disorders in children;
    insomnia;
    excitement, hyperactivity, irritability, confusion among the elderly;
    pain (the drug is used with analgesics).

Pharmacodynamics and pharmacokinetics

When taken orally, the bioavailability of the drug Chlorprothixen is approximately 12%. The drug is rapidly absorbed from the intestines, and after 2 hours the maximum concentration of the drug is reached in the serum.
The half-life from the body is approximately 16 hours. The drug penetrates the placental barrier and is excreted in small quantities along with breast milk. Metabolites have no neuroleptic activity, excretion occurs with urine and feces.

Contraindications

The drug is contraindicated for use in:
    any central nervous system depression, including depression caused by opiates, alcohol or barbiturates;
    vascular collapse;
    coma;
    pheochromocytoma;
    diseases of the blood-forming organs;
    hypersensitivity to components present in Chlorprothixen.

Side effects

    For the digestive system: psychomotor inhibition, fatigue, mild extrapyramidal syndrome, dizziness may be observed. In some cases, there may be a significant increase in anxiety, which is most often manifested in schizophrenics or patients with mania.
    For the cardiovascular system: orthostatic hypotension, ECG changes, tachycardia are possible.
    For the digestive system: there is a possibility of cholestatic jaundice.
    For the hematopoietic system: possible leukocytosis, hemolytic anemia, agranulocytosis, leukopenia.
    For organs of vision: clouding of the lens and cornea may occur, followed by deterioration of vision.
    For metabolism: carbohydrate metabolism, increased sweating, weight gain and appetite may be disturbed.
    For the endocrine system: amenorrhea, gynecomastia, galactorrhea, weakening of libido and potency.
    Dermatological reactions: photodermatitis may appear, photosensitization.
    Effects caused by anticholinergic effects: accommodation disturbances, constipation, dysuria, dry mouth.

Instructions for use Chlorprothixen (method and dosage)

With hangover withdrawal syndrome caused by drug addiction or alcoholism
The daily dose of the drug in tablets is 500 mg and is divided into 2-3 doses. As a rule, the treatment continues for 7 days. When abstinence symptoms disappear, gradually reduce the dose. The daily maintenance dose is 15-45 mg, it is enough to reduce the risks of developing another binge and stabilize the patient's condition.

In psychosis, including manic states and schizophrenia

Treatment begins with a daily dose of 50-100 mg, the dosage gradually increases until the optimal effect is reached, usually up to 300 mg. For individual cases, the dosage should be increased to 1200 mg per day. The daily maintenance dose is approximately 100-200mg. As a rule, the daily dose of the drug is divided into two or three doses, it is recommended to use a lower dose in the daytime, and in the evening - a large part, due to the pronounced sedative effect of the drug.
For neurosis, depressive and psychosomatic disorders
Independently or as an adjunct to therapy with antidepressants, the drug is used for depression, and especially for conditions that are combined with anxiety. With psychosomatic disorders that are accompanied by depressive disorders and anxiety, as well as with neurosis, a daily dose of up to 90 mg can be prescribed. Usually the daily dosage is divided into several doses. Given the lack of drug dependence on the drug or the development of addiction to it, you can take Chlorprothixen for quite a long time without any particular risks.

Instructions for use for insomnia

An hour before bedtime, 15-30 mg of the drug is taken.

For pain

The drug is able to potentiate analgesic actions, so it can be used to treat patients suffering from pain. In such cases, the drug is prescribed together with analgesics, the dosage is 15-300mg.

Overdose

In case of overdose, the following symptoms may appear: hyper- or hypothermia, convulsions, extrapyramidal symptoms, drowsiness, shock or coma.
In the event of an overdose of Chlorprothixen, supportive and symptomatic treatment is performed. In the shortest possible time it is necessary to do a gastric lavage, the sorbent is also recommended. It is required to take measures that are aimed at maintaining the activity of the cardiovascular and respiratory systems. You can not use adrenaline, because it can cause a decrease in blood pressure. Extrapyramidal disorders can be stopped by Biperiden, and convulsions by Diazepam.

Interaction

Simultaneous administration of the drug with ethanol or preparations containing ethanol, as well as with anesthetics, hypnotics, sedatives, neuroleptic and opioid analgesics may enhance the inhibitory effect of Chlorprothixen on the central nervous system.
The drug enhances the action of antihypertensive drugs.
With simultaneous intake of Chlorprothixen with adrenaline, tachycardia and arterial hypotension can occur.
The drug reduces the threshold of seizure activity, therefore, for patients with epilepsy, an additional correction of the dosage of antiepileptic drugs is required.
Simultaneous use of the drug with haloperidol, metoclopramide, reserpine, or phenothiazines may cause extrapyramidal disorders.
The property of Chlorprothixen, which blocks dopamine receptors, also reduces the effectiveness of the drug Levodopa.

Terms of sale

The drug is available in pharmacies by prescription.

Storage conditions

Store medicine Chlorprothixen in a cool place with an ambient temperature of not more than 25 ° C and no light.

Shelf life

The drug is stored for 2 years.

special instructions

Chlorprothixen should be prescribed with caution to patients who suffer from parkinsonism, epilepsy, in the case of a tendency to collapse, with severe respiratory and cardiovascular insufficiency, diabetes mellitus, marked disorders of the kidneys and liver, prostatic hypertrophy, marked cerebral arteriosclerosis.
Taking the drug can cause a false positive result for the immunobiological pregnancy test using urine, changes in the QT intervals on the ECG, as well as an erroneous increase in the blood level of bilirubin.
The drug has a negative impact on activities that are associated with a high rate of physical and mental reactions - driving, working at height, servicing cars, and so on.
When treating with Chlorprothixen, it is recommended to avoid increased exposure to sunlight (insolation).

For children

For the correction of behavior disorders in children, the drug is prescribed at the rate of 0.5-2mg per kilogram of the child's body weight.

With alcohol

It is recommended to stop drinking alcohol during the course of drug treatment.

During pregnancy and lactation

If possible, Chlorprothixen should not be prescribed for treatment during pregnancy and lactation.

Chlorprothixene Reviews

Judging by the reviews of Chlorprothixene on the forums, it is an excellent hypnotic. As for his actions in psychosis, opinions diverge here - some believe that the drug (produced by Zentiva) does away well with psychosis, while others (most of them) believe that the drug is poorly suitable for these purposes. Basically, the opinions of those who said, from which the tablets Chlorprotiksen, boiled down to the fact that it is an excellent sleeping pill that helps with psychosis.
From the negative reviews can be identified drowsiness, which occurs after taking the drug and a slight inhibition. Some developed significant anxiety caused by hallucinations. But at the same time, the greatest number of reviews is positive.
Reviews of doctors about Chlorprothixen boil down to the fact that it is a good neuroleptic, but with strict indications for use. The drug should not be taken in conjunction with alcohol and the dosage should be strictly adhered to.