Convalis caps 300mg #50

Convalis user manual

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Composition

The composition of the drug Convalis is (based on one capsule): 300 mg gabapentin + corn starch, talc, lactose monohydrate, magnesium stearate, gelatin, titanium dioxide, yellow iron oxide.

Form of issue

The preparation is released in the form of yellow capsules of small size. Inside the capsule is a white or white-yellow powder.
The medicine is sold in packages of 30 or 50 pieces.

pharmachologic effect

Antiepileptic, analgesic.

Pharmacodynamics and pharmacokinetics

The active component of the agent in its structure is similar to gamma-aminobutyric acid, which is a neurotransmitter. The substance binds to the alpha-2-δ subunit of the calcium channels and stops the process of calcium flow through them. It is these channels that provide the transmission of a nerve impulse signaling pain.
Also, the agent further reduces glutamate-dependent neuronal death, increases the synthesis of GABA, reduces the release rate of neurotransmitters of the monoamine group.
At normal concentrations in blood plasma, the drug has no effect on other GABA receptors, benzodiazepine, glutamate and other receptors. With sodium channels, the substance does not interact.
If you increase the dosage of the drug, its bioavailability will be reduced. The maximum concentration in the blood plasma occurs 2-3 hours after admission. Biological accessibility is about 60%. Eating, even with a high fat content, does not affect the pharmacokinetic performance of the product.
Half-life is about 6 hours. The active substance does not have the ability to bind to plasma proteins.
The drug does not accumulate in the body, does not induce the induction of liver enzymes. The withdrawal from the body is through the kidneys with urine. However, in elderly patients, persons suffering from liver diseases, clearance of gabapentin is somewhat reduced.
Patients with impaired renal function, especially those undergoing hemodialysis periodically, should adjust the daily dosage.

Indications for use

Convalis is appointed:
    with epilepsy for adults and children from 12 years as part of a comprehensive treatment or as an independent tool;
    for the treatment of neuropathic pain;
    with epileptic seizures with secondary generalization.

Contraindications

Capsules can not be used:
    children under 12 years;
    with acute pancreatitis;
    Persons with lactose intolerance, lactase deficiency and glucose-galactose malabsorption;
    if there is an allergy to the components of the drug.
Patients suffering from kidney failure should be careful when taking the medication.

Side effects

When using a drug to treat neuropathic pain, you may experience:
    ataxia, memory loss, confusion, drowsiness, tremor, dizziness, hyposthenia;
    diarrhea, constipation, indigestion, excessive gas formation, abdominal pain, dry mucous membranes, nausea;
    rashes on the skin, amblyopia, shortness of breath;
    general weakness, headache, asthenia, puffiness, weight gain.
If the drug is prescribed for the treatment of partial seizures, then the following side effects develop:
    leukopenia, purpura;
    lability of arterial pressure, vasodilation, inflammatory processes in the mouth (dental and gum disease);
    acne, rashes and itching on the skin;
    gingivitis, constipation, diarrhea, increased appetite and indigestion, nausea, flatulence, pain in the epigastric region;
    pain in the back, inflammation of the muscle tissue, arthralgia, brittle bones;
    dizziness, problems with tendon reflexes, anxiety, depression, depression, nystagmus, disturbance of thinking;
    runny nose, cough, pneumonia;
    development of infections of the genitourinary sphere;
    hyperkinesis, paresthesia, amnesia, confusion and movement coordination disorders, dysarthria, insomnia, tremor;
    decreased libido and impotence;
    impairment of visual acuity, diplopia, fatigue, facial swelling and periphery, asthenia.
Such undesirable reactions as ataxia, dizziness, nystagmus and drowsiness, depend on the dose taken.
There were also reports of the development of acute kidney failure, pancreas, gynecomastia, mastopathy, hallucinations. In some groups of patients, dystonia, dyskinesia, thrombocytopenia, palpitation, tinnitus, anuria are possible.
With a sharp discontinuation of taking pills, there may be signs of withdrawal syndrome: nausea, pain in different places, sweating, anxiety, sleep disturbance.

Instructions for the use of the Convalis (Method and dosage)

The medication is taken orally, without chewing and not sharing the pill, regardless of the food.
Instructions for the use of the Convalis as a cure for epilepsy
The initial dosage is 300 mg per day. Then, the daily dose is increased to 900 mg, distributed at regular intervals. Subsequently, if necessary and on the recommendation of the attending physician, the amount of the drug per day can reach 1200 mg.
The maximum amount of gabapentin that can be consumed during the day is 3600 mg (every 8 hours). The interval between receptions is no more than 12 hours.
Treatment of Neuropathic Pain
On the first day 300 mg of the drug are taken, in the second 600 mg for 2 doses, for the third 300 mg, 3 times a day. Further, the daily dosage can be increased to 3600 mg.
With kidney disease:
    if the creatinine clearance is 50 to 79 ml per minute, then you can drink 600-1800 mg of the drug per day;
    if the SC from 30 to 49 ml / min - up to 900 mg per day;
    if the clearance is up to 30 ml / min - 600 mg;
    with a clearance of less than 15 ml per minute, you should adhere to a dosage of 300 mg per day.
In patients who are on hemodialysis, after each 4-hour session should additionally take 300 mg of the drug.
In days when dialysis is not performed, an increase in the daily dose is impractical.

Overdose

Abuse of this drug may cause dizziness, diarrhea, diplopia, dysarthria and drowsiness.
As therapeutic measures to eliminate unwanted effects, gastric lavage is prescribed in the first hours after an overdose; reception of enterosorbents; symptomatic therapy. Effective hemodialysis is effective.

Interaction

Cimetidine increases the period of excretion of gabapentin from the body.
Simultaneous reception of the drug with oral contraceptives containing ethinyl estradiol or norethisterone does not cause their drug interaction.
Combination of the drug with morphine, if morphine was taken 120 minutes before gabapentin, leads to the prolongation of AUC funds by 50% and increased pain.
With the simultaneous administration of the drug with other anticonvulsants (Phenobarbital, Valproic Acid, Carbamazepine, Phenytoin), no interaction between drugs occurs.
Antacids, which contain aluminum or magnesium, reduce the bioavailability of the drug. Receive these funds should be with an interval of 2 hours.
The combination of the drug with ethanol can exacerbate side effects.
A joint administration with Naproxen leads to an increase in the absorption time of the Convalis.

Storage conditions

Store tablets in a cool, dark place, away from small children.
Shelf life - 3 years.

special instructions

Sometimes after starting the drug for people suffering from diabetes, it may be necessary to adjust the dosage of hypoglycemic agents.
When analyzing urine for protein content using litmus paper, the results may be distorted. It is recommended to make tests using any other method.
It is not recommended to drive a car or perform actions that require high concentration if you are taking the Convalis.
If, during therapy, the agent has recognized acute pancreatitis, treatment should be discontinued.
Cancellation or replacement of tablets should be done gradually, within 7 days due to an increased risk of seizures.
It is also recommended to make timely monitoring of a patient's mental state. During therapy, the risk of developing depression, the occurrence of suicidal thoughts and actions increases.

In pregnancy and lactation

Use the drug during pregnancy can only be recommended by a doctor. Data on the use of the drug by pregnant women are limited.
It is recommended to stop breastfeeding.

Reviews of Convalis

About the drug respond well, mainly in the treatment of epilepsy. Of the side effects most often manifested headaches, nausea and digestive problems. Also complain of the occurrence of withdrawal syndrome with a sharp discontinuation of taking tablets.
Reviews of the Convalis on the forums:
    "... A very good drug, however, take it long and adhere to the prescribed treatment regimen";
    "... I'm suffering from a herniated intervertebral disc, I felt much better on the Convalise, could walk much, was more active. But after the end of the course the pain returned ";
    "... Neuropathic pain sensations remain at the same level. It's true that after 2 or 3 hours after you can sleep for 3-4 hours. "