Ginkgo Biloba 40mg #40

Instruction for Ginkgo Biloba

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In Japan, Korea, China, the relict ginkgo tree is considered a symbol of perseverance and longevity. The extract of the leaves of the ginkgo tree feeds the brain, gives clarity of consciousness, improves memory, activates thought processes and slows down the aging of the brain. Supplements based on it - one of the most popular, their annual sales in the world exceed a billion dollars.
Among the biologically active additives for the normalization of cerebral circulation on the basis of the extract of ginkgo, one of the most popular is Ginkgo Biloba Evalar. Actively acting on the vessels of the brain, improving the rheological properties (fluidity) of blood, the extract of ginkgo contributes to the normalization of its blood supply and increase mental capacity for work. It is no coincidence that more than 60% of elderly patients in Germany and more than 70% in France constantly take supplements based on the extract of ginkgo!

Ginkgo Biloba Evalar promotes:

    improvement of cerebral circulation;
    increase mental capacity;
    improving memory and attention;
    decrease in meteosensitivity;
    supplying brain cells with oxygen and nutrients.
    In each tablet, Ginkgo Biloba Evalar is 40 mg of the German standardized extract of ginkgo biloba with a high content of active substances.

Composition

Composition of Ginkgo Biloba Evalar:

    dry extract of Ginkgo Biloba leaves;
    Glycine.
1 tablet Ginkgo Biloba Doppelherz contains:
    dry leaf extract - 30 mg;
    vitamin B1 - 1.4 mg;
    vitamin B2 - 1.6 mg;
    vitamin B6 - 2.0 mg.

Form of issue

Preparations based on Ginkgo Biloba are usually presented in the form of tablets from the leading pharmaceutical companies with various auxiliary components and biological additives:
Evalar supplies capsules or tablets of 40 pieces in plastic bottles of dark color. One vial of the oral form of the drug is put in the pack.
pharmachologic effect
Wikipedia defines the tree of Ginkgo as a gymnosperm relic plant, like spruce and pine, which is often called a living fossil. Fried seeds and boiled leaves as a tea have long been used for food in the areas of its growth and in Chinese folk medicine. At the end of the 20th century, the tree of Ginkgo Biloba became actively used in traditional pharmacy because of biologically active substances (bioflavonoids, terpenic trilactones, alkaloids, organic acids, proanthocyanides, flavonoids) isolated from its leaves. In addition, the plant contains a large number of micro- and macro elements.
The therapeutic properties of preparations based on Ginkgo are diverse, however, most often medicines are used due to vasoactive pharmacological effects. The constituent components are able to inhibit the activity of the phosphodiesterase enzyme, as a result of which cyclic guanosine monophosphate (cGMP) accumulates in the smooth muscle cells, and the concentration of calcium ions in the cytoplasm decreases. This manifests itself in relaxing the muscular wall of the vessels and reducing its tone. In addition, the action of the leaf extract extends to the endothelium, enhancing the synthesis of the relaxing factor, which provides a significant improvement in blood flow, including renal and cerebral blood flow.
Biological components of the pharmaceutical drug also affect the blood system, changing its rheological properties, preventing the development of thromboses, reducing the adhesive properties of erythrocytes and platelets, reducing the release of mediators that increase the tone of arterial blood vessels. The mechanism of antiplatelet action is inhibition of FAT activity (platelet activation factor).
Ginkgo Biloba has a strong antioxidant effect, which is realized due to various biochemical interactions. First of all, in this key is worth noting flavonoid glycosides. Possessing P-vitamin activity, they are able to bind to ions of copper, iron, manganese and other metals, forming complex compounds and reducing the concentration of free radicals. In addition, they prevent the biological destruction of ascorbic acid and adrenaline. Also, the extract contains terpenoids, copper, selenium, potassium and phosphorus, which realize other mechanisms of antioxidant effect.
The anti-ischemic properties of bilobalide, one of the active components of the extract of Ginkgo leaves, causes the use of a pharmaceutical in cardiology and the treatment of vascular insufficiency. This ability of the active substance is especially well realized under conditions of hypoxia, as the activity of cytochrome-C oxidase is maintained due to increased mitochondrial expression and increase in mRNA level, which is manifested in an increase in the respiratory activity of mitochondria.
The plant can be used in neurology, because the drug possesses neuroprotective properties, reducing the risk of developing spontaneous and oxidative apoptosis by reducing the activation of NMDA receptors and their effect on calcium-dependent mechanisms of programmed cell death. In addition to directed action on the nerves, the drug contributes to the normalization of carbohydrate metabolism, affects the metabolic properties of norepinephrine, dopamine and serotonin, due to which the antidepressant and nootropic effects of the therapeutic agent are realized.
The use of the extract of Ginkgo Biloba is also advisable in nephrology, since the constituent components have protective properties in relation to the tissues of the kidney. The nephroprotective effect is realized through reduction of lipid peroxidation, which protects cellular structures from damage. The drug reduces proteinuria and severity of some other tubular disorders. Do not forget that the plant inherent diuretic properties, as well as renal blood flow is greatly improved, and the speed of glomerular filtration increases.

Pharmacodynamics and pharmacokinetics

Pharmacokinetic abilities of drugs, based on the active components of the extract of Ginkgo Biloba, have not been studied at this time.

Indications for use Ginkgo Biloba

    an unjustified sense of fear;
    encephalopathy;
    dizziness;
    atherosclerosis of cerebral vessels and myocardium;
    diabetic retinopathy;
    Raynaud's syndrome;
    hypochromic anemia;
    violation of the physiological rhythm of sleep and wakefulness;
    arteriopathy of the lower extremities;
    general malaise;
    dementia in the background of Alzheimer's disease;
    cerebrovascular disorders;
    as an additional source of polyphenols and flavonoids for their insufficiency.
Indications for use can be greatly extended by using pharmaceutical preparations based on Ginkgo Biloba in geriatrics. It is prescribed for senile macular degeneration and hypoacusia, mental disorders, neurosensory disorders, including noise in the ears, for improving memory and learning ability.

Contraindications to Ginkgo Biloba

Absolute contraindications to the use of a homeostatic agent:
    increased individual sensitivity to the components of the pharmaceutical product;
    acute disorders of cerebral circulation;
    peptic ulcer of the stomach and duodenum in the phase of exacerbation;
    decreased blood clotting;
    arterial hypotension;
    acute myocardial infarction;
    pregnancy and the period of breastfeeding;
    the age category is under 16 years.
Pathological conditions, when preparations based on Ginkgo can be used with caution, subject to constant medical supervision:
    epilepsy - the risk of seizures increases;
    erosive gastritis - the possibility of complications of the pathological process;
    planned surgical interventions or postoperative regimen - increased risk of profuse bleeding;
    if there are risk factors for intracranial hemorrhage.

Side effects

Usually, drugs based on Ginkgo Biloba are well tolerated by patients, since the plant nature of the pharmaceutical preparation is much closer to the natural, physiological dietary regime than the artificially synthesized constituents. In some cases, the following side effects may occur:
    digestive disorders;
    allergic reactions;
    headache.

Ginkgo Biloba, instructions for use (Method and dosage)

Instruction for Ginkgo Biloba Evalar

Tablets are taken orally inwards. Capsule is recommended to swallow whole, not crushing and not chewing, but with enough water. A pharmaceutical is used at the time of food intake, since the gastrointestinal tract is maximally tuned for absorption and the effectiveness of the therapeutic agent is then increased. The starting dosage is 1-2 capsules 1-2 times a day. The duration of the course of conservative treatment is selected individually, as a rule, the duration is at least 3 months. Repeated therapy may be given only after 2-3 months.

Overdose

The medical literature does not describe cases of an overdose of any form of the drug.

Interaction

Pharmaceutical preparations based on Ginkgo Biloba should not be used in combination therapy with drugs that have anticoagulant or antiaggregant activity, and non-steroidal anti-inflammatory drugs due to an increased risk of bleeding.

Storage conditions

Preparations with Ginkgo Biloba should be stored in a dry place, protected from light and inaccessible to children. The temperature should not exceed 25 degrees Celsius.
Shelf life - 2 years

In pregnancy and lactation

During pregnancy and breastfeeding the drug should be taken strictly according to the doctor's prescription.

Reviews of Ginkgo Biloba

Pharmaceutical preparations based on Ginkgo tree are very popular, because they are a kind of panacea in the treatment of a large number of nosological units. Therapeutic properties of a medicinal plant have been known since ancient times, which forms a special credit of trust to such a conservative sanitation uniting folk remedies and achievements of modern pharmacy.
Reviews of Ginkgo Biloba Evalar should be noted separately, because this is the most common drug based on this plant. A huge number of forums and thematic sites are full of recommendations on its use, especially since it does not require the knowledge and skills of a medical worker or a gardener, because many grow Ginkgo on their own, which consumes a lot of effort and time.
Also a positive aspect of the tablets is the gradual onset of pharmaceutical effects - such a time duration of therapy allows to fully adapt and adjust all necessary systems and metabolic chains, which affects the final favorable result.
The doctors' comments about Ginkgo Biloba are extremely ambiguous, as well as to most of the medicines, the active ingredient of which is the herbal component. Of course, some part of medical specialists approve the use of such a conservative sanation, as they independently observed the positive dynamics of pathological conditions in the patients being supervised.
However, a large proportion of qualified medical personnel remain deaf to such not entirely traditional means of treating nosological units. Of course, their argument is based on a small study of pharmaceuticals based on Ginkgo, short-term use, which in practical terms does not provide reliable conclusions about the long-term side effects or adverse effects of drug therapy. To refute the described cases of cure by means of Ginkgo Biloba they are also not capable, which once again points to the clinical effectiveness of not yet fully investigated mechanisms of action of the drug.