Proproten-100 #40

Proproten-100 Instruction manual

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The drug Proproten 100 contains antibodies to a specific protein of the human brain. It is used to treat alcohol dependence in light and moderate severity of this pathological condition.

Form of issue and composition

The drug Proproten 100 is available in 2 basic dosage forms - drops for oral administration and tablets. The main active component of the drug is purified antibodies to the brain-specific protein S-100 (their purification is carried out by affinity). The concentration of the active substance is 1 g in 100 g drops or 0.003 g in one tablet. The tablets also contain auxiliary components, which include magnesium stearate, lactose, microcrystalline cellulose. Drops Proproten 100 are in a 25 ml vial, the tablets are packaged in 10, 40, 50 and 100 pieces in a package.

Pharmacodynamics and pharmacokinetics

Brain-specific protein S-100 performs the function of information and exchange conjugation of brain cells (neurocytes), and also has an effect on certain centers involved in the formation of alcohol dependence (centers of the hippocampus, hypothalamus and other subcortical structures). Antibodies to this protein, which are the main active substance of Proproten 100, modify its functional activity. During the application of the drug, it has a number of therapeutic effects:
    Normalizes the activity of the system of positive emotional reinforcement, due to which the independent stimulation of the lateral centers of the hypothalamus decreases.
    Reduces the excessive activity of hippocampal centers.
    Reduces the concentration of specific immune active complexes in the blood, which has a certain correlation with a decrease in alcohol intake.
    Helps increase the effect of gamma-aminobutyric acid, which has a brake effect.
    Increases the resistance of brain tissue to lack of oxygen and toxins (neuroprotective effect).
Today it is proved that the preparation Proproten 100 also restores the balance of neurotransmitters of the tissues of the structures of the central nervous system, as well as conditioned reflex activity. There are no reliable data on absorption, distribution in tissues, metabolism and excretion of the active substance of the drug to date.

Indications for use

The only indication for the use of Proproten 100 is alcohol dependence. It is used as a monotherapy for the disease of mild and moderate severity of the pathological process. This drug shows an antialcoholic effect, and also reduces the severity of manifestations of withdrawal from the psyche (mental stress, anxiety, depression, irritability, insomnia, a pronounced desire for alcohol) and the autonomic nervous system (headache, hand tremors, worsening digestion, sweating, severe weakness).

Contraindications

Absolute contraindications to the use of Proproten 100 is an individual intolerance, as well as hypersensitivity to any of the components of the drug, pregnancy, lactation (breastfeeding).Dosage and route of administration

Regardless of the dosage form, Proproten 100 is intended for oral administration. 10 drops are dissolved in a 1-spoon of water (5-10 ml) and then taken, the tablet is absorbed in the mouth 20-25 minutes before meals. In the case of pronounced hangover syndrome, it is taken every half hour (10 drops or 1 tablet). After 8-10 hours after the last intake of alcohol, the drug should be taken every hour. If the patient is able to fall asleep, then the application is resumed after his awakening. Then during the next few days the drug is taken every 3-4 hours (4-6 times a day). With increasing intensity of manifestations of alcohol withdrawal, the use of the drug can be combined with activities and medications aimed at removing toxins from the body. To prevent the re-development of alcohol dependence, the drug is taken 1-2 times a day for 2-3 months.

Side effects

When used correctly, the drug Proproten 100 is well tolerated. Sometimes it is possible to develop reactions of intolerance to the active substance or auxiliary components.

special instructions

Since the preparation as an auxiliary component includes lactose, it should be applied with caution to persons with impaired digestion or absorption of carbohydrates (lactase deficiency, lactose intolerance, glucose-galactose malabsorption). In the pharmacy network, the drug is dispensed without a prescription. For better effectiveness of its use, you should consult your doctor in advance, as in some cases detoxification or use of medicines from other pharmacological groups may be required.

Overdose

To date, cases of overdose with the drug Proproten 100 in clinical practice have not been recorded.

Terms and conditions of storage

The shelf life of Proproten 100 is 2 years from the date of manufacture. It must be stored in a dark, dry place inaccessible to children at an air temperature of no more than + 25ºC.