Seyzar (Sazar) tabs 50mg #30

Seyzar user manual

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pharmachologic effect

Anticonvulsant. The mechanism of action is associated with the effect on the voltage-dependent sodium channels of the presynaptic membrane. This leads to a decrease in the release into the synaptic cleft of mediators, primarily glutamate, an excitatory amino acid, which plays an important role in the formation of epileptic discharges in the brain.

Pharmacokinetics

After oral administration, lamotrigine is rapidly and completely absorbed from the gastrointestinal tract. Cmax in plasma is reached after approximately 2.5 h. Plasma protein binding is 55%. Exposed to intensive metabolism with the formation of the main metabolite of N-glucuronide.
T1 / 2 in adults averages 29 hours. Excreted by the kidneys mainly as a metabolite; about 8% of the active substance is excreted unchanged.
T1 / 2 in children is less than in adults.

Indications

Partial and generalized tonic-clonic seizures (often in cases of resistance to treatment with other anticonvulsants).

Contraindications for Seyzar

Severe abnormal liver function, hypersensitivity to lamotrigine.

Application for violations of the liver

Contraindicated in severe violations of the liver.

Application for violations of renal function

Seyzar is used with caution in patients with renal insufficiency.

Use in children

Lamotrigine should not be used in children under 2 years of age.

Use in elderly patients

Lamotrigine should not be used in elderly patients.

Dosage and administration

When ingested for adults and children over 12 years old, the initial single dose is 25-50 mg, the maintenance doses are 100-200 mg / day. In rare cases, doses of 500-700 mg / day may be required.
For children aged 2 to 12 years, the initial dose is 0.2-2 mg / kg / day, supporting - 1-15 mg / kg / day.
The maximum daily dose of Seyzar for children aged 2 to 12 years, depending on the treatment regimen used, is 200-400 mg.
The frequency of admission, the intervals between doses with increasing doses depend on the regimen used, the patient's response to treatment.

Use Seyzar during pregnancy and lactation

Clinical data on the safety of lamotrigine during pregnancy and lactation are insufficient.
When deciding whether to use Seyzar during pregnancy, one should compare the expected benefit of therapy for the mother and the potential risk to the fetus.
Preliminary data show that lamotrigine penetrates into breast milk at a concentration of 40-45% of the concentration in plasma. A small number of infants whose mothers received lamotrigine did not have any side effects.

Side effects

From the side of the central nervous system: headache, dizziness, drowsiness, sleep disturbances, fatigue, aggressiveness, confusion.
On the part of the digestive system: nausea, abnormal liver function.
From the hemopoietic system: leukopenia, thrombocytopenia.
Allergic reactions: skin rash (usually maculopapular), angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis, lymphadenopathy.

special instructions

Seyzar is used with caution in patients with renal insufficiency.
Lamotrigine should not be used in elderly patients.
With the appearance of severe skin allergic reactions, lamotrigine should be discontinued.
With the sudden cancellation of lamotrigine may increase the manifestations of epilepsy, so you need to gradually stop treatment, reducing the dose over 2 weeks.
With simultaneous use with carbamazepine dizziness, diplopia, ataxia, visual impairment, nausea are possible. These phenomena, as a rule, pass with a decrease in the dose of carbamazepine.
Lamotrigine should not be used in children under 2 years of age.
Influence on ability to drive motor transport and control mechanisms
During the period of treatment, there is a slowdown in the speed of psychomotor reactions. This should be taken into account by persons engaged in potentially hazardous activities requiring increased attention and quick psychomotor reactions.

Interaction

With simultaneous use with anticonvulsant drugs - metabolism inducers in the liver (including phenytoin, carbamazepine, phenobarbital, primidone), lamotrigine metabolism accelerates. With simultaneous use of lamotrigine and carbamazepine or phenytoin, a decrease in T1 / 2 lamotrigine occurs. There are reports of dizziness, ataxia, diplopia, blurred vision and nausea in patients taking carbamazepine after starting lamotrigine.
Owing to the inhibition of liver microsomal enzymes under the influence of sodium valproate, lamotrigine metabolism slows down with simultaneous use, and lamotrigine T1 / 2 slows down.

Overdose

A single dose of doses exceeding the maximum therapeutic dose of 10–20 times was reported.
Symptoms: nystagmus, ataxia, impaired consciousness before coma.
Treatment: hospitalization and appropriate symptomatic therapy. In the case of a recent (less than 2 h) administration of Seyzar, it is necessary to conduct a gastric lavage.
Shelf life - 3 years.
Do not use after the expiration date printed on the package.

Storage conditions

You should store Seyzar in the dark place at a temperature of 15-25 ° C.
Keep out of the reach of children.

Terms of sell

You can buy Seyzar without a prescription.