Anastrozole tabs 1mg #30

Anastrozole user manual

You can buy Anastrozole on this page

Composition

One tablet of Anastrozole, regardless of the manufacturer, contains 1 mg of the active substance of the same name.
Additional components: povidone, lactose monohydrate, silicon dioxide, microcrystalline cellulose, magnesium stearate, sodium carboxymethyl starch.
The composition of the shell: macrogol-4000, hypromellose, titanium dioxide.

Release form

White round tablets, coated, biconvex shape, in the section you can see the core of white color and the shell.
Possible forms of release of the drug production ATOLL (Russia):
    ten or thirty tablets in an aluminum and PVC cellular packaging, 1-10 packages in a carton pack;
    10, 20, 30, 40, 50, 60, 100 or 120 tablets in a polymer can, one can in a carton pack.
Possible forms of production of the drug production FarmTekm SOTEKS (Russia):
    14 tablets in a blister, one or two blisters in a pack of cardboard.
Possible forms of release of the drug production BIOKAD (Russia):
    14 tablets in a cellular package, two such packages in a pack of cardboard;
    10 tablets in a cellular package, three such packages in a pack of cardboard.
Possible forms of release of the drug production HETERO DRUGS (India):
    thirty tablets in aluminum and PVC cellular packaging, one or two such packages in a carton pack;
    ten tablets in a cellular package, three or six such packages in a pack of cardboard.
Other forms of drug release are possible depending on the manufacturer.

pharmachologic effect

Antitumor, inhibits the synthesis of estrogen.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The tool is a powerful and highly selective non-steroidal aromatase blocker. In postmenopausal females, estradiol is produced by transformation in the tissues of the peripheral organs of androstenedione into estrone with the participation of the enzyme aromatase. Estron turns into estradiol.
Lowering estradiol causes a therapeutic effect in females suffering from malignant tumors of the breast. In postmenopausal use of 1 mg Anastrozole per day leads to a decrease in the estradiol content by 80%.

Pharmacokinetics

Rapid absorption of the drug, the highest concentration in the blood is reached after two hours when taken on an empty stomach. The half-life reaches 50 hours. Food slows down the speed of absorption.
Associated with blood proteins by 40%. Metabolized extensively. It is excreted by the kidneys in its original form 72 hours after ingestion. Metabolites are also excreted mainly by the kidneys.

Indications for use

    The first line of treatment for locally advanced malignant tumors of the breast in postmenopausal females.
    Adjuvant (adjuvant) treatment of early malignant tumors of the breast in the presence of positive hormone receptors in postmenopausal women.
    The second line of treatment for a common malignant tumor of the breast, after treatment with Tamoxifen, the disease progressed.

Contraindications

During the premenopause:
    severe liver failure;
    concurrent therapy with tamoxifen or estrogen containing agents;
    lactation period;
    pregnancy;
    childhood;
    sensitization to the components of the drug.
It is necessary to carefully prescribe a remedy for hypercholesterolemia, osteoporosis, coronary heart disease, liver failure, severe renal failure, lactose intolerance, lactase deficiency, glucose or galactose malabsorption.

Side effects

    Reactions from the cardiovascular system: hot flashes.
    Reactions from the musculoskeletal system: arthralgia.
    Reactions from the reproductive system: vaginal bleeding, vaginal mucosa dryness.
    Dermatological reactions: alopecia, rash, thinning hair, polymorphic erythema.
    Reactions from the digestive system: vomiting, nausea, diarrhea, anorexia, increased levels of ALT, AST and alkaline phosphatase, increased levels of gonadotropin and bilirubin, hepatitis.
    Reactions from the nervous system: drowsiness, headache, carpal tunnel syndrome.
    Metabolic reactions: hypercholesterolemia.
    Allergic reactions: urticaria, angioedema, anaphylactic shock.
    Other reactions: asthenia.

Instructions for use (method and dosage)

The instructions for Anastrozole, the instructions for Anastrozole Kabi and the instructions for Anastrozole Teva are fundamentally similar to each other. It is recommended to take the drug inside, swallowing it whole and washed down with a small amount of water. You should take the drug at the same time of day. Meal does not matter.
Anastrozole is administered one tablet a day for a long period of time. If there are signs of disease progression, the drug should be stopped. The recommended duration of therapy as an adjuvant is 5 years.

Overdose

Treatment: there is no specific antidote, symptomatic treatment is carried out. Vomiting can be induced if the patient is conscious. Dialysis is allowed. Supportive care, monitoring and control of vital systems and organs are recommended.

Interaction

There is no clinically significant pharmacological interaction when taking the drug at the same time as other drugs.
Drugs containing estrogens inhibit the pharmacological effects of anastrozole; therefore, they should not be taken together with Anastrozole.

Terms of sale

The prescription is not required to buy Anastrozole.

Storage conditions

    keep away from children;
    Store at temperatures up to 25 degrees.
Shelf life - three years.

special instructions

A number of adverse drug reactions may adversely affect the ability to drive a car.

For children

This drug is not intended for the treatment of children.

During pregnancy and lactation

The appointment of funds in these periods is contraindicated.

Anastrozole Reviews

Reviews of Anastrozole TL, reviews of Anastrozole Kabi and ordinary Asnastrozole repeat each other - the compositions of these drugs are the same. A number of patients noted subjective improvement, many complain about undesirable effects: hair loss, facial flushing, and nausea. It is difficult to say what these effects are associated with, since malignant diseases themselves have a strong toxic effect. Evaluation of the effectiveness of anticancer drugs should be carried out by a professional oncologist on the basis of modern laboratory and radiological diagnostic methods.

Anastrozole in bodybuilding

Anastrozole and other drugs inhibiting the production of estrogens are actively used in bodybuilding with long courses of steroid hormones, as well as to reduce the "negative" effect of female sex hormones on the results of training. Not worth it once again to talk about the possible side effects of the use of drugs of this kind is not on purpose.