AntiAngin formula spray 25ml

AntiAngin formula spray instruction

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Clinical and pharmacological group

The drug with antimicrobial and local anesthetic action for topical application in ENT practice and dentistry

Active substances

- chlorhexidine bigluconate (chlorhexidine)
- tetracaine hydrochloride (tetracaine)

Form of release, composition and packaging

Spray for topical use dosed as a colorless liquid with the smell of mint.
100 g
chlorhexidine bigluconate 0.12 g
tetracaine hydrochloride 0.06 g
Excipients: glycerol 85%, ethanol 96%, aspartame, mint aroma, propyl parahydroxybenzoate, citric acid anhydrous, purified water.
25 ml (100 doses) - plastic bottles with a dosing valve (1) - packs of cardboard.

pharmachologic effect

Chlorhexidine can have bactericidal and bacteriostatic effects. Has a broad antibacterial spectrum of action against Gram-positive and Gram-negative bacteria, is active against Candida albicans. Chlorhexidine is especially active against Streptococcus mutans, Streptococcus salivarius, Escherichia coli and anaerobic bacteria. Less effective against such microorganisms as Streptococcus spp., Proteus spp., Pseudomonas, Klebsiella spp., Veillonella spp.
Tetracaine has a local anesthetic effect.

Pharmacokinetics

Tetracaine is easily and completely absorbed through the mucous membranes. The binding with plasma proteins is high. Completely hydrolyzed by cholinesterase for 1-2 hours with the formation of para-aminobenzoic acid compounds. It is excreted by the kidneys and with bile, while it is partially subjected to hepatic intestinal recirculation.
There are no clinical data on the absorption of chlorhexidine through the mucous membrane of the human mouth. Chlorhexidine can persist in saliva until 8 hours. It is not practically absorbed from the digestive tract. It is excreted primarily through the intestine (90%), less than 1% is excreted by the kidneys.

Indications for AntiAngin formula spay

- prophylaxis, etiotropic and symptomatic treatment of infectious and inflammatory diseases of the oral cavity and pharynx caused by microorganisms sensitive to chlorhexidine (pharyngitis, tonsillitis, initial stage of angina, periodontal disease, stomatitis, gingivitis, condition after tonsillectomy or tooth extraction, etc.);
- complex therapy of angina (apply at the first signs of the disease - with pain in the throat and persheniya).

Contraindications for AntiAngin formula spay

- hypersensitivity to the components of Anti-Angin formula spay;
- damage or inflammation of the mucous membranes in the highly vascularized areas;
- phenylketonuria;
- Children's age (up to 10 years).
With caution: during pregnancy and lactation, with diabetes, a deficiency of glucose-6-phosphate dehydrogenase, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, oxalose and urolithiasis.

Dosage

Locally. Anti-Angin formula spay is sprayed on the mucous membrane of the mouth and throat when breathing is delayed.
Adults and children over 15 years: 1-2 injections at the reception up to 6 times a day.
Children from 10 to 15 years: 1-2 injections at the reception up to 3 times a day. The course of treatment is not more than 5 days.

Side effects of Anti-Angin formula spay

Allergic reactions, burning of the mucous membrane of the mouth.

Overdose

Symptoms of overdose: dizziness, general weakness, cyanosis, agitation, anxiety, muscle tremor, respiratory failure, nausea, vomiting.
Treatment: gastric lavage, the appointment of salt laxatives; symptomatic therapy.

AntiAngin formula spay Interactions

Sucrose, polysorbate 80, insoluble salts of magnesium, zinc and calcium reduce the effect of chlorhexidine.
Tetracaine reduces the antibacterial activity of sulfanilamide preparations. Vasoconstrictors prolong the effect and reduce toxicity. Drugs that inhibit cholinesterase (antimiasthenic drugs, cyclophosphamide, thiotepa, etc.), reduce the metabolism of tetracaine and increase its toxicity. Anticoagulants (dalteparin sodium, enoxaparin sodium, heparin sodium, warfarin) increase the risk of bleeding. When tetracaine is used with drugs that inhibit MAO (furazolidone, procarbazine, selegiline), the risk of lowering blood pressure increases. Tetracaine enhances and lengthens the effect of myorelaxing drugs. Beta-adrenoblockers slow down the metabolism of tetracaine, increasing its toxicity (decreased hepatic blood flow).

special instructions

The spray should not be inhaled. Avoid contact with the eyes.
If after 3 days after the start of treatment the symptoms of the disease do not disappear or the deterioration of the course of the disease is observed, it is necessary to determine the expediency of its further application.
Children can use Anti-Angin formula spay from the age of 10, while the child should be able to hold his breath when injecting the drug.
When taking the drug must take into account that 1 dose (1 injection) contains 83 mg of absolute ethanol.
It is not recommended to apply simultaneously with drugs for the treatment of the oral cavity and throat, containing iodine (Lugol's solution, povidone-iodine).
Impact on the ability to drive vehicles and manage mechanisms
Anti-Angin formula spay should be taken no later than 30 minutes before the start of driving. If this recommendation is observed, the drug does not affect the ability to drive vehicles and control mechanisms.

Pregnancy and lactemia

Use during pregnancy and lactation is possible only after consulting a doctor.

Application in childhood

Contraindicated for children under 10 years. Children can use the drug from the age of 10, while the child should be able to hold his breath when injecting the drug.

In case of violations of kidney function

With caution in hyperoxaluria, oxalosis and urolithiasis.

Conditions of leave from pharmacies

To buy Anti-Angin formula spay you don't need a prescription.

Terms and conditions of storage

At a temperature of no higher than 25 ° C. Keep out of the reach of children! Shelf life - 2 years.