Bronchobos caps 375mg #30

Instruction for Bronchobos

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Composition

5 ml of the syrup contains 125 mg or 250 mg of active carbocisteine ​​and auxiliary inactive compounds: 135 mg of glycerol, 125 mg of ethanol, 96%, 30.5 or 61 mg of sodium hydroxide, 20 mg of carmellose sodium, 5 or 10 mg of citric acid monohydrate, 9 mg of methyl parahydroxybenzoate, 5 mg of sodium saccharinate, 1 mg of propyl parahydroxybenzoate, 0.7 mg of raspberry flavor, 0.05 mg of azorubin CI14720 (E122), and up to 5 ml of purified water.
One capsule of Bronchobos contains 375.0 mg of active carbocisteine ​​and auxiliary inactive compounds: 23 mg of corn starch, 2 mg of magnesium stearate, 8 mg of gelatin, 2 mg of colloidal silica.

Form of issue

Syrup Bronchobos 2.5% and 5% is a clear, slightly viscous liquid that has the smell of raspberry and the color from pink to bright red. Produced in 200 ml vials of dark brown glass, sealed with aluminum caps, having a sealant, first opening control and a protective mechanism for children. In each cardboard pack there is one vial, a measuring spoon made of polystyrene with labels.
Bronchobos capsules of yellow color, opaque, hard and gelatinous, inside are filled with white powder. In each cardboard bundle there are 3 blisters of PVC / aluminum for 10 caps.

pharmachologic effect

The drug has mucolytic and expectorant effect.

Pharmacodynamics and pharmacokinetics

    The mucolytic and expectorant effect of the syrup is due to activation of the enzyme - sialase transferase, which is produced in cells of goblet form in bronchial mucosa. This normalizes the quantitative ratio of neutral and acidic sialomucins in a bronchial secretion, restores the viscosity and elasticity of the mucus. Promoting the regeneration of the mucous membrane, the structure is normalized and the activity of the ciliary epithelium is activated. Restoring the secretion of immunoglobulin A as a specific defense and the amount of sulfhydryl groups in mucus components as a nonspecific defense qualitatively improve mucociliary clearance.
    Bronchobos tablets have the same pharmacological effects and mechanism of action, and also have a diluting effect on the bronchial secret, which is separated from the paranasal sinuses in the nose, facilitating the passage of phlegm, mucus, reducing cough.

Pharmacokinetics of syrup

Absorption occurs quickly and almost completely with low bioavailability - less than 10% of the dose taken. The maximum level of active carbocisteine ​​in the blood and mucous membranes is reached after 1.5-2 hours, the therapeutic level remains for 8 hours, the longest delay in blood flow, liver, and middle ear. At the highest concentrations, it accumulates in the bronchial secretion - approximately 17.5% of the dose taken. Metabolism occurs in the liver and is characterized by the effect of the first passage through the liver. Excretion - through the kidneys at 60-90% in unchanged form, the rest - metabolites. Half-life is 2-3 hours, and completely occurs - after 3 days.

Pharmacokinetics of the drug in capsules

Bioavailability is also low - no more than 10% of the dose taken. However, the maximum level of active carbocisteine ​​in the blood and mucous membranes is reached after 2-3 hours and is also maintained for 8 hours. Metabolism occurs in the liver and is characterized by the effect of the first passage through the liver. Excretion is mainly through the kidneys in unchanged form and in the form of metabolites. Half-life is approximately 2 hours.

Indications for use

    Bronchobos is prescribed for acute and chronic bronchopulmonary diseases, which are accompanied by a violation of secretion and excretion of mucus, for example, with tracheitis, bronchitis, tracheobronchitis, bronchial asthma, bronchoectatic disease;
    inflammatory processes in the middle ear and paranasal sinuses, including rhinitis, sinusitis and otitis media;
    during the preparation of patients for bronchoscopy or bronchography.

Contraindications

When using any dosage forms
    the presence of hypersensitivity to the components of the drug;
    Stomach ulcer and 12 duodenal ulcer in exacerbation;
    glomerulonephritis chronic in exacerbation, as well as cystitis;
    age group: up to 15 years.
When using syrup 2.5 / 5%
    with various diseases of the liver, as well as alcoholism;
    epilepsy;
    trauma and brain disease;
    special groups of patients: pregnant and lactating women.
When using syrup 2.5%
age group: up to 3 years.
When using capsules
Pregnancy in the first trimester.
General for use with caution
Presence in the anamnesis of a peptic ulcer of a stomach and 12-типерстной a gut.
For use with caution capsules
    presence in the history of chronic glomerulonephritis;
    II and III trimesters of pregnancy, breast-feeding.

Side effects

Undesirable effects can arise from the following systems / bodies:
    GASTROINTESTINAL: sometimes recorded nausea, vomiting, diarrhea and epigastric pain, bleeding.
    Immune system: in isolated cases - allergic reactions in the form of skin itching, hives, exanthema, angioedema.
    Among others: the emergence of weakness, dizziness, malaise.
    In patients with bronchial asthma, as well as elderly patients, airway obstruction can develop.

Instructions for use Bronchobos (Method and dosage)

Syrup Bronchobos, instructions for use
The dosage is determined using a measuring spoon.
    For adults, the dosage is 15 ml, that is 3 measuring spoons of 5% syrup 3 times a day.
    For children 3-6 years - 5 ml, that is 1 measuring spoon - 2,5-percent syrup 2-4 times a day.
    For children from 6 years - 5-10 ml, that is 1-2 measuring spoons 2.5% syrup 3 times a day.
Bronchobos capsules, instruction manual
For adults and adolescents from 15 years, the recommended dose is 750 mg, that is 2 capsules (tablets) 3 times a day. When the therapeutic effect is achieved, the daily dose can be reduced to 2 capsules 2 times a day. The course of treatment should not exceed 8-10 days without the advice of a doctor.

Overdose

Symptomatology
Presence of pain in the stomach, nausea and diarrhea.
Treatment
Treatment should be prescribed symptomatic.

Interaction

All dosage forms
    There is a mutual increase in glucocorticoid efficacy, as well as an individual antibacterial effect in the treatment of infectious and inflammatory processes in the upper and lower respiratory tract.
    Potential bronchodilator effect Theophyllin.
    With atropinopodobnymi means - the antitussive effect is weakened.
Additional when applying syrup
    With caution because of the presence of alcohol used with drugs that cause fever, redness, vomiting, tachycardia.
    With alcoholic beverages, it is recommended to use with caution Cefamandol, Cefoperazone, Disulfiram, Latamoxef, other cephalosporin antibiotics, such a phoenic antibiotic as Chloramphenicol, Glibenclamide, Glipizide, Chlorpropamide, Tolbutamid and other sulfamide antidiabetic agents, Griseofulvin as an antifungal drug, nitro 5-imidazoles, among Metronidazole, Secnidazole, Tinidazole, Ornidazole, and also cytostatics: Ketoconazole, Procarbazine, drugs that depress the central nervous system.

Terms of sale

You can buy Bronchobos without prescription.

Storage conditions

    The temperature range is within the range of 15-30 ° Celsius.
    Keep out of the reach of children.
Shelf life - 3 years.

special instructions

Syrup

The drug contains 125 mg or 5 ml of alcohol, which corresponds to 125 mg of alcohol in 1 measuring spoon.
There is a violation of the speed of psychomotor reactions in connection with the presence of alcohol in the syrup, which is dangerous when driving a car and controlling machine tools.

Reviews about Bronchobos

As a qualitative and effective mucolytic, Bronchobos is able to dilute and excrete sputum from the bronchi. It is possible to use syrup in children from the age of three, since there are few contraindications and side reactions to the drug.