Neo-Bronchol tabs 15mg #20

Instruction for Neo-Bronchol

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Composition

1 tablet for resorption without sugar contains the active substance: 15 mg of ambroxol hydrochloride and auxiliaries: acacia, sorbitol solution 70%, peppermint leaves, oil, eucalyptus leaf oil, sodium saccharinate dihydrate, paraffin liquid, purified water.

Description

Round, convex on one side and concave on the other side tablets with a rough surface of light brown color with a slight minty flavor.
Allowed uneven staining, the presence of air bubbles in the tablet mass, a slight uneven edges.
Pharmacotherapeutic group:
Mucolytic, expectorant.
ATX code: R05CB06

Pharmachologic effect

Mucolytic agent, stimulates prenatal lung development (increases synthesis, secretion of surfactant and blocks its disintegration). Has a secreto-motor, secretolitic and expectorant action; stimulates serous cells of the glands of the mucous membrane of the bronchi, increases the content of mucous secretions and the release of surfactant (surfactant) in the alveoli and bronchi; normalizes the disturbed ratio of serous and mucous components of sputum. By activating hydrolysing enzymes and enhancing the release of lysosomes from Clara cells, reduces the viscosity of sputum. Increases the motor activity of the ciliated epithelium, increases mucociliary transport. After oral administration, the effect occurs 30 minutes later. and lasts for 6-12 hours.

Pharmacokinetics

Absorption is high (for any route of administration), the time to reach the maximum concentration in the blood is 2 hours, the connection with plasma proteins is 85%. Penetrates through the blood-brain barrier, placental barrier, excreted in breast milk. Metabolism - in the liver, forms dibromantranilic acid and glucuronic conjugates. The half-life of T1 / 2 is 7-12 hours. It is excreted by the kidneys: 90% in the form of water-soluble metabolites, in unchanged form - 10%. T1 / 2 increases by 20-40% in severe chronic renal failure (CRF), does not change when the liver function is impaired.

Indications for use

Diseases of the respiratory tract, accompanied by the release of viscous and difficult secretion: acute and chronic bronchitis, pneumonia, COPD (chronic obstructive pulmonary disease), bronchial asthma with difficulty in sputum discharge, bronchiectatic disease.

Contraindications for Neo-Bronchol

Hypersensitivity.
Pregnancy: 1 trimester.
Children under 6 years.

Carefully

hepatic failure, renal dysfunction, peptic ulcer and duodenal ulcer, pregnancy (II - III trimester), lactation.
In the case of rare bronchial diseases associated with excessive sputum production, Neo-Bronchol should be used with extreme caution, under the supervision of a physician.

Dosing and Administration

Tablets for resorption without sugar
Children from 6 to 12 years:
To dissolve one tablet (15 mg) 2-3 times a day. Do not take more than 3 tablets for resorption within 24 hours (corresponding to 45 mg of ambroxol hydrochloride).
Adults and children over 12 years of age:
To dissolve two tablets (30 mg) 3 times a day for the first 2-3 days. Do not take more than 6 tablets within 24 hours. Further it is recommended to take 1 tablet 3 times a day.
Tablets should be taken after meals and rassasyvat until complete dissolution.
To achieve a greater mucolytic effect, during the therapy it is necessary to consume a sufficient amount of liquid.
Do not take Neo-Bronchol for more than 4-5 days without specifying a doctor.
Indication for patients with diabetes:
1 tablet for resorption without sugar Neo-Bronchol contains 70% solution of sorbitol (not crystallized), 922.2 mg (dry matter), which corresponds to 0.08 XE (bread units).

Side effects of Neo-Bronchol

From the gastrointestinal tract: rarely - nausea, diarrhea, constipation, gastralgia, vomiting.
Allergic reactions: skin rash, itching, hives, contact dermatitis, in isolated cases - anaphylactic shock, angioedema, exanthema.
On the part of the respiratory system: dryness in the respiratory tract
From the urinary system: dysuria.
Other: weakness, headache, rhinorrhea.
If side effects occur, stop taking the medication and consult a doctor.

Overdose

Symptoms: nausea, vomiting, diarrhea, indigestion.
Treatment: artificial vomiting, gastric lavage in the first 1-2 hours after taking Neo-Bronchol, taking fat-containing foods.

Interaction with other drugs

Joint use with antitussive drugs leads to difficulty in sputum discharge against the background of a reduction in cough. Increases the penetration into the bronchial secret of antibiotics amoxicillin, cefuroxime, erythromycin, doxycycline.

Form of issue

Tablets for resorption without sugar 15 mg. For 10 tablets in a blister of PVC (polyvinyl chloride) film and aluminum foil; for 2.3 or 4 blisters together with instructions for use in a cardboard box.

Storage conditions

At a temperature not higher than + 25 ° C, in a place protected from light.
Keep out of the reach of children.
Shelf life - 4 years. Do not use Neo-Bronchol with expired shelf life.

Vacation from pharmacies

To buy Neo-Bronchol the prescription is not needed.