Pentaflucin day granules 5gr #10

Pentaflucin day instruction for use

You can buy Pentaflucin day here

Description:
A mixture of granules of different shapes and sizes: round, cylindrical or irregular in shape; white, white with a yellowish tinge and a yellow-green color.

Composition

1 sachet (5 g) contains:
Active substances:
ascorbic acid 0.2 g
calcium gluconate monohydrate 0.2 g
caffeine (in terms of monohydrate) - 0.02 g
paracetamol 0.5 g
rutoside trihydrate - 0.02 g
Excipients:
Povidone (polyvinylpyrrolidone) 0.0174 g sucrose (sugar) 3.9426 g saccharin (saccharin soluble) 0.050 g citric acid 0.050 g
Pharmacological group
ORZ and "colds" of symptoms remedy
ATX code: [R05X]

Pharmacological properties

Pentaflucin day cream is a combined medicine.
Pharmacological effects are due to the complex effects of the components that make up Pentaflucin day.
Paracetamol - has antipyretic and analgesic effect, blocks the enzyme of cyclooxygenase type 1 (COX-1) and enzyme cyclooxygenase type 2 (COX-2), mainly in the central nervous system, affecting the centers of pain and thermoregulation.
Ascorbic acid plays an important role in the regulation of oxidation-reduction processes, carbohydrate metabolism, blood coagulability, tissue regeneration, and increases the body's resistance.
Caffeine - has psychostimulant (stimulates the psychomotor centers of the brain), an analeptic effect, increases the analgesic effect of paracetamol eliminates drowsiness and a sense of fatigue, increases physical and mental performance.
Calcium gluconate is a source of calcium in the body, has an antiallergic effect (the mechanism is unclear), prevents the development of increased permeability - and fragility of the vessels that cause hemorrhagic processes in influenza and acute respiratory viral infection, and restores capillary circulation.
Rutozid - reduces permeability and fragility of capillaries, has antioxidant properties.

Indications for use

Pentaflucin day cream is used in adults for the symptomatic treatment of acute respiratory infections (ARI) and acute respiratory viral infections (ARVI), accompanied by fever, chills, headache and muscle pain.

Contraindications for Pentaflucin day

    Hypersensitivity to the components of Pentaflucin day.
    Pronounced impairment of liver or kidney function.
    Diseases of the blood with a tendency to hemorrhage.
    Deficiency of glucose-6-phosphate dehydrogenase.
    Children's age (up to 18 years).
    Congenital intolerance to fructose, glucose-galactose malabsorption, sucrose-isomaltase deficiency.

Carefully

With Gilbert syndrome (constitutional hyperbilirubinemia). The composition of Pentaflucin day includes sugar (1 packet contains 0.33 XE of sugar), which should be taken into account by a patient with diabetes mellitus.

Application in pregnancy and during breastfeeding

The use of Pentaflucin day during pregnancy and during breastfeeding is contraindicated. If it is necessary to use Pentaflucin day during lactation, stop breastfeeding for the entire treatment period

Dosing and Administration

Pentaflucin day cream is used inside after eating 1 packet 3-4 times a day for 3-5 days.
The contents of one sachet of the preparation should be dissolved in 1/2 cup (125 ml) of hot water (t = 70 ° C) and drunk. Allowed a slight deposit in the glass. Use a freshly prepared solution. Shake before use.

Side effects of Pentaflucin day

In the recommended dosage, adverse reactions are rare. Sometimes there may be skin allergic reactions, nausea, vomiting, headache, general weakness, dizziness.
Ascorbic acid:
From the side of the urinary system: moderate pollakiuria (when taking a dose of more than 600 mg / day), with prolonged use of large doses of -tiperoxaluria, nephrolithiasis (from calcium oxalate), damage to the glomerular apparatus of the kidneys.
From the digestive system: irritation of the mucous membrane of the gastrointestinal tract.
Allergic reactions: skin rash, skin hyperemia.
Other: oppression of the insular pancreas function (hyperglycemia, glucosuria).
Calcium gluconate:
From the digestive system: constipation, irritation of the mucous membrane of the gastrointestinal tract.
Caffeine:
From the side of the nervous system: agitation, anxiety, tremor, anxiety, headache, dizziness, increased reflexes, tachypnea, insomnia. From the cardiovascular system: palpitation, tachycardia, arrhythmias, increased blood pressure.
From the digestive system: nausea, vomiting, exacerbation of peptic ulcer.
Paracetamol:
From the digestive system: nausea, pain in epigastrium.
From the hemopoietic system: anemia, thrombocytopenia, methemoglobinemia.
Allergic reactions: skin rash, itching, hives, angioedema.
With prolonged use in high doses, hepatotoxic and nephrotoxic effects are possible.
Rutozide:
Allergic reactions: skin rash
From the digestive system: nausea, diarrhea, heartburn.
From the nervous system: headache.
From the side of the cardiovascular system: "tides" of blood to the face.
If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Symptoms (due to paracetamol): during the first 24 hours after administration - pallor of the skin, nausea, vomiting, anorexia, abdominal pain; disturbance of glucose metabolism, metabolic acidosis. Symptoms of liver dysfunction may appear 12-48 hours after an overdose. In severe overdose - liver failure with progressive encephalopathy, coma, death; acute renal failure with tubular necrosis (including in the absence of severe liver damage); arrhythmia, pancreatitis.
Hepatotoxic effect in adults is manifested when taking 10 g or more.
Treatment: the affected person should rinse the stomach, prescribe t adsorbents (activated charcoal) and consult a doctor.
Symptomatic therapy: introduction of donors of SH-groups and precursors of glutathione-methionine synthesis within 8-9 hours after overdose and acetylcysteine ​​for 8 hours. The need for additional therapeutic measures (further introduction of methionine, intravenous acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after its administration.

Interactions Pentaflucin day with other medications

Avoid combination of the drug with barbiturates, anticonvulsants, phenytoin, carbamazepine, rifampicin, zidovudine and other inducers of microsomal liver enzymes.
Paracetamol: reduces the effectiveness of uricosuric medicines. The concomitant use of paracetamol in high doses increases the effect of anticoagulant drugs (a decrease in the synthesis of procoagulant factors in the liver).
Ethanol promotes the development of acute pancreatitis.
Long-term sharing of paracetamol and other non-steroidal anti-inflammatory drugs increases the risk of developing "analgesic" nephropathy and renal papillary necrosis, the onset of the terminal stage of renal failure.
Diflunisal increases the plasma concentration of paracetamol by 50% - the risk of developing hepatotoxicity.
Myelotoxic drugs increase the manifestation of hematotoxicity of Pentaflucin day.
Caffeine: with the joint use of caffeine with cimetidine, oral contraceptives, ciprofloxacin, norfloxacin - a decrease in the metabolism of caffeine in the liver (slowing its elimination and increase in blood concentrations). Mexiletine - reduces caffeine withdrawal to 50%; nicotine-increases the caffeine removal rate.
Inhibitors of monoamine oxidase, furazolidone, procarbazine and selegiline - large doses of caffeine can cause the development of dangerous cardiac arrhythmias or a marked increase in blood pressure.
Accelerates absorption and enhances the action of cardiac glycosides, increases their toxicity.
Joint use of caffeine with beta-blockers can lead to mutual suppression of therapeutic effects; with adrenergic bronchodilator drugs - to additional stimulation of the central nervous system and other additive toxic effects.
Caffeine can reduce the clearance of theophylline and, possibly, other xanthines, increasing the possibility of additive pharmacodynamic and toxic effects.
Ascorbic acid: increases the concentration of benzylpenicillin and tetracyclines in the blood.
At a dose of 1 g / day increases the bioavailability of ethinyl estradiol (including those included in oral contraceptives).
Reduces the effectiveness of heparin and indirect anticoagulants. Improves absorption in the intestine of iron preparations (converts trivalent iron into bivalent); can increase the excretion of iron with simultaneous use with deferoxamine.
Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drink reduce the absorption and absorption of ascorbic acid. '
With simultaneous application with ASA, urinary excretion of ascorbic acid increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by about 30%.
Increases the risk of developing crystalluria in the treatment of salicylates and sulfonamides short-acting, slows the excretion of kidney acids, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood.
With simultaneous use reduces the chronotropic effect of isoprenaline.
Calcium gluconate: when used concomitantly with quinidine, intraventricular conduction may be slowed and quinidine toxicity may be increased.
Forms insoluble complexes with antibiotics of the tetracycline series (reduces the antibacterial effect).
Slows the absorption of tetracyclines, digoxin, oral iron preparations (the interval between their methods should be at least 2 hours).
When combined with thiazide diuretics can increase hypercalcemia, reduce the effect of calcitonin in hypercalcemia. Reduces the bioavailability of phenytoin.
Pharmaceutically incompatible with carbonates, salicylates, sulfates (forms insoluble or hardly soluble calcium salts).,
Reduces the effect of blockers of "slow" calcium channels.
Rutozide: the pharmacological effect is enhanced by ascorbic acid.

special instructions

To avoid toxic damage to the liver, do not combine the drug with alcohol.
During the treatment period, care must be taken when driving vehicles and engaging in potentially dangerous activities that require a high concentration of attention and speed of psychomotor reactions.

Form of issue

Granules for solution for oral administration
5 grams of granules in a bag of paper with a polymer coating.
For 5, 10 bags together with instructions for medical use put in a pack of cardboard.

Storage conditions

In dry, dark place at a temperature of no higher than 25 ° C.
Keep out of the reach of children.
Shelf life - 2 years. Do not use after expiry date.

Conditions of leave from pharmacies

You can buy Pentaflucin day without a prescription.