Motrin tabs 250mg #20

Motrin user manual

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Indications for use

Pain syndrome of mild and moderate severity: neuralgia, ossalgia, myalgia, lumboschialgia, posttraumatic pain syndrome (distension and bruises), accompanied by inflammation, postoperative pain (in traumatology, orthopedics, gynecology, maxillofacial surgery), headache, migraine, algodismenorea, adnexitis, toothache.
Symptomatic therapy of pain syndrome in diseases of the musculoskeletal system, including bursitis, tendovaginitis.
In the complex therapy of infectious and inflammatory diseases of the ear, throat, nose with severe pain syndrome (pharyngitis, tonsillitis, otitis).

Feverish conditions for flu and colds

Motrin is used for symptomatic therapy (to reduce pain, inflammation and decrease in fever) and does not affect the progression of the underlying disease.

Active substance, group

Naproxen, NSAIDs

Dosage form

tablets 250 mg.
For 10 tablets in a planar cell package.
1, 2 or 3 contour mesh packages together with instructions for use in a cardboard bundle.

Contraindications

Hypersensitivity to naproxen or naproxen sodium; complete or partial combination of asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid and other non-steroidal anti-inflammatory drugs (including history). The use of Motrin is also contraindicated during coronary artery bypass grafting.
Erosive-ulcerative lesions of the stomach and duodenum in the phase of exacerbation (ulcerative colitis (YAC), Crohn's disease).
Cerebrovascular bleeding or other bleeding and hemostasis disorders.
Severe renal insufficiency (creatinine clearance less than 30 ml / min), including confirmed hyperkalemia, progressive kidney disease.
Inhibition of bone marrow hematopoiesis. Pregnancy, the period of breastfeeding.
Children under 12 years of age are an obstacle to the use of Motrin.
Caution Motrin can be used in the following conditions and conditions.
Ischemic heart disease, cerebrovascular disease, congestive heart failure, dyslipidemia / hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, creatinine clearance - 30-60 ml / min, medical history data about the development of ulcerative lesions of the gastrointestinal tract, the presence of Helicobacter pylori infection, old age, long-term use of non-steroidal anti-inflammatory drugs, frequent alcohol use, severe somatic diseases, concomitant therapy with the following drugs: ant coagulants (e.g., warfarin), antiplatelet agents (aspirin, clopidogrel), oral corticosteroids (e.g., prednisone), selective serotonin reuptake inhibitor (citalopram, fluoxetine, paroxetine, sertraline). To reduce the risk of developing adverse events from the gastrointestinal tract, the minimum effective dose of Motrin should be taken as the lowest possible course. Children from 12 to 16 years of age admit treatment with Motrin with caution.

Dosing and Administration (Instruction)

Inside, adults and children over 12 years. Motrin tablets should be taken whole, squeezed with enough liquid, can be taken while eating.
To ease the pain, the initial dose is 500 mg, then, if necessary, 500 mg every 12 hours or 250 mg every 8 hours.
The usual daily dose used to relieve pain is 500 to 1000 mg.
To remove the pain syndrome with migraine, a dose of 500 mg twice a day is recommended. However, treatment should be discontinued if the frequency, intensity and duration of migraine attacks do not decrease within 4-6 weeks.
To facilitate menstrual pain, pain after intrauterine administration and other gynecological pain (adnexitis) starting dose is 500 mg, and then, if necessary, at 250 mg every 6-8 hours for 3-4 days.
For the symptomatic treatment of pain in diseases of the musculoskeletal system (bursitis, tenosynovitis), the usual daily dose of 500-1000 mg, in one or two tablets twice a day, morning and evening.
When using Motrin as an antipyretic agent, the initial dose is 500 mg, then, if necessary, 250 mg every 8 hours. Motrin is not recommended for use as an anesthetic for more than 5 days without consulting your doctor. If symptoms persist, consult a physician.

Pharmachologic effect

Motrin is a non-steroidal anti-inflammatory drug (NSAID), has an anti-inflammatory, analgesic and antipyretic effect associated with a non-selective inhibition of cyclooxygenase 1 and cyclooxygenase 2 regulating the synthesis of prostaglandins.
Absorption Motrin from the gastrointestinal tract - fast and complete, bioavailability - 95% (eating practically does not affect either the completeness or the rate of absorption). The time to reach the maximum concentration (TCmax) is 2 hours, the connection with plasma proteins is 99%, the half-life (T1 / 2) is 12-15 hours. Metabolism is in the liver to dimethylnaproxen with the participation of the CYP2C9 enzyme system. Clearance - 0.13 ml / min / kg. It is excreted 98% by the kidneys, 10% of them are excreted unchanged; with bile - 0,5-2,5%. The equilibrium concentration of Motrin ® in the blood plasma (Css) is determined after 2-3 days. With chronic renal failure, cumulation of metabolites is possible.

Side effects

Side effects are most common when using high doses of Motrin.
On the part of the digestive system: constipation, abdominal pain, dyspepsia, nausea, diarrhea, ulcerative stomatitis, erosive and ulcerative lesions and bleeding of the gastrointestinal tract, NSAID-gastropathy (lesion of the antral part of the stomach in the form of erythema of the mucosa, hemorrhages, erosions and ulcers ), increased activity of 'liver' enzymes, impaired liver function, jaundice, bloody vomiting, melena.
From the side of the central nervous system: hearing loss, dizziness, headache, drowsiness, depression, sleep disorders, inability to concentrate, insomnia, malaise, slowing of the speed of psychomotor reactions, aseptic meningitis, cognitive dysfunction.
From the skin: itching, ecchymosis, increased sweating, purpura, alopecia, photodermatosis.
From the senses: tinnitus, visual impairment, hearing impairment;
From the side of the cardiovascular system: swelling of the face, limbs, shortness of breath, palpitations, occurrence or aggravation of existing chronic heart failure, vasculitis.
On the part of the genitourinary system: glomerulonephritis, hematuria, interstitial nephritis, nephrotic syndrome, renal failure, renal papillary necrosis, menstrual irregularities.
From the hemopoietic organs: eosinophilia, granulocytopenia, leukopenia, thrombocytopenia, aplastic anemia, hemolytic anemia.
From the respiratory system: eosinophilic pneumonitis.
Allergic reactions: skin rash, hives, angioedema, toxic epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome.
Other possible side effects of Motrin: thirst, hyperthermia, hyperglycemia, hypoglycemia, myalgia and muscle weakness.

Special instructions

Do not exceed the dosage indicated in the instructions contained in the Motrin package. To reduce the risk of developing adverse events from the gastrointestinal tract, use the minimum effective dose as short a course as possible. If pain and fever persists or worsens, you should consult your doctor.
Patients with bronchial asthma, with blood clotting disorders, and also patients with hypersensitivity to other analgesics before taking naproxen should consult a doctor.
Caution should be given to patients with liver disease and kidney failure. In patients with renal insufficiency, it is necessary to control the clearance of creatinine. In chronic alcoholic and other forms of cirrhosis of the liver, the concentration of unbound naproxen increases, therefore, such patients are recommended to have lower doses.
Motrin (naproxen) should not be taken with other anti-inflammatory and analgesic medications, except for prescribing a physician. Older patients are also recommended lower doses. You should avoid taking naproxen within 48 hours before surgery. If it is necessary to determine 17-corticosteroids, the drug should be discontinued 48 hours before the test. Similarly, naproxen may affect the determination of 5-hydroxyindoleacetic acid in the urine. The use of naproxen, as well as other drugs blocking the synthesis of prostaglandins, can affect fertility, so it is not recommended for women planning a pregnancy.

Interaction

When treating anticoagulants, it should be borne in mind that Motrin (naproxen) may increase bleeding time. Do not use the drug simultaneously with other non-steroidal anti-inflammatory drugs (increased risk of side effects).
With the simultaneous use of hydantoin derivatives, anticoagulants or other drugs that bind to a large extent with plasma proteins, the effect of these drugs may be potentiated.
Naproxen can reduce the antihypertensive effect of propranolol and other beta-blockers, and may also increase the risk of renal failure associated with the use of ACE inhibitors.
Under the action of naproxenum, natriuretic action of furosemide is inhibited.
Inhibition of renal clearance of lithium leads to an increase in the concentration of lithium in the plasma.
The use of probenecid increases the level of naproxen in plasma.
Cyclosporine increases the risk of developing kidney failure.
Naproxen slows the excretion of methotrexate, phenytoin, sulfonamides, increasing the risk of developing their toxic effects.
Antacid preparations containing magnesium and aluminum reduce the absorption of Motrin (naproxen).

Storage conditions

In dry, the dark place at a temperature of no higher than 25 ° C.
Keep out of the reach of children.
Shelf life - 3 years. Do not use after the expiration date.

Leave conditions

To buy Motrin you don't need a prescription.