Sedalgin Plus #20

Sedalgin Plus instruction manual

You can buy Sedalgin Plus here

Composition Sedalgin Plus

The tablet contains 500 mg of metamizole Na, 50 mg of caffeine and 38.75 mg of thiamine hydrochloride. Sedalgin Plus contains additional components: colloidal silicon dioxide 2.5 mg, wheat starch 11 mg, microcrystalline cellulose 45.75 mg, talc 12 mg, gelatin 4 mg, stearate Mg 6 mg.

Form of issue

Sedalgin plus is available in tablet form. Flat, round tablets of white color with a bilateral facet are packed in blisters of 10 pieces. Each cardboard pack has 1 or 2 blisters.

pharmachologic effect

The drug has anti-inflammatory, analgesic and anti-pyretic action.
Metamizole Na has a mild anti-inflammatory effect, has analgesic effect. The mechanism of action is based on the ability of the pyrazolone derivative to inhibit the synthesis of prostaglandins through inhibition of cyclooxygenase.
Caffeine has a stimulating effect on the nervous system, activating the vasomotor center, the cerebral cortex and the respiratory center. The active component reduces the severity of fatigue and drowsiness, increases physical and mental performance. Caffeine enhances the therapeutic effect of non-narcotic analgesics, increasing their bioavailability and increasing the permeability of histohematological barriers.
Thiamine has a charitable effect on the neuro-reflex conductivity, improves metabolism. It is also known as vitamin B1.

Pharmacodynamics and pharmacokinetics

The indicators depend on the components that make up the medication.
Metamizole Na is completely absorbed from the digestive tract in a fairly short period of time. The maximum concentration is recorded 1-1.5 hours after admission. The active component binds to plasma proteins, but is metabolized in the hepatic system. With bile, 10% of metabolites are excreted, 90% through the renal system. The half-life is approximately 10 hours.
Caffeine is almost completely absorbed from the digestive tract. The maximum level of the active component is observed after 30-40 minutes. Caffeine is able to penetrate into breast milk, pass through the blood-brain barrier. Metabolites are excreted unchanged through the renal system.
Thiamine, after ingestion, absorbs high digits and is carried out in the lumen of the small intestine. Digestive enzymes release thiamine hydrochloride from the bound state before absorption. The level of thiamine in the blood is low enough. In the plasma, only free thiamine can be found, and its phosphoric esters are found in blood cells: leukocytes and erythrocytes. 40% of thiamine can be found in the internal organs, and more than 50% - in the striated muscle. The process of phosphorylation is carried out in the liver tissue. Thiamindiphosphate has coenzyme activity and is the most active phosphoric ester. It accumulates in the kidneys, heart muscle, liver tissue, spleen, brain. It is excreted through the renal system, part - through the intestine.

Indications for use

What is Sedalgin Plus appointed from? Basically for relief of pain syndrome with:
    dysmenorrhea;
    neuralgia;
    migraine;
    polyneuropathy;
    plexite;
    inflammatory diseases of the musculoskeletal system;
    degenerative pathology of muscle tissue;
    toothache;
    root syndrome;
    after surgical interventions.

Contraindications

    thrombocytopenia;
    anemia;
    leukopenia;
    individual hypersensitivity;
    pronounced atherosclerotic changes;
    hepatic porphyria;
    breast-feeding;
    suspected acute surgical pathology;
    intolerance to NSAIDs;
    ulcerative pathology of the gastrointestinal tract;
    sleep disorders;
    bearing pregnancy;
    pathological excitability;
    pathology of the hepatic system;
    bronchial asthma;
    glaucoma;
    simultaneous treatment with MAO inhibitors;
    hypertonic disease;
    kidney disease.

With care, the combination is prescribed for:

    akhalasia;
    IHD;
    arrhythmias;
    stenosis of the pyloric part of the digestive system;
    hyperplastic changes in the prostate tissue;
    bronchospastic reactions;
    hyperthyroidism;
    heart failure (stagnation);
    the use of drugs that depress the work of the nervous system;
    gastroesophageal reflux.

Side effects

The system of hematopoiesis:

    purpura;
    leukopenia;
    thrombocytopenia (decrease in the number of platelets);
    hemolytic form of anemia;
    agranulocytosis.

The digestive tract:

    jaundice;
    vomiting;
    a violation of appetite;
    cholestasis;
    nausea.

Nervous system:

    increased excitability;
    dizziness;
    insomnia.

The cardiovascular system:

    rhythm disturbances;
    a feeling of rapid heartbeat.

Allergic Answers:

    redness;
    itching;
    anaphylactic shock;
    edema of Quincke;
    bronchospasm.
At occurrence of other negative reactions the patient should address to the doctor, having ceased to accept Sedalgin Plus.

Instructions for use (Method and dosage)

The medication is taken internally. The tablet should be washed down with water. With a painful syndrome, one tablet is prescribed three times a day. If the inefficiency of the number of tablets can be increased to 6 pieces per day. In pediatric practice, appoint ½ tablet three times a day, but not more than 4 pieces.

Overdose

It appears rashes on the skin. Less common is tremor of limbs, anaphylactic shock, hallucinations, a clinical picture similar to Meniere's disease. A significant excess of recommended dosages can lead to loss of consciousness, serious changes in the heart, nervous system, blood. It requires cleansing of the stomach and intestines from the remnants of the medication, the appointment of sorbents, and the conduct of post-syndrome treatment. Specific antidote for Sedalgin Plus is not developed. When diagnosing hemorrhagic gastritis, gastric lavage is performed with a cold solution of NA chloride (0.9%) and antacids are administered. If necessary, oxygenation is carried out, ventilation of the lungs is maintained. In epileptic seizures, phenytoin is administered, diazepam intravenously. It is important to maintain the level of liquids and salts at the required level.

Interaction

Metamizole sodium can increase the toxic effect of other medicines. Medications that increase the toxicity of Sedalgin Plus and interfere with the metabolism of its components:
    Allopurinol;
    antidepressants (tricyclic);
    contraceptive means in oral form.
Inducers of microsomal enzymes (Butadion, barbiturates) weaken the action of the drug. Metamizole sodium is able to reduce the level of Ciclosporin in the blood. Analgesic effect Sedalgin Plus increases with the use of tranquilizers and other sedatives.

Terms of sale

OTC medicines.

Storage conditions

The manufacturer limits the temperature regime of storage - up to 25 degrees. Limit children's access to blisters.

Shelf life

2 years.

special instructions

Symptoms of overdose may also be manifested when the patient consumes foods high in caffeine (coffee, tea). For kidney diseases and the liver system, an additional examination is recommended. The risk of developing an allergic response is higher in patients suffering from pollinosis, bronchial asthma (atopic form). It is inadmissible to take alcoholic drinks at the same time as taking the medication.

Reviews of Sedalgin Plus

Doctors quite often prescribe medication as part of analgesic therapy. At the forums patients leave their feedback about Sedalgin Plus, indicating a good tolerability of tablets and high effectiveness in stopping the pain syndrome.