Versatis #5

Versatis instruction

You can buy Versatis here

Composition

In one patch, 13.3-14.7 cm long, 9.5-10.5 cm wide, there are 700 mg of active lidocaine and such inactive auxiliary compounds: 3367 mg of purified water, 2,520 mg of glycerol; 2800 mg of sorbitol, 1400 mg of polyacrylic acid solution 20%, 700 mg of sodium polyacrylate, 700 mg of carmellose sodium, 700 mg of propylene glycol, 420 mg of urea, 210 mg of kaolin, 210 mg of tartaric acid, 147 mg of gelatin, 58.8 mg polyvinyl alcohol (75,000), 32.2 mg of aluminum dihydroxyaminoacetate (aluminum glycinate), 14 mg of disodium edetate, 14 mg of methyl parahydroxybenzoate, 7 mg of propyl parahydroxybenzoate, 1750 mg of non-woven fabric and 742 mg of plastic film (polyethylene terephthalate, PET).

Form of issue

The patch is white or bright yellow, is made of a polymer adhesive adhesive material, covered with a plastic film, has a weak characteristic odor. On the non-woven fabric there is an embossing "Lidocaine 5%".
Plaster Versatis for local use packed in sachets of 5 pcs. In a cardboard bundle there may be 1, 2, 6 sachets.

pharmachologic effect

It has a local anesthetic effect.

Pharmacodynamics and pharmacokinetics

Versatis has a local anesthetic - lidocaine, which is an acetamide derivative that has membrane-stabilizing activity and the ability to block sodium channels in excitable neuronal membranes. With local use on skin that does not have damage, the expected therapeutic effect arises - removal of the pain syndrome, without systemic influence.

Data on pharmacokinetics

Approximately 3 ± 2% of lidocaine is adsorbed from the total amount contained in the patch. Achieving maximum blood concentrations of 0.13 μg / ml is possible with the addition of 3 patches for 12 hours. Binding to plasma proteins occurs on 50-80%.
Distribution fast (the half-life of the distribution phase lasts 6-9 minutes) begins with penetration into well-provided blood supply tissues, then into adipose and muscle tissue.
Lidocaine is able to penetrate the blood-brain and placental barriers, excreted together with breast milk (approximately 40% of the concentration in the blood plasma of a woman). Metabolism occurs in the liver by 90-95%, taking into account the action of microsomal enzymes before the formation of pharmacologically active metabolites. Excretion through the kidneys and with bile, and up to 10% is eliminated unchanged.
Peculiarities of pharmacokinetics in special groups of patients
    In individuals with liver disease, the metabolic rate decreases to 10-50% of the normal value.
    With chronic renal failure - the accumulation of metabolites, while acidification of urine causes an increase in the excretion of lidocaine.

Indications for use

    pain syndrome, incl. vertebrogenic;
    inflammatory processes in skeletal muscles of various genesis - myositis;
    postherpetic neuralgia.

Contraindications

Plaster with lidocaine Versatis is contraindicated:
    at violations of the integrity of the skin of the site of application;
    with established hypersensitivity to lidocaine and other components of the plaster;
    pregnant and breast-feeding mothers.
Caution should be applied
    with infectious or traumatic skin lesions in the presumed place of application;
    in acute phases of disease or in weakened patients;
    during therapy with antiarrhythmic drugs of the first class and other local anesthetics;
    in pediatrics;
    in elderly persons.

Side effects

From the side of the immune system, it is possible to develop allergic contact dermatitis, which manifests itself as hyperemia at the site of application, skin rash, urticaria, pruritus, and there were burning cases of the skin area exposed to the drug. Cases of angioedema development have also been reported.
Versatis, Instructions for Use (Method and Dosage)

Dosage

The patch is glued to intact, non-inflamed dry skin in the area of ​​the onset of pain syndrome - 1 time per day for 12 hours maximum. It is possible to use no more than 3 patches simultaneously. If the plastic protective film has not been removed, then the patch can be cut into the required number of parts. Duration of treatment up to 2-4 weeks, if the therapeutic effect is insufficient or is provided only by its protective properties, the treatment is terminated.

Features of the patch application

The patch is applied externally, it should be glued to the skin immediately after it is removed from the sachet and the plastic film is removed from the sticky layer. Hair is recommended to shear with scissors, but do not shave!
Attention! After gluing the patch, you should immediately wash your hands. Avoid contact with the eyes!

Recycling

Do not apply the used adhesive again. Since it contains the active substance, it must be disposed of immediately after removal, fold the adhesive in half an adhesive side inward and make sure that it is not accessible to children and pets.

Overdose

Receiving over doses of the drug Versatis is unlikely, but it is not completely excluded, because with improper use it is possible to achieve higher plasma concentrations, which differ from the established norms for the therapeutic effect. Possible manifestation of systemic toxicity similar to that after administration of lidocaine as a local anesthetic. It is accompanied by the following symptoms:
    anaphylaxis;
    convulsions;
    tremor;
    depression;
    euphoria;
    excitation of the central nervous system;
    headache;
    dizziness;
    a feeling of fear;
    anxiety;
    visual impairment;
    noise in the ears;
    bradycardia;
    hypertension;
    sensation of heat or cold;
    respiratory depression.

Actions taken in case of an overdose

Antidote specific to lidocaine does not exist. If suspicious symptoms are found - the bandage should be immediately removed, disposed of and contacted by a doctor.

Interaction

Versatis has very low plasma concentrations of lidocaine, so clinically meaningful drug interactions are unlikely.

Terms of sale

To buy Versatis you don't need a prescription.

Storage conditions

Versatis should be stored at a temperature of up to +25 ° Celsius, without undergoing freezing. After opening the package, the sachet should be tightly closed. For security reasons, it is desirable to completely restrict access to minors.
Shelf life - 36 months. Once opened, the patches can be used for 2 weeks.

Reviews of Versatis

Patients who used Versatis, argue that the drug is very helpful. Positive review was given to plaster in people suffering from myositis, scoliosis, sharp pains in the neck and back. They say that this is a good prevention and real help, so that the pain subsides and does not return.