Seretide aerosol 25mcg/250mcg 120doses
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Seretide user manualYou can buy Seretide hereComposition(INN): Salmeterol + FluticasoneIn the drug Seretide Evohaler contains salmeterol (form of salmeterol xinafoate), fluticasone propionate, as well as additional substances.The ..
Seretide user manual
You can buy Seretide here
(INN): Salmeterol + Fluticasone
In the drug Seretide Evohaler contains salmeterol (form of salmeterol xinafoate), fluticasone propionate, as well as additional substances.
The preparation Seretide Diskus contains salmeterol (form of salmeterol xinafoate), micronized fluticasone propionate, as well as additional substances.
The Seretide Multidisk powder contains salmeterol (xinafoate form), fluticasone propionate and additional substances.
Form of issue
Aerosol Seretide Evohaler can be accommodated in an aluminum aerosol can which contains 120 doses of the drug. The cylinder is equipped with a metering valve. A balloon, a protective cap and a plastic dispenser are contained in a pack of cardboard.
Dosage powder Seretide Diskus for inhalation is contained in a cell blister pack of foil (60 doses of the drug). Each cell contains one dose of the drug. The cardboard pack contains a plastic device for inhalation and one blister pack.
Seretide Multidisk is a powder for carrying out inhalations of white color or an off-white shade. The cardboard pack contains a round plastic inhaler with a dose counter. One package may contain 28 or 60 doses of the drug.
Seretide Evohaler, Seretide Diskus, Seretide Multidisk - combined medicines with anti-asthmatic effect. They contain fluticasone propionate and salmeterol.
Salmeterol is a selective beta2-adrenergic receptor agonist. It has a long action, which lasts no less than 12 hours. Under the influence of salmeterol relax smooth muscles of the bronchi, the development of bronchospasm is prevented.
Fluticasone propionate is part of the group of glucocorticosteroids. Fluticasone propionate provides an anti-inflammatory effect. It reduces the frequency, severity of attacks of bronchial asthma. When fluticasone propionate is used, those unwanted effects that often occur when using systemic corticosteroids do not develop.
In the combination of fluticasone and salmeterol, the pharmacokinetics of these substances are similar to their action in a separate application.
When using Seretide Diskus provides control over the manifestation of asthma symptoms and has a more effective effect than monotherapy with glucocorticosteroids. When combined treatment with salmeterol and fluticasone is used, exacerbations appear 29% less frequently than with monotherapy with glucocorticosteroids. With the treatment, the drug reduces the need for using rapid bronchodilators, reduces the frequency of exacerbations of asthma and there is an overall improvement in the quality of life in people with asthma.
Pharmacodynamics and pharmacokinetics
Salmeterol has a local effect on lung tissue. When carrying out inhalation, the concentration in the plasma is low. After repeated inhalations in the blood, hydroxyanaphthoic acid is detected in small concentrations.
Fluticasone propionate has a bioavailability in a healthy person of 10-30% of the dose, depending on which inhaler is used.
People who suffer from bronchial asthma and COPD have a lower plasma concentration of fluticasone propionate. The drug is predominantly absorbed in the lungs, initially there is more active adsorption, later it slows down.
Part of the dose used for inhalation, a person can swallow, but its effect on the body is minimal, since fluticasone propionate is poorly soluble in water. When sucking fluticasone propionate from the digestive tract, its bioavailability is less than 1%.
In the course of increasing doses for inhalation, an increase in the plasma concentration of fluticasone propionate was noted. There is a high degree of binding with blood proteins of fluticasone propionate - 91%. Fluticasone propionate is actively excreted from the blood mainly due to metabolism. The half-life is about 8 hours. With urine in the form of a metabolite, less than 5% of the dose obtained is excreted. Through the intestine is derived mainly as a hydroxylated metabolite.
Salmeterol almost does not enter the bloodstream when used as an inhalation. The substance is not cumulated in the body, after 1 year after the initiation of therapy, the plasma level of salmeterol is not increased.
Indications for use
Medication Seretide Evohaler is used for regular therapy of bronchial asthma in cases when it is necessary to use corticosteroids in combination with bronchodilators. Inhaler Seretide Evohaler is prescribed to patients with bronchial asthma who use inhaled corticosteroids and short-acting beta-adrenomimetics, and in whom poor control of the disease is noted.
Seretide Diskus is prescribed for the therapy of reversible obstructive diseases of the respiratory system, including asthma in children and adults, if it is necessary to carry out combined treatment with bronchodilator and inhaled corticosteroid. Seretide Diskus is indicated for patients who receive maintenance doses of inhaled corticosteroids and selective beta2-adrenomimetics with prolonged action.
It is used for the treatment of patients in whom glucocorticosteroids alone exhibit signs of obstructive respiratory diseases. It is also prescribed to people receiving bronchodilators if necessary to prescribe corticosteroids for inhalation.
Seretide Diskus is also used as a basic medicine for people with chronic obstructive pulmonary diseases (including chronic bronchitis, emphysema).
Seretide Multidisk is used for the therapy of bronchial asthma in people who need combined treatment with inhaled glucocorticosteroids and long-acting beta2-adrenomimetics.
It is used as a starting support for patients with persistent bronchial asthma if they have indications for the appointment of GCS.
Used as a supportive treatment for chronic obstructive lung diseases.
Seretide is not used to treat people who have an intolerance to fluticasone, salmeterol or additional substances.
Do not use the remedy for exacerbations of the disease and acute health problems.
With caution is prescribed to people with active tuberculosis or with latent tuberculosis, as well as patients suffering from cardiovascular diseases, diabetes, hypokalemia.
Seretide Multidisk is not prescribed for the treatment of patients with chronic bronchitis, with high sensitivity to the components of the drug.
It is cautiously prescribed for people suffering from tuberculosis, infectious diseases of respiratory organs of viral, bacterial and fungal nature, diabetes mellitus, thyrotoxicosis, uncontrolled hypokalemia, pheochromocytoma, arterial hypertension, arrhythmia, IHD, cataracts, hypothyroidism, glaucoma, osteoporosis.
When taking Seretide, there may be some side effects. In particular, the use of Seretide Evohaler can provoke such side effects:
nausea, dyspepsia, hyperglycemia;
nervousness, sensation of causeless anxiety, problems with sleep, headache, tremor, behavior changes;
Cushing's syndrome, Cushingoid symptoms, violation of the process of bone mineralization, suppression of adrenal function, in children - growth retardation;
tachycardia and extrasystole, atrial fibrillation;
nasopharyngitis, sinusitis, irritation of the mucous throat, paradoxical bronchospasm;
urticaria, rash on the skin, angioedema, anaphylactic shock;
bronchitis, pneumonia, cataract, muscle spasm and muscle pain, glaucoma, arthralgia;
hoarseness and candidiasis of the cavity of the throat and mouth.
There is a higher probability of side effects provoked by the effects of fluticasone in children. It is necessary to clearly monitor the health of the child when treating the drug.
The development of similar side effects, which are due to the influence on the body of fluticasone and salmeterol, can be noted with the use of the means of Seretide Diskus. When treating this drug, paradoxical bronchospasm may develop, after inhalation, dyspnea immediately increases.
Similar side effects develop and when treated with Seretide Multidisk, which also contains salmeterol and fluticasone propionate.
Instructions for use Seretide (Method and dosage)
Seretide Evohaler is used by inhalation. The instruction on Seredit provides that the remedy is taken by patients with asthma as a prophylaxis, that is, it must be used constantly, even during periods of absence of asthmatic attacks.
After the beginning of the use of the drug, it is necessary to conduct regular patient studies, as this will enable to select the minimum effective dose of the drug. But adjusting the dose without the approval of a doctor is prohibited. If it is necessary to use a beta2 receptor agonist, it is recommended to use Seretide Evohaler once a day. At mostly night attacks it is used in the evening, with daytime attacks - in the morning.
The inhaler is used as follows: if this happens the first time, or if the can is not used for seven days, it is necessary to remove the cap of the mouthpiece and at first to spray once into the air. Each time before use, the inhaler should be shaken. When sprayed, the inhaler is held vertically. You need to take a deep breath, grasp the mouthpiece and spray the remedy once for inspiration. After this, it is desirable to hold your breath for a while. If you need to enter a second dose, then before you need to wait 30 seconds. After a while, it is advisable to thoroughly rinse the cavity with water. After use, the mouthpiece must always be closed with a cap.
If necessary, children should be helped to use the inhaler, making sure that the spray is carried out on inhalation. Clean the inhaler at least once a week.
The dosage of Seretide Evohaler and the duration of the course of admission are determined by the doctor. Depending on the degree of severity of the disease, two doses of Seretide Evohaler (25 mcg / 50 mcg, 25 mcg / 125 mcg, 25 mcg / 250 mcg) twice a day are prescribed for adults and children from 12 years of age. When the total control over the diseases is achieved, the dose can be revised.
Children from 4 years are prescribed one dose of Seretide Evohaler 25 μg / 50 μg twice a day.
The withdrawal of the drug is carried out gradually, with a sharp suspension of treatment, a person's condition may worsen.
The instruction for Seretide Diskus provides that the drug is used constantly, even in the absence of asthmatic attacks. Duration of treatment and dosage is determined by the doctor. To conduct the inhalation, you must initially open and charge the device from the plastic. Further inhalation is carried out as with the use of the drug Seretide Evohaler. The number of remaining doses can be seen on the dose indicator.
Adult patients and children after 12 years of age usually receive a single dose of Seretide Diskus (50 μg / 100 μg, 50 μg / 250 μg, 50 μg / 500 μg) twice a day. If short-term corticosteroid treatment is needed, two doses of drugs may be administered twice a day. Such a treatment regimen should not last longer than two weeks.
Children from 4 years are prescribed one dose of Seretide Diskus 50 μg / 100 μg twice a day.
Cancellation should be done gradually.
Instructions for use Seretide Multidisk provides the use of the product only for inhalations. Dosage, duration of treatment is determined by a specialist individually.
Adults and children after 12 years are usually prescribed one inhalation of Seretide Multidisk (50 μg / 100 μg or 50 μg / 250 μg or 50 μg / 500 μg) twice a day. If necessary, it is possible to use two doses of drugs twice a day. Such a therapy regimen should not last longer than two weeks.
Children from 4 years are prescribed one dose of LS 50 μg / 100 μg twice a day.
If too large doses of Seretide are used, an overdose of both salmeterol and fluticasone may be noted.
An overdose of salmeterol can lead to the development of tachycardia, tremor, headache, hypokalemia. With the signs of such an overdose, the use of cardiosel beta-adrenoblockers is indicated. People with hypokalemia are shown potassium preparations.
Overdose of fluticasone leads to the development of reversible suppression of adrenal function. This condition passes in a few days. Chronic overdose can trigger the development of Cushing's syndrome, growth retardation, disruption of bone mineralization. To prevent a chronic overdose, it is necessary to ensure close monitoring of the patient's condition.
Before you buy Seretide online you should know the drug interaction
It is not recommended to appoint Seretide Evohaler at the same time as selective and non-selective beta2-adrenoblockers. This combination is possible only if there are serious indications.
The effectiveness of salmeterol can be increased when it is used in conjunction with other beta-adrenomimetics.
The concentration in the plasma of fluticasone and salmeterol may increase with simultaneous use of ritonavir and other drugs that inhibit cytochrome P450 3A4. This increase leads to an increase in the systemic effect of fluticasone.
A slight increase in the concentration of salmeterol in the plasma is possible with the simultaneous administration of moderate inhibitors of CYP3 A4.
The combined use of Seretide and GCS, xanthine derivatives and diuretics increase the risk of hypokalemia.
Simultaneous treatment of tricyclic antidepressants and MAO inhibitors increases the risk of side effects in the functions of the cardiovascular system.
Seretide Evohaler and Seretide Diskus must be stored and transported at a temperature of 15 to 25 degrees, in the original packaging. The container should be protected from direct sunlight, fire, high temperature.
Seriety Multidisk must be stored in a temperature mode that does not exceed 30 ° C. The drug should be protected from access by children.
Seretide Evohaler can be stored for 2 years.
Seretide Diskus and Seretide Multidisk can be stored for 1.5 years.
A patient with bronchial asthma should initially learn how to use the inhaler correctly.
It is recommended to regularly monitor the growth rates of children who receive long-term inhaled glucocorticosteroids.
Rarely with the treatment of the drug there is an increase in blood glucose, so the patient with diabetes mellitus is prescribed with caution.
Seretide is not used for therapy of children who have not yet reached the age of 4.
In pregnancy and lactation
There is not enough research on the use of Seretide for pregnant women and nursing mothers. Therefore, during pregnancy, the drug is acceptable to use only if there are life indications. For future mothers who undergo such treatment, it is important to constantly be observed by a doctor who will adjust the dose of the drug.
When treating Seretide, women during breastfeeding should stop breastfeeding.
Reviews about Seretide
People who have practiced the treatment of bronchial asthma with the drug Seretide Evohaler or other varieties of this remedy leave feedback and continued and successful use of the remedy. People who write reviews on the forum, note that side effects are almost not observed. Leaving comments about Seretide Multidisk and others, their authors note that after applying the drug it is always desirable to rinse the oral cavity to avoid candidiasis. It is important to take Seretide only according to the scheme that the doctor has determined and use it regularly.