Allopurinol 100mg #50

Instruction for Allopurinol

You can buy Allopurinol here

Composition

Contains in its composition active substance allopurinol in the amount of 100 or 300 mg, as well as auxiliary substances.

Form of issue

Tablets of 100 or 300 mg.

pharmachologic effect

Anti-arthritis agent.

Pharmacodynamics and pharmacokinetics

The principle of action is based on the inhibition of xanthine oxidase, preventing the process of transition of hypoxanthine to xanthine, from which uric acid is formed. The drug reduces the concentration of salts of uric acid, uric acid itself in liquid media in the human body.
The drug prevents the formation of urate deposits in the renal system, in the tissues of the body, facilitates their dissolution. Allopurinol by reducing the transformation of hypoxanthine to xanthine leads to their enhanced use in the process of synthesizing nucleotides into nucleic acids. With the accumulation of xanthines in the plasma, the normal exchange of nucleic acids does not change, the precipitation process is not disturbed, and xanthines do not precipitate in the plasma, due to their high solubility. With the excretion of xanthines with urine, the risk of nephrourolythiasis does not increase.

Indications for use of Allopurinol

Consider what the drug is used for.
The medication is used for diseases accompanied by hyperuricemia: kidney stone disease, gout. The drug is prescribed for psoriasis, radiation and cytostatic therapy of tumors, hyperuricemia, hemablastosis (lymphosarcoma, chronic myelogenous leukemia, acute leukemia), massive therapy with glucocorticosteroids, extensive traumatic lesions (Lesch-Nichin syndrome), and violation of purine metabolism in children.
There are also the following indications for the use of Allopurinol. The drug is prescribed for uricosuria with recurrent mixed oxalate-calcium kidney stones, with urinary acid nephropathy with impaired renal function (renal failure).

Contraindications

Allopurinol is not prescribed for chronic renal failure in the azotemia stage, with intolerance to the active ingredient, in pregnancy, acute gout, hemochromatosis, breastfeeding, asymptomatic hyperuricemia.
With arterial hypertension, kidney pathology, diabetes mellitus, the drug is prescribed with caution.

Side effects

Sense organs: amblyopia, distortion of taste perception, cataract, visual impairment, loss of taste sensations, conjunctivitis.
Nervous system: drowsiness, depression, paresis, neuritis, headache, paresthesia, peripheral neuropathy.
The digestive tract: diarrhea, dyspepsia, epigastric pain, vomiting, nausea, increased liver enzymes, cholestatic jaundice, hyperbilirubinemia, granulomatous hepatitis, hepatomegaly, hepatonecrosis are rare.
Cardiovascular system: vasculitis, bradycardia, increased blood pressure, pericarditis.
Musculoskeletal: myalgia, myopathy, arthralgia.
Genitourinary system: peripheral edema, gynecomastia, infertility, hematuria, increased urea levels, proteinuria, acute renal failure, decreased potency, interstitial nephritis.
Organs of hematopoiesis: anemia, agranulocytosis, leukopenia, eosinophilia, thrombocytopenia, aplastic anemia.
From allergic reactions are possible: multiform exudative erythema, urticaria, skin itch, rash, bronchospasm, exfoliative dermatitis, eczematous dermatitis, purpura, toxic epidermal necrolysis, bullous dermatitis.
Also, nosebleeds, dehydration, alopecia, furunculosis, hyperthermia, lymphadenopathy, necrotic angina, hyperlipidemia are possible.

Allopurinol tablets, instructions for use (Method and dosage)

The drug is taken after meals, inside. It should be washed down with plenty of water. A dose of more than 300 mg is taken in divided doses. The course and duration of treatment depend on the severity of the disease.

How to take with gout

With mild symptoms of gout, 200-300 grams of the drug are recommended daily for admission. In severe form, with tofusov prescribed 400-600 mg daily. The daily amount of the drug can be divided into 2 divided doses. A dose of more than 300 mg in the treatment of gout is taken fractional.
The minimum effective dose is 100-200 mg / day. In order to reduce the risk of exacerbation of gout therapy it is recommended to start with small dosages: 100 mg per day, followed by a 100 mg dose increase every week.

Also

When chemotherapy for malignant blood diseases is used to prevent urate nephropathy, 600-800 mg per day are prescribed for three days, drinking is necessary.
Elderly people are prescribed the minimum dosage of the drug Allopurinol.
Children under 10 years are prescribed 5-10 mg per kg of body weight per day. For children 10-15 years, a dosage of 100-300 mg per day is used.
Instructions for use Allopurinol Egis and Allopurinol Sandoz are similar to the above dosage method.

Overdose

It is manifested by oliguria, dizziness, vomiting, diarrhea, nausea. It is recommended that peritoneal dialysis, hemodialysis be performed, forced diuresis is effective.

Interaction

Urikozuric medicines increase the renal clearance of the active metabolite oxypurinol, in contrast to thiazide diuretics, which increase toxicity and slow kidney clearance.
Allopurinol enhances the effect of hypoglycemic, oral agents. The drug inhibits metabolism, increases the concentration, and accordingly, the toxicity of methotrexate, mercaptopurine, azathioprine, xanthines, adenine arabinoside. When taking acetylsalicylic acid and colchicine, the effectiveness of the drug increases. Allopurinol prolongs the half-life of coumarin anticoagulants, which leads to an increase in the hypoprothrombinemic effect.
The frequency of skin rash increases with the appointment of amoxicillin, Ampicillin. The risk of developing bone marrow aplasia increases with doxorubicin, cyclophosphamide, procarbazine, bleomycin. Accumulation of iron in the liver is observed with the joint intake of allopurinol and iron preparations.
In renal failure, a combination with ACE inhibitors leads to an increased risk of toxicity. Nephrotoxicity is observed with the administration of cyclosporine. Antihyperuricemic effects are reduced with the use of ethacrynic acid, furosemide, thiazide diuretics, pyrazinamide, thiophosphamide, uricosuric drugs.

Storage conditions

In a dark place inaccessible to children at a temperature of no more than 30 degrees Celsius.

Shelf life

Not more than three years.

special instructions

Allopurinol is not recommended for use in asymptomatic uricosuria. Adequate therapy can lead to the dissolution of large urate stones in the calyx-pelvis system with the exit to the ureter and the formation of renal colic.
The medicinal preparation for children is prescribed exclusively with the congenital pathology of purine metabolism, with malignant neoplasms. It is inadmissible to begin treatment until the complete relief of an attack of acute gout. In the first month of therapy, prescribe drugs of the NSAID group, colchicine. When developing an acute attack of gout, anti-inflammatory drugs are added to the treatment regimen.
If the hepatic, renal system is disturbed, the dosage of allopurinol is reduced. The drug can be combined with a species of arab under the supervision of a doctor, with caution.

Allopurinol and alcohol

The drug is not compatible with alcohol.

Reviews about Allopurinol

The drug is effective as a medicine for gout, a decrease in the level of uric acid and edema, provided that the instructions for use and compliance with the diet.
However, there are many negative reviews about Allopurinol-Aegis, some people did not help the drug, and, moreover, caused side effects.