Colofort tabs #100

Instruction for Colofort

You can buy Colofort here

Form of release, composition and packaging

Tablets for resorption from white to almost white, flat-cylindrical shape, with a risk and chamfer; on the flat side with a mask MATERIA MEDICA inscription, on the other flat side there is inscription KOLOFORT.
1 tab.
antibodies to the human tumor necrosis factor alpha (TNF-α) affinity purified 0.006 g *
antibodies to the brain-specific protein S-100 affinity purified 0.006 g *
antibodies to histamine affinely purified 0.006 g *
* are applied to lactose in the form of a mixture of three active water-alcohol dilutions of the substance diluted 10012, 10030, 100200 times, respectively.
Excipients: lactose monohydrate, microcrystalline cellulose, magnesium stearate.

pharmachologic effect

It has been shown experimentally that the components of the preparation modify the activity of ligand-receptor interaction of endogenous regulators with corresponding receptors: antibodies to the S-100 protein to serotonin receptors and σ1 receptors; antibodies to TNF-α - to the TNF-α receptor; antibodies to histamine - to the histamine H4 receptor localized in the gastrointestinal tract.
The combination of the three active components allows a complex effect on the central and peripheral links of the pathogenesis of functional disorders of the intestine, including. abdominal pain syndrome.
Antibodies to protein S-100 have a wide spectrum of psychotropic activity, including anxiolytic and antidepressant, anti-asthenic and nootropic effects, which clinically manifests itself in the elimination of internal tension, anxiety, and normalization of a number of visceral functions, incl. activity of the large intestine. Do not have sedative, addictive, withdrawal symptoms.
Antibodies to TNF-α have a pronounced anti-inflammatory effect, contribute to the normalization of the balance of proinflammatory and anti-inflammatory cytokines.
Antibodies to histamine have antispasmodic, anti-inflammatory, anti-edematous action.
Combined use of components in the complex preparation contributes to the normalization of nervous and humoral regulation of bowel function; decrease visceral hypersensitivity of colon receptors to stretching, providing restoration of impaired motility of the gastrointestinal tract; a cupping sensation of bloating and stomach overflow, a reduction in the severity of the pain syndrome. The antispasmodic effect of Colofort is manifested by relaxation of the smooth muscle and a decrease in the tone of the gastrointestinal wall, a decrease in intraluminal pressure, normalization of the consistency of the stool, its frequency and accompanying symptoms (cupping imperative urges, tenesmus, feelings of incomplete bowel movement, additional efforts in the act of defecation, etc.).

Pharmacokinetics

The sensitivity of modern physicochemical methods of analysis (gas-liquid chromatography, high-performance liquid chromatography, chromatography-mass spectrometry) does not allow to estimate the content of ultra-small doses of antibodies in biological fluids, organs and tissues, which makes it technically impossible to study the pharmacokinetics of the preparation Colforth.

Indications for Colofort

- irritable bowel syndrome;
- functional disorders of the gastrointestinal tract.

Contraindications

- increased individual sensitivity to the components of Colofort.

Dosage

Colofort is taken orally, 2 times / day. At one time - 1 or 2 tablets (keep in your mouth until completely dissolved - not during meals).
The course of treatment is 1-3 months; If necessary, the course of treatment can be extended to 6 months and / or repeat after 1-2 months.
Against the background of exacerbation of diseases, it is possible to increase the frequency of admission up to 4 times / day for a period of 7 to 14 days.

Side effects of Colofort

Possible reactions of increased individual sensitivity to the components of Colofort.

Overdose

In case of an accidental overdose, dyspepsia is possible due to the excipients included in the formulation.

Drug Interactions

To date, cases of incompatibility with other medicinal products have not been reported.

special instructions for Colofort

The composition of Colofort includes lactose, and therefore it is not recommended for patients with congenital galactosemia, glucose malabsorption syndrome or galactose, or with congenital lactase insufficiency.

Impact on the ability to drive vehicles and manage mechanisms

Colofort does not affect the ability to drive vehicles and other potentially dangerous mechanisms.

Conditions of leave from pharmacies

You can buy Colofort without a prescription.

Terms and conditions of storage

The drug should be stored out of reach of children, protected from light at a temperature of no higher than 25 ° C. Shelf life - 3 years. Do not use after the expiration date.