Janumet 500mg + 50mg #56

Instruction for Janumet 500mg + 50mg

You can buy Janumet online

The drug Janumet's instructions for use describes how to use a protivodiabetic drug, which is used to reduce blood sugar. The effectiveness of the drug is enhanced by additional active substances that are included in the drug. When do they prescribe and how to take the medicine correctly?

Composition and properties

The main active substance in the preparation is metformin hydrochloride. In 1 tablet there may be 500, 850 mg or 1000 mg of substance depending on the dosage. In each of the tablets is 50 mg of sitagliptin. The dosage of this substance does not change depending on the amount of metformin. The composition of the drug includes other components that do not have a curative effect.
Each of these components has certain properties. The combination of two antidiabetic drugs improves the control of hypoglycemia in patients with type 2 diabetes mellitus. Metformin is a representative of the biguanide class, and sitagliptin is an inhibitor of dipeptidyl peptidase-4.
The action of sitagliptin is provided by the activation of incretins. When DPP-4 is inhibited, the concentration of hormones regulating glucose homeostasis increases. If the blood glucose level is normal, hormones increase the synthesis of insulin. Due to increased tolerance to glucose, which occurs due to metformin, blood glucose levels decrease, insulin sensitivity is increased.
The maximum concentration of sitagliptin in the blood is reached in 1-4 hours. Bioavailability of the substance is about 90%. Metformin begins to act 2.5 hours after admission. Absorption level is about 60%. The maximum concentration of metformin is achieved after 1-2 days. Metformin is not recommended for taking with food, as it reduces the effect of the drug component.
About 80% of metformin is excreted in the urine, there is no metabolism of this substance in the body. Sitagliptin is also excreted in the urine, the metabolism of this substance is minimal. Correction of the dosage of medication is necessary for patients with impaired renal function. With liver diseases, dosage adjustment is not required.

Indications and contraindications

Januet 1000 50 and other dosages of the drug are intended for the treatment of type 2 diabetes. You can apply the medicine in the following cases:
    As a supplement to diet and exercise for patients with a view to controlling hypoglycemia, if these patients did not give metformin therapy good results, and treatment correction is required.
    The medication is used with the addition of sulfonylurea derivatives, if the patients do not normalize after taking sulfanylurea and metformin derivatives. In this case Janumet acts as an addition to the diet and physical loads.
    Janumet is used in combination with gamma-receptor agonists if it is necessary for therapeutic purposes.
    The medication is prescribed concomitantly with the intake of insulin if the previous therapy has not achieved positive results.

As contraindications to Janumet, the following states are indicated:

    individual sensitivity to the components of the drug;
    diabetic coma;
    kidney diseases;
    infectious diseases;
    shock states;
    intravenous administration of substances with iodine content;
    heart disease and other pathologies that can lead to oxygen starvation of the tissue;
    impaired liver function, alcoholism, intoxication;
    lactation;
    Type 1 diabetes.

Among the side effects of Janumet, the instruction for use indicates:

    migraine;
    drowsiness;
    cough;
    nausea and pain in the abdomen;
    constipation, flatulence;
    vomiting;
    pancreatic diseases;
    edema.
With any side effects, you should report a negative reaction to the doctor, who will correct the appointment.

How to apply?

The dosage of tablets should be determined by the treating doctor. The medicine should be taken twice a day with food. To the drug did not bring the body side effects, the dose is increased gradually. There are some states in which you need to exercise maximum caution when taking Janumet:
    Acute pancreatitis. The intake of sitagliptin is capable of provoking an increase in the disease. The patient must be warned about this. If pains appear in the right hypochondrium or abdomen, Yanunet's appointment should be canceled.
    Lactic acidosis. This condition is very common. It occurs in people with diabetes or kidney disease and can lead to death. When appointing Janumet, you need to assess how risky his administration is in lactic acidosis, since this condition is characterized by abdominal pain, shortness of breath, hypothermia, changes in blood characteristics, and can lead to seizures, asthenia, digestive disorders. If negative reactions become apparent, the drug is immediately stopped taking the drug.
    Hypoglycemia. In a calm state, when taking Janumet, hypoglycemia does not occur. It can develop against a background of malnutrition or heavy physical exertion, with adrenal and pituitary diseases, alcohol abuse, and beta-blocker therapy. Risk of hypoglycemia may occur with simultaneous use with insulin.
    Renal failure. Lactic acidosis rises with renal failure, so it is necessary to monitor the level of creatinine in the blood. Elderly people need to be neat while taking medication, as they often have asymptomatic kidney disorders.
    Hypersensitivity. Such a reaction of the body is observed very often. If hypersensitivity is suspected, the medication should be withdrawn.
    Operation. If the patient is to undergo surgery, a couple of days before the operation, they stop taking Janumet.
    Iodine containing preparations. With simultaneous use of medications with iodine and Janumet, renal failure may occur.
    Patients with type 2 diabetes need to take all the necessary blood tests before appointing Janumet. If acidosis develops, the medicine should be withdrawn or replaced.

Studies during pregnancy were conducted only on animals and did not reveal any abnormalities in the development of the fetus when metformin was used. However, to eliminate the negative effect of taking Janumet during pregnancy is prohibited. If a woman has taken the drug before pregnancy, with the beginning of bearing the child, the drug should be stopped. Since metformin penetrates into breast milk, Janumet is also banned during breastfeeding.
The reaction to the management of vehicles or complex mechanisms of metformin is not affected. However, sitagliptin provokes weakness, drowsiness, so it is better to refuse from taking complicated medications when taking the medication. In case of an overdose of the medicament, lactacidosis may occur, which is affected by the increased dosage of metformin. When exaggerating the dose, standard measures are taken to prevent intoxication.

Patient's opinions

Janumet's reviews are contradictory. On the one hand, there are opinions of patients who claim that Janumet helped them improve the condition and reduce the sugar level. In this case, no side effects occurred in patients. However, there are other reviews.
Because the drug is excreted by the kidneys, older people could not drink tablets, as they caused side effects. For the same reason, the medication was contraindicated for people with kidney disease. They were forced to simply abandon it.
Marina, Moscow. I heard about Janumet from a friend. She was delighted with the medicine and advised him. However, the purchase was in vain. Janumet is contraindicated in renal failure. I have chronic pyelonephritis, so I could not take medication.
Vladimir, Krasnoyarsk. Began to take Janumet on the recommendation of a doctor. He remained satisfied. The level of sugar decreased, the condition improved.
Janumet is an effective medication. However, with prolonged use, the kidneys suffer, so patients with any pathologies of this body need to abandon the medicine and pick up an analogue.