Kreon 25000 300mg #20

Kreon instruction for use

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A preparation containing enzymes of the digestive tract

Form of preparation, its composition and packaging

Kreon 25000 is available as capsules of gelatinous solid. They are an enteric dosage form. The size of capsules is №0. The capsule is transparent, colorless, and the lid to it is characterized by orange coloration. Inside the capsule are placed minimocrosses, pale brown.
1 capsule Kreon 25000 contains 300 mg of pancreatin. In terms of enzymes, it is: 25,000 units of lyase, 18,000 units of amylase and 1,000 units of protease. In addition, the contents of the capsule contain additional substances: Macrogol 4000, dimethicone, cetyl alcohol, hypromelose phthalate, triethyl citrate.
The capsule shell consists of: gelatin, dyes of red and yellow iron oxides, titanium dioxide, sodium lauryl sulfate.
Capsules in the amount of 20.50 or 100 pieces are placed in vials made of high-density polyethylene. The bottle is sealed with a polypropylene lid, which is screwed on top. Vials are enclosed in cardboard packs with the appropriate marking and instructions.

Mechanism of action

Pancreatin is a natural enzyme that improves the processes of digesting proteins, fats and carbohydrates, their splitting and absorption into the total bloodstream.
The gelatin capsule dissolves in the stomach and the minimocrosses inside are mixed with the acidic contents of the stomach. Further this form of the drug is transported to the small intestine and dissolves there, evenly mixing with intestinal contents. Dissolution of the coating occurs at pH> 5.5. while in the lumen of the small intestine enzymes that break down proteins, fats and carbohydrates get to.

Pharmacokinetics

Since during the tests it was proved that there is no absorption of uncleaved enzymes into the total blood flow, it was not possible to conduct true pharmacokinetic tests. The drug works in the lumen of the small intestine and does not need absorption. The enzymes themselves are naturally proteins, therefore they also undergo a series of intestinal transformations and are converted into amino acids and peptides that can directly enter the blood.

Who and when is it recommended to take Kreon 25000

Kreon 2500 is recommended for treatment with the following diagnoses:
    cystic fibrosis
    chronic inflammation of the pancreas
    pancreas removal
    oncological pancreatic disease
    narrowing of lumen of gland ducts due to tumor
    oppressed enzyme-forming function, in particular in elderly people.
Also, the drug is used to eliminate symptoms of impaired digestion after:
    Gallbladder Removal
    partial or complete removal of the stomach
    narrowing of the lumen of the bile ducts
    inflammation of the liver with cholestasis
    cirrhosis of the liver
    small intestinal dysbiosis
    pathological changes in the intestine.

Who and when is it not recommended to take Kreon 25000

The drug is contraindicated if the patient has:
    Acute inflammation of the pancreas
    exacerbation of chronic inflammation of the pancreas
    individual intolerance of the ingredients of the drug.

How to use

Kreon 25000 is intended for oral administration. It is rational to take half or a third of the dose before eating, and the remaining amount directly during meals. The necessary dose is selected individually, depending on the level of enzyme deficiency and the quality of the diet.
The capsule or the minimocrosses extracted from it should be swallowed without chewing, with plenty of liquid.
If the patient has problems with swallowing (children, elderly people), then the Kreona 25000 capsule can be opened and drunk its contents. Do not store minimocrosses in a dissolved form, this solution must be taken immediately after preparation.
It should be monitored for sufficient drinking regimen to avoid constipation.
The reception of minimocrosses should be carried out together with food, the acid level of which is not more than 5.5, since dissolution of the enteric-soluble shell will otherwise occur and the active substances will be exposed to acidic gastric juice.
Children under the age of 4 years with cystic fibrosis are recommended to take 1000 units per 1 kg of the child's weight in each meal. From the age of 4 the calculation is from 500 units per 1 kg of weight. The dose is determined by the general state of the body, the ability to control the steatori, as well as compliance with the correct regime and the nature of nutrition. Do not exceed the dose of lipase more than 10,000 units.
To correct pancreatic insufficiency, the dose is selected depending on the degree of dysfunction and the nature of the food used. The dose of lipase can be from 20 to 75 thousand units. if the patient takes light food there may be enough 5-10 thousand units of lipase. The drug should be taken regularly, with every meal.
The initial dose of lipase ranges from 10-25 thousand units during the period of consumption of the main volume of food. But in some cases, to eliminate steatorrhea, you should raise the dose to the figures of 20-50 thousand units.
For the convenience of dose selection, it is possible to combine various forms of Kreon release, namely 25,000, 10,000 and 40,000.

Symptoms of an overdose of Kreon 25000

Taking excessively high doses of Kreon 25,000 is accompanied by an increase in the level of uric acid in the blood and urine.
Therapy: withdrawal of the drug, elimination of overdose symptoms.

Interaction Kreon 25000 with other medicines

There is no evidence of clinically significant interactions of Kreon 25000 with other drugs.

Application of Kreon 25000 during pregnancy and lactation

You are allowed to take Kreon 25000 during pregnancy or breastfeeding only if the benefit to mother / child risk ratio is estimated. There is no accurate information confirming the complete safety of the drug in this category of patients.

Side effects

From the gastrointestinal tract: pain in the abdomen, constipation, change in the consistency of the stool, frustration, vomiting and nausea.
From the side of the allergic status: rashes, individual hypersensitivity.

How to store

Kreon 25000 is recommended to be stored at a temperature of no higher than 250 ° C, which are caked in sebum, no more than 3 years from the date of release. Keep away from children. After opening the vial, you should take the capsule within 6 months, otherwise they will lose their fitness for use.

Conditions of leave from pharmacies

Kreon 25000 belongs to the list of OTC medicines, there is no need to present a prescription for its purchase in the pharmacy.

special instructions

It is not recommended to use Kreon 2500 in the early days of acute pancreatic inflammation.
You should regularly monitor the condition of children with a diagnosis of cystic fibrosis. Which consistently accept Kreon 25000.
Kreon 25000 does not violate the ability to drive a car and control other mechanisms requiring attention and speed of reactions.