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No-spa 40mg #64

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No-spa user manualYou can buy No-spa on this pageNo-spa tablets are a representative of the clinico-pharmacological group of antispasmodics. They reduce the tone of the smooth muscles of the walls of hollow organs and are used for..

No-spa user manual

You can buy No-spa on this page

No-spa tablets are a representative of the clinico-pharmacological group of antispasmodics. They reduce the tone of the smooth muscles of the walls of hollow organs and are used for various pathological processes accompanied by spasms.

Form of issue and composition

The No-spa tablets are small in size, round in color and yellow in color. The main active substance of the drug is drotaverine. Its content in one tablet is 40 mg. It also includes auxiliary components, which include:
    Lactose monohydrate.
    Talc.
    Corn starch.
    Povidone.
    Magnesium stearate.
No-spa tablets are packaged in a blister pack of 6 and 24 pieces, and also in glass bottles of 60 and 100 pieces. A cardboard pack contains one blister or bottle with the appropriate number of tablets, as well as instructions for the use of the drug.

pharmachologic effect

The active substance of the No-spa tablets drotaverine is a chemical derivative of isoquinoline. It suppresses the enzyme phosphodiesterase (PDE 3), which catalyzes the conversion of cyclic AMP (adenazine monophosphoric acid) into AMP. An increase in the concentration of cyclic AMP in smooth muscle cells leads to activation of the process of phosphorylation of the enzyme kinase of light chains of myosin, responsible for the reduction of smooth muscle fibers. Also, the drug reduces the concentration of calcium ions inside the smooth muscle cells, which additionally leads to a relaxation of smooth muscles. No-spa tablets have an antispasmodic effect on the smooth muscles of hollow organs, regardless of the activity of the autonomic nervous system, since they act directly on the smooth muscle cells. Also, the preparation has no effect on the functional state of the heart and blood vessels, which is due to the selective inhibition of the PDE enzyme 3.
After taking the No-pill tablets inside, drotaverin is quickly and completely absorbed from the intestinal lumen into the systemic bloodstream. It is evenly distributed in the tissues of the body and penetrates into the smooth muscle cells. Drotaverin does not penetrate the structures of the central nervous system through the blood-brain barrier. Also, it practically does not pass through the placental barrier into the developing fetus during pregnancy. The active substance of No-shp tablets is metabolized in the liver with the formation of inactive decay products, which are mostly excreted in the urine, a smaller part is excreted in the bile. Half-life (the period during which half of the total dose of the active substance of the drug is excreted from the body) is about 16 hours.

Indications for use

The reception of No-spa tablets is indicated for various pathological processes accompanied by spasms of smooth muscles of hollow organs:
    Spasms of smooth muscles of the hollow organs of the hepatobiliary system in cholelithiasis, cholecystitis (inflammation of the gallbladder), cholangitis (inflammation of the bile ducts of various locations).
    Spasms of the hollow structures of the urinary system in urolithiasis (nephrolithiasis, ureterolithiasis), inflammatory process in the renal pelvis (pyelonephritis), bladder (cystitis), tenesmus or localized bladder spasms.
As an auxiliary therapy, the drug is used in the pathology of the digestive tract, accompanied by spasms of hollow structures - peptic ulcer of the stomach or duodenum, inflammation of the small (enteritis) or thick (colitis) of the intestine, spastic colitis, irritable bowel syndrome. Also for additional treatment, No-spa tablets are used for headache and algodismorrhea (painful menstruation), while they are combined with non-steroidal anti-inflammatory drugs.

Contraindications

The reception of No-spa tablets is contraindicated in a number of pathological or physiological conditions of the body, they include:
    Individual intolerance to drotaverin or active ingredients of the drug.
    Severe kidney failure.
    A marked decrease in the functional activity of the liver.
    Acute or chronic heart failure in the stage of decompensation.
    Congenital lactose intolerance, lactase deficiency, glucose-galactose malabsorption is a condition of impairment and absorption of carbohydrates, in particular lactose, which is an auxiliary component of No-spa tablets.
    Children under 6 years old.
    The lactation period (breastfeeding) in women.
Before starting taking No-Shp tablets, make sure there are no contraindications.

Dosing and Administration

No-spa tablets are taken orally, they are not chewed and washed down with a sufficient amount of water. The average daily dose of the drug for adults is from 120 to 240 mg, divided into 2-3 doses. For children aged 6 to 12 years, the average daily dose should not exceed 80 mg in 2 divided doses, for children over 12 years - 160 mg in 2-3 doses. Self-administration of the drug is possible within a few days (no more than 3 days), in the future, if spasms of hollow organs persist, you should consult a doctor for advice.

Side effects

Against the background of the reception of No-spa tablets, it is possible to develop negative reactions from various organs and systems:
    Digestive system - nausea, constipation.
    Nervous system - headache, dizziness, insomnia.
    Cardiovascular system - more frequent heart contractions (tachycardia), lowering blood pressure (arterial hypotension).
    Allergic reactions - a rash on the skin, its itching, urticaria (characteristic manifestations on the skin in the form of nettle burn), angioedema Quincke (pronounced swelling of the skin and soft tissues of the external genital area and face), anaphylactic shock (severe systemic allergic reaction accompanied by pronounced a decrease in the level of arterial pressure and multiple organ failure).
If there are signs of side effects, taking No-Shp tablets should stop and consult a doctor.

special instructions

Before starting taking No-Shp tablets, read the instructions for the drug. There are several specific indications regarding their application, which include:
    In patients with impaired digestion and absorption of carbohydrates, the appearance of negative reactions from the digestive system is possible, this is due to the fact that the composition of the drug includes lactose.
    The use of the drug for pregnant women is possible only after the appointment of a doctor, if the expected benefit for the mother exceeds the potential risk to the fetus.
    The drug can interact with drugs of other pharmacological groups, so in case of their use, consult a doctor.
    The drug in the therapeutic dosage does not affect the functional state of the structures of the central nervous system. In the case of side effects, work associated with the need for increased concentration and speed of psychomotor reactions should be discontinued.
In the pharmacy network, No-spa tablets are dispensed without a prescription. If you have any doubts or questions about their use, you should consult your doctor.

Overdose

A significant excess of the recommended therapeutic dose of No-shp tablets can lead to a violation of the rhythm of cardiac contractions (arrhythmia), as well as to violation of intracardiac conductivity, up to a complete blockade with cardiac arrest. Treatment of overdose consists in washing the stomach, intestines, taking intestinal sorbents (activated charcoal), as well as conducting symptomatic therapy in a medical hospital.

Analogues of tablets No-spa

Similar in composition and active substance for No-spa tablets are preparations of Drotaverin.

Terms and conditions of storage

Shelf life of No-spa tablets is 3 years from the date of their manufacture. The preparation should be stored in the original original packaging, in a dark, dry place inaccessible to children at an ambient temperature of + 25 ° C.

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