Reduxin 10mg #30

Reduxin user manual

You can buy Reduxin online

The drug Reduxin refers to the pharmacological group of drugs for the treatment of obesity. It affects the central nervous system and is used to reduce appetite.

Composition and form of release

The drug Reduxin is available in the form of a capsule for oral administration. They have a blue or blue color (depending on the dosage), inside it is a powder of white or yellowish color. The composition of the drug includes 2 main active ingredients - sibutramine hydrochloride monohydrate (dosage of 10 and 15 mg in 1 capsule) and microcrystalline cellulose (dosage of 158.5 and 153.5 mg in 1 capsule). Also in the preparation contain auxiliary components, which include:
    Titanium dioxide.
    Calcium stearate.
    Gelatin.
    Dyes azorubin, patented blue.
Capsules Reduxin are packaged in a contour acheive box of 10 pieces. Cardboard pack contains 3 or 6 contour squares, as well as instructions for the use of the drug.

Pharmacodynamics and pharmacokinetics

Pharmacological action of capsules Reduxine is due to a combination of active ingredients of the drug. Sibutramine in the body is converted into active metabolites (primary and secondary amines) that inhibit the reuptake of certain neurotransmitters (mainly norepinephrine and serotonin), potentiating their accumulation in the synapses of the central nervous system. This causes an increase in the activity of serotonin and adrenaline receptors, due to which there is a feeling of saturation, and the psychological need for receiving a significant amount of food decreases. Also, sibutramine indirectly affects the beta receptors of brown adipose tissue, which leads to an increase in the intensity of the splitting of fats, an increase in the concentration of high-density lipoproteins in the blood, as well as a decrease in the level of low-density lipoproteins and triglycerides. This active substance of the drug has virtually no effect on the activity of other neurotransmitters and brain receptors. Microcrystalline cellulose, which is the second active ingredient in capsules Reduxine is an intestinal sorbent. It binds nutrient compounds in the intestines, preventing their absorption into the blood. Also, this compound reduces the severity of organism intoxication by binding various bacterial toxins, pathogenic (pathogenic) microorganisms, poisonous compounds entering the digestive tract from the outside.
After taking the capsule Reduxin, sibutramine is almost completely absorbed into the blood from the intestine. It passes through the liver, where it turns into active metabolites, which have a therapeutic effect. Active metabolites are evenly distributed in tissues, through the blood-brain barrier penetrate into the structures of the brain. Accumulation of the maximum therapeutic concentration of active metabolites of sibutramine in blood plasma occurs on the 4th day after the start of the course of therapy with the drug. Active components are metabolized in the liver again with the formation of inactive decay products, which are excreted mainly by the kidneys. Microcrystalline cellulose in the blood is practically not absorbed, but is excreted from the intestine with feces.

Indications for use

Receiving capsules Reduxin is indicated for reducing excess body weight with several pathological conditions of the body, accompanied by alimentary obesity with a body mass index (BMI) of more than 30 kg / m2. Also, the drug can be used with less severe obesity, which is accompanied by a concomitant pathology, in particular diabetes mellitus type 1 or type 2, dyslipoproteinemia.

Contraindications for use

Receiving capsules Reduxin is contraindicated in various pathological and physiological conditions of the body, which include:
    Obesity, the development of which is associated with hormonal changes in the body, in particular with hypothyroidism (insufficient functional activity of the thyroid gland).
    Severe eating disorders (bulimia nervosa or anorexia nervosa).
    Pathology affecting the psychic sphere.
    Generalized tics (uncontrolled twitching of skeletal muscles) - Gilles de la Tourette syndrome.
    The pathology of the cardiovascular system, including ischemic heart disease, chronic heart failure in the stage of decompensation, congenital heart valve defects, arrhythmias (violation of the frequency and rhythm of contractions of the heart), peripheral arterial pathology, accompanied by a violation of blood flow in them (occlusion), vascular damage and brain tissue (cerebral atherosclerosis, cerebral stroke), uncontrolled periodic increase in arterial pressure (arterial hypertension).
    Simultaneous use of drugs of the group inhibitors of the enzyme of the central nervous system monoamine oxidase (MAO) - fenfluramine, ethylamphetamine, phentermine, dexfenfluramine. It is also important not to start accepting Reduxin capsules within 2 weeks after the end of the course of therapy with drugs of this pharmacological group.
    Severe functional insufficiency of the liver and kidneys.
    Increased activity of the thyroid gland is thyrotoxicosis.
    Closed-angle glaucoma, accompanied by increased intraocular pressure.
    A benign hormone-producing tumor of adrenal medulla that leads to an increase in adrenaline-pheochromocytoma.
    Drug, alcohol or drug dependence.
    Pregnancy at any time of the course, as well as the period of breastfeeding (lactation).
    Age is 18 years and over 65 years.
    Established individual intolerance to any of the components of the drug.
With caution, Reduxin capsules are used for arrhythmia that has been diagnosed in the past, pathologies of the coronary arteries responsible for eating cardiac muscle, controlled arterial hypertension, motor or verbal tics, including those in the past, liver or kidney deficiency of moderate severity, cholelithiasis formation of stones in the hollow structures of the hepatobiliary system), neurological disorders, including mental retardation and convulsions.

Dosing and Administration

Reduxin Capsules are intended for oral administration. They are taken orally 1 time per day in the morning, regardless of food. Capsules are not chewed and washed down with a sufficient amount of water. The dosage is determined individually for each patient, depending on the therapeutic effect obtained, as well as the tolerability of the drug. The initial dose is 10 mg 1 time per day, with a poor tolerance of the drug, it can be reduced to 5 mg. In the absence of therapeutic effect within 4 weeks after the beginning of the drug (a decrease in body weight by at least 5% of the initial value), the dosage may be increased to 15 mg per day. The duration of the course of capsule therapy should not exceed 3 months, especially in patients with poor drug tolerance. Further use of the drug is impractical if, after discontinuing the course of therapy, the patient regains weight more than 3 kg. The total duration of therapy should not exceed 2 years, since safety in excess of such a period of time remains unexplored.

Side effects

After taking capsules Reduxin may develop negative reactions from various organs and systems:
    Cardiovascular system - a feeling of palpitations, increased heart rate (tachycardia), increased blood pressure, peripheral vasodilation (vasodilation). More pronounced changes in blood pressure and heart rate are more frequent at the beginning of the course of therapy.
    Digestive system - complete absence of appetite, constipation, less often develops nausea, exacerbation of hemorrhoids. In the case of a concomitant propensity to develop constipation during the initiation of the course of therapy with Reduxin capsules, it is mandatory to monitor the motor-evacuation function of the intestine.
    Nervous system - the appearance of dry mouth, the development of sleep disorders in the form of insomnia, rarely there may be a headache, a feeling of anxiety, dizziness, a violation of the sensitivity of the skin (paresia) and taste sensations. In isolated cases, emotional lability develops (sudden mood swings), anxiety, irritability, drowsiness, prolonged depression of mood (depression), seizures. Patients who have had psychiatric disorders prior to initiating the use of the drug may develop acute psychosis.
    Skin and subcutaneous tissue - increased sweating (hyperhidrosis), itching of the skin, in a few cases, possible bleeding in the skin (purple Shenlen-Genocha).
    General reactions of the body - influenza-like manifestations in the form of body temperature increase and general weakness, expressed thirst, women may have a menstrual cycle.
The most common side effects can develop within the first 4 weeks after taking capsules Reduxin. The doctor determines the necessity of drug cancellation in such cases individually. After discontinuation of the drug, withdrawal syndrome, accompanied by increased appetite, usually does not develop.

special instructions

To achieve the maximum therapeutic effectiveness, as well as prevent the development of complications and negative reactions, before taking the capsules Reduxin should carefully read the instructions to the drug, make sure there are no contraindications, and also pay attention to a few special instructions, which include:
    To increase the effectiveness of the drug should be combined with the implementation of dietary recommendations and increased motor activity. This should change the habits, eating behavior, which is necessary to keep the body weight at the same level after the drug is discontinued.
    The drug should be started only in the absence of the effect of other methods for weight loss (dietary recommendations, exercise).
    Prescribe capsules Reduxin for the treatment of obesity can only a doctor with sufficient experience of their application.
    During the course of therapy with the drug, the blood pressure and heart rate are monitored - during the first 2 months these parameters are determined 2 times a week, then 1 time per month. In patients with concomitant controlled arterial hypertension, blood pressure monitoring is performed more frequently and carefully. With a significant increase in blood pressure during a two-time measurement, the drug should be discontinued.
    The interval between the end of the intake of drugs of the pharmacological group MAO inhibitors and capsules Reduxin should be a period of at least 2 weeks.
    With caution, Reduxin capsules are used against the background of concurrent administration of drugs that can prolong the QT interval (antihistamines, drugs that enhance the motility of the gastrointestinal tract, antiarrhythmic medications) on an electrocardiogram.
    A reliable connection between taking capsules Reduxin and the development of pulmonary edema is not established. Nevertheless, it can not be excluded, so the appearance of signs of external respiration requires careful monitoring of the lungs.
    The drug can affect the speed of psychomotor reactions, the patient's ability to concentrate, therefore, it is not recommended to carry out potentially dangerous work, including driving vehicles.
In the pharmacy network, Reduxin capsules are dispensed only on prescription. The independent use of the drug is avoided in order to avoid the development of complications.

Overdose

There is no reliable data on the overdose of Reduxin capsules to date. Exceeding the recommended therapeutic dose may be accompanied by the development or increased side effects. In this case, you need to see a doctor who will prescribe the appropriate symptomatic therapy.

Terms and conditions of storage

The shelf life of Reduxin capsules is 3 years from the date of manufacture. They must be stored in the original factory packaging, dry place, inaccessible to children at an air temperature of no higher than + 25 ° C.