Zulbex tabs 20mg #14

Zulbex instruction

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Composition

In 1 tablet, rabeprazole sodium 10 mg or 20 mg.
Mannitol, magnesium oxide, giprolase and giprolose low-substituted, magnesium stearate, - as auxiliary substances.

Form of issue

Tablets in the enteric coating.

pharmachologic effect

Antisecretory, antiulcer.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Rabeprazole is an antisecretory drug that does not possess anticholinergic and antihistamine properties. Suppresses gastric secretion by inhibiting the enzyme H + / K + -AT Phase of the proton pump. This entails suppression of basal and stimulated secretion in the stomach. The effect of the drug is dependent on the dose.
Rabeprazole passes into the parietal cells, accumulates in them and enters the secretory tubules, where protonation takes place in the sulfenamide form. In this form it interacts with the cysteine ​​of the proton pump and irreversible inhibition occurs, which lasts 40 hours.
The antisecretory effect is observed after 60 minutes, the maximum of action is achieved after 3 to 4 hours. The inhibitory effect with repeated administration of the drug is slightly increased and after 3 days reaches the equilibrium state. After its withdrawal, the secretion in the stomach is restored after 3 days.
The bactericidal effect on Helicobacter pylori was established in vitro. In combination with antibiotics, a high level of H. pylori- 80% eradication is achieved and mucosal repair is accelerated.

Pharmacokinetics

The shell of the tablet is stable in the acidic environment of the stomach, it dissolves in the intestine, where the absorption takes place. The maximum concentration is determined after 4 hours, and its level depends on the dose taken. Bioavailability of the drug is 52%, it binds to proteins by 97%.
The elimination half-life is 90 minutes.

Indications for use

    exacerbation of peptic ulcer;
    GERD;
    eradication of Helicobacter pylori;
    erosive esophagitis;
    prevention of seasonal exacerbation of peptic ulcer;
    Zollinger-Ellison syndrome.

Contraindications

    pregnancy;
    hypersensitivity to the drug;
    breastfeeding period;
    childhood.

Side effects

    nervousness, dizziness, insomnia, depression, headache, confusion (very rarely);
    neutropenia, leukopenia, leukocytosis, thrombocytopenia;
    anorexia, weight gain;
    visual impairment;
    peripheral edema;
    cough, rhinitis;
    diarrhea, vomiting, dryness of the oral mucosa, nausea, belching, abdominal pain;
    rash, itching, erythema multiforme;
    back pain, myalgia, arthralgia, convulsions;
    gynecomastia (very rarely).

Instructions for use Zulbex (Method and dosage)

Tablets are administered orally, whole. They can not be chewed and broken.
When peptic ulcer is exacerbated, 20 mg 1 time, in the morning before breakfast, up to 4 weeks. If necessary, more.
    GERD with the presence of erosive reflux esophagitis - 20 mg 1 time, 4-8 weeks.
    GERD without erosive lesions -10 mg once a day for 4 weeks. Further 10 mg 1 time, on demand.
The initial dose for Zollinger-Ellison syndrome is 60 mg once a day with a further increase to 120 mg. Up to 100 mg of the drug is taken 1 time per day, and 120 mg are divided into 2 doses. Treatment until the disappearance of clinical manifestations of the disease.
Various combinations of drugs are used to eradicate H. pylori.
Instructions for use Zulbex contains a warning about the prescription of the drug to children. The study of drug safety in this age group of patients was not conducted.

Overdose

When taking Zulbex 160 mg once a day, there may be side reactions from a known list that go away on their own when the drug is withdrawn.
The antidote is unknown. If necessary, symptomatic treatment is performed.

Interaction

Zulbex causes a prolonged suppression of secretion in the stomach, so there is a possibility of interaction with drugs in which absorption depends on pH.
Concentrations of rabeprazole and the metabolite of clarithromycin in a joint admission are increasing.
All inhibitors of the proton pump can not be used with atazanavir. Does not interact with drugs that are metabolized by cytochrome CYP450 (Phenytoin, Warfarin, Amoxicillin, Theophylline, Diazepam).
Rabeprazole with the joint administration of ketoconazole, Itraconazole, digoxin reduces their concentration in the blood, so a correction of their dose is necessary.

Terms of sale

You don't need a prescription to buy Zulbex online.

Storage conditions

In a dry place, not more than 300 C.
Shelf life - 2 years.

Reviews of Zulbex

Reviews of Zulbex at the forums indicate the effectiveness of the drug. It refers to inhibitors of the newer generation of rabeprazoles, which are significantly more effective than omeprazoles and lansoprazoles. Preparations of this generation are taken once a day, which is very convenient in everyday life. This is also often noted at forums and in the answers of doctors of gastroenterologists. It can be fully attributed to high-quality medicines, which is successfully used if there is no possibility to purchase Pariet.
Despite the fact that the drug was taken by many a month or more, no significant side effects were noted. Of the most common undesirable reactions of the body, headache, bloating and constipation are noted.