Elevit Pronatal tabs #30

User manual for Elevit Pronatal

You can buy Elevit Pronatal online

Ingredients Elevit Pronatal

The main active ingredient of this pharmaceutical preparation is a vitamin complex including such biological substances as:
    vitamin A (retinol palmitate) - 3600 IU (international units);
    vitamin B1 (thiamine mononitrate) 1.6 mg;
    vitamin B2 (riboflavin) 1.8 mg;
    vitamin B5 (calcium pantothenate) - 10 mg;
    vitamin B6 (pyridoxine hydrochloride) - 2.6 mg;
    vitamin B9 (folic acid) - 0.8 mg;
    vitamin B12 (cyanocobalamin) - 4 mcg;
    vitamin C (ascorbic acid) - 100 mg;
    vitamin D (cholecalciferol) - 500 IU;
    vitamin E (dl-a-tocopherol acetate) - 15 mg;
    Vitamin PP (nicotinamide) - 19 mg;
    vitamin B7 (biotin) - 0.2 mg.
The composition of vitamins in each tablet of the drug is supplemented by a large number of various minerals, trace elements and their salts:
    pantothenate and calcium phosphate - 125 mg;
    phosphorus - 125 mg;
    magnesium stearate and phosphate - 100 mg;
    fumarate iron - 60 mg;
    zinc sulfate 7.5 mg;
    copper sulfate - 1 mg;
    manganese sulfate - 1 mg.

Composition of the film shell:

    polyethylene glycol 6000 and 400;
    Preciol of Ato 5;
    gelatin;
    microcrystalline cellulose (MCC);
    sodium carboxymethyl starch;
    povidone K 30 and K 90;
    lactose monohydrate;
    mannitol;
    magnesium stearate;
    ethylcellulose.

Form of issue

The Elevit Pronatal vitamin complex in pharmacy kiosks is presented in the form of oblong film-coated tablets, which are fixed in blisters of aluminum foil or PVC for 10 or 20 pieces.
Tablets of gray-yellow color have a biconvex form with a characteristic strip for breaking on one of the surfaces. There may be a smell that does not indicate the unfitness of the pharmaceutical product. The cardboard package accommodates 3 or 10 contouring platelets designed for 10 tablets or 5 blisters for 20 pieces.

pharmachologic effect

The medicinal effects of the pharmaceutical preparation Elevit Pronatal should not be considered in a complex, but in accordance with the constituent components, since all vitamins, trace elements and their derived salts are biologically active substances.
The main physiological role of vitamin A is the coordination of the normal formation of lipids, proteins and mucopolysaccharides in the proportions required by proliferating tissue. Due to this property, the body's ability to repair and regenerate damaged areas is maintained. Also, the vitamin provides a normal state of the skin and mucous membranes, since in large quantities it is found in the connective tissue and the upper layers of the epithelium. The component component of Elevit improves the functioning of the visual apparatus, in particular, the work of the eyes in the case of insufficient illumination ("twilight vision"), since it stimulates metabolic processes in the sticks, receptor cells of the retina.
The second name of vitamin B1 is antineuric, since this active component normalizes the work of the nervous system, promotes physiological renewal of the myelin sheath of nerve trunks and the natural course of electrical impulses. He also participates in the regulation of cardiac work - normalizes the heart rate and helps strengthen the muscle cells of the organ. Vitamin is a stimulating factor of hematopoiesis, which ensures timely updating of the blood composition and improves its microcirculation. As a coenzyme or a specific carrier involved in carbohydrate, protein, fat and water-salt metabolism.
Vitamin B2 is an indispensable part of the normal cycle of formation of red blood cells (erythrocytes) and antibodies. It has a beneficial effect on the mucosa of the digestive tube and the respiratory tract, as it contributes to its strengthening and timely renewal of the epithelial cover. Eliminates the effect of toxins entering the body through the respiratory tract. Participates in the physiological development of the tissues and organs of the fetus.
Pyridoxine hydrochloride or vitamin B6 is found in many metabolic processes. First of all, it lowers the concentration of cholesterol and lipids of low and very low density in the blood, showing an anti-atherogenic effect. Helps improve the contractility of the heart muscle, as it increases the supply of useful nutrients. Normalizes the work of the central and peripheral nervous system, activating more intense axonal transport and trophic neurons. Strengthens the cellular structure of bone tissue, teeth, gums and appendages of the skin (hair and nails). Stimulates hemopoiesis.
Cyanocobalamin - an indispensable element for the formation of normal blood cells. In combination with Hageman's factor localized on the surface of the stomach, it participates in iron absorption through active diffusion and transport it to the site of synthesis of the main blood cells-red blood cells. Thus, the oxygen exchange rate increases and gas delivery to peripheral tissues and organs improves. In the absence of vitamin B12 macrocytic megaloblastic anemia develops, as the physiological structure of red blood cells is disturbed. Also, the biologically active component normalizes circadian rhythms, improving sleep and regulating the waking hours.
Vitamin C is a powerful antioxidant factor of a natural nature. By binding free radical structures, it protects the cell wall from their damaging effect. Due to the stimulating effect on the immune system, one's own resistance to infectious diseases is increasing, therefore it is recommended to take it abundantly in winter, when the SARS threatens everyone. Also ascorbic acid is involved in the maturation of connective tissue, promoting the metabolic cycle of proline. Thus, the vitamin plays a role in the formation of bones, gums, teeth, strengthening the vascular wall of the microcirculatory bed. Participating in the digestive chain contributes to the normal absorption of calcium and iron.
The key role of vitamin D3 is to regulate the exchange of calcium and phosphorus in the body. Due to its pharmacological effects, trace elements are better absorbed from foods in the gastrointestinal tract, timely deposited in bone tissue and dentin, delayed their renal excretion. Complex action of the vitamin allows to resist osteomalacia and softening of bone tissue, destruction of teeth, due to the influence of endogenous and exogenous nature. Abundantly used in the prevention of rickets.

Alfa-tocopherol or fat-soluble vitamin E, like ascorbic acid, has strong antioxidant properties and is involved in the formation of collagen and elastic fibers of connective tissue and skin in particular (supports the regenerative capacity of the body to repair defects). The active component strengthens the capillary walls and improves blood circulation in the small diameter vascular bed, thus preventing the development of anemia and local blood insufficiency. Ensures the normal functioning of plasma and platelet coagulation systems. Takes direct part in the formation of red blood cells. In pregnancy, alpha-tocopherol spurs the formation of gonadotropins and regulates the development of placental tissue, so that it meets all the needs of the fetus.
Folic acid is one of the most necessary vitamins for a pregnant woman and when planning a future child. It contributes to the physiological formation of neuroblasts and embryonic neurocytes, which is important for the normal development of the central and peripheral nervous system. The course of folic acid during pregnancy can prevent the appearance of a large number of hereditary pathologies, for example, splitting of the neural tube, anencephaly, improper development of the spine and so on. Also, this vitamin strengthens the amniotic membrane, thereby preventing possible premature birth. For the mother's body, folic acid is not bad - it participates in the blood, as a stimulating factor, thus providing an anti-anemic effect.
Nicotinamide is an active coenzyme of a wide range of diverse metabolic reactions. For example, due to its action, lipid metabolism is activated and redox processes are normalized. Vitamin promotes synthesis of hormones of adrenals, regulating carbohydrate and water-salt metabolism. Takes part in immune reactions, providing a normal synthesis of antibodies in response to antigens.
The physiological role of calcium lies in the formation of the normal structure of bone tissue in the fetus. Due to the exogenous intake of the microelement, a bone embryonic leaf and the rudiments of the future dentin are laid. In combination with vitamin D, it provides active prevention of osteomalacia, calcium leaching from the mother's body and development of rickets in a child. Also, the microelement ensures the normal functioning of the cardiovascular system, as it takes a direct part in the mechanism of depolarization of cardiomyocytes and muscle contraction. Promotes the proper operation of the blood clotting system.
Like calcium, phosphorus participates in the laying of bone elements and teeth. A distinctive feature is the participation in energy metabolism - through chemical bonds with nucleotides, macroergic compounds, the so-called molecular energy depots, are formed. If necessary, these structures are destroyed under the influence of an internal environment factor and the cell or subcellular organelles receive the required amount of energy.
Iron is necessary for the synthesis of heme in hemoglobin. It is a protein structure that provides transport of oxygen and carbon dioxide in the erythrocyte. Without this micronutrient, the body would not be able to take and carry all the vital gas, like oxygen, in all tissues and organs, and to remove the produced waste in the form of carbon dioxide.
Zinc is an active component of various enzymes, protein catalysts of chemical reactions, which are mainly involved in the synthesis of glucocorticosteroids, adrenal hormones. Also, his influence extends to the state of derivatives of the skin - nails and hair.

Manganese plays an important role in the planning of pregnancy, as it promotes the activation of the reproductive function of the female body. Also, the microelement improves memory and reduces irritability, which has a beneficial effect if you take a micronutrient during the postpartum depression.
Magnesium, as a biological active ingredient, enters absolutely all tissues and organs of the human body. The greatest value it has in the formation of muscle and bone tissue.

Pharmacodynamics and pharmacokinetics

Elevit Pronatal is a complex pharmaceutical preparation containing a large number of various active ingredients whose pharmacokinetic capacities should be considered separately. However, unfortunately, not all metabolic chains of active components have been reliably studied.
Vitamin A is rapidly and quite fully absorbed from the gastrointestinal tract. The maximum plasma concentration of retinol is reached only 4 hours after taking the drug. It is deposited in Kupffer cells, whence it is gradually released into the main bloodstream after reaching the physiological level. Transport of vitamin A in the vascular channel is provided by specific globulins, which protects the biologically active component from filtration in the glomerular apparatus of the kidneys. Metabolized retinol in tissues with the final products of metabolism in the form of carbon dioxide, water-soluble vitamins and fatty acids. In the urine, the active component is not detected.
Ascorbic acid is absorbed by their gastrointestinal tract through the secondary active transport along the concentration gradient with the help of the sodium-ascorbate cotransporter, which exhibits the properties of stereospecificity. Further, vitamin C enters the main mole and is transferred to cells that metabolize without rest. In urine ascorbic acid is detected only when excessively exceeding the dosages of the active ingredient.
After oral administration of the pharmaceutical preparation, vitamin D is absorbed from the final sections of the small intestine with the participation of bile acids. In the blood, the active ingredient binds to albumins and g-globulins. Deposited cholecalciferol mainly in adipose tissue, because it is inherently fat-soluble vitamin. Metabolic transformations occur in:
    skin - under the influence of ultraviolet rays;
    kidneys - with the participation of parathyroid hormone, produced by parathyroid glands, turns into an active metabolite (a powerful renal hormone with a steroid structure);
    liver - after the hydroxylation reaction becomes 25-oxycholecalciferol.
Most of the vitamin D is excreted by bile. The half-life period is 19 days.

Thiamin is absorbed in the intestine by active transport into the epithelial cell with a specific carrier. In large quantities, vitamin B1 can also be absorbed by active diffusion. After 15 minutes it is already found in the blood plasma (the maximum concentration is reached after 1.5 hours), but only after half an hour in various tissues of the body. The vitamin B1 is deposited mainly in the brain, kidneys, adrenal glands, liver and heart, as these organs consume thiamine in the largest quantities. The active component of the pharmaceutical preparation is metabolized by the liver at an average rate of about 1 mg per day. The half-life period varies from 4 to 6 hours, depending on the individual indices of metabolic rate.
Vitamin B2 is absorbed in the gastrointestinal tract by active transport, after which it undergoes enterohepatic circulation, that is, getting into the vascular channel passes through the liver. The greatest amount of riboflavin after oral administration is observed in the heart muscle, liver, kidneys and brain. About 10 percent of the vitamin is excreted in the urine, the rest of the active ingredient undergoes a reverse absorption cycle in the tubule of the kidneys, and then returns to the main and peripheral blood flow.
Pyridoxine is absorbed by simple diffusion in the intestine. In the blood, it turns into pyridoxamine, after which the final product of 4-pyridoxyl acid exchange is formed without the participation of any biological catalysts. In tissues, vitamin B6 is phosphorylated to organic salts above this acid, which are excreted in the urine. The maximum concentration of vitamin is found in the liver and myocardium, the physiological depot of the active component of the drug Elevit Pronatal.
A little more than half of all vitamin E is absorbed from the intestine. The presence of fatty acids is required for its normal absorption. In the blood, tocopherol gets through the lymph, it contacts first with chylomicrons, and in plasma already with beta-lipoproteins. Accumulates tocopherol in the pituitary gland, testes and adrenal glands. The active ingredient is excreted more bile (approximately ¾ of the total dosage of the drug), and the rest is excreted in the urine in the form of conjugated glucuronides.
Cyanocobalamin is the only water-soluble vitamins of the Elevit Pronatal complex, which has a cumulation property. This creates an additional risk of overdose by the active ingredient. The cycle of absorption of vitamin B12 is particularly complex in view of the branched spatial configuration of the molecule. For its complete absorption requires the presence of physiological microflora of the digestive tract, two specific receptors and certain transmembrane vectors.

Indications for use

    hypovitaminosis;
    avitaminosis;
    insufficiency of minerals and microelements;
    preventive treatment of anemia due to deficiency of folic acid, cyanocobalamin or iron;
    correction of mineral metabolism and vitamins metabolism in pregnancy planning;
    period of pregnancy, after childbirth and breastfeeding.

Contraindications

    increased individual sensitivity, hereditary or acquired intolerance to the components of a pharmaceutical product;
    hypervitaminosis of any of the vitamins;
    increased calcium in the blood;
    impaired kidney or liver function;
    urolithiasis disease;
    nephrolithiasis and urolithiasis;
    hypermagnesia;
    hyperphosphataemia;
    increased release of calcium in the urine;
    violation of digestibility and iron utilization processes.

Side effects

As a rule, the pharmaceutical preparation is well tolerated, since the prevailing part of the constituent components of the drug are elements of the physiological metabolism of the human body. However, in clinical practice, there are side effects of a different nature. So, for example, can be observed:
    disruption of the functioning of the stomach-intestine system (discomfort in the epigastric region, bloating);
    nausea and vomiting;
    constipation or diarrhea;
    hemolytic anemia with deficiency of glucose-6-phosphate dehydrogenase;
    hypercalciuria;
    headache and dizziness;
    increased excitability;
    allergic reactions - urticaria, swelling, skin itching or rashes.
Separately, it should be noted possible side effects from the immune system of the body, since when they occur, you should immediately seek qualified medical help:
    anaphylactic reactions up to shock with appropriate laboratory and clinical manifestations (extremely rare);
    asthmatic syndrome;
    not cardiogenic pulmonary edema;
    manifestations of the cardiovascular system.
Before conducting a course of conservative treatment, patients should be warned about certain consequences of drug therapy that are not of clinical significance:
    it is possible to stain urine in intensely yellow color due to a large amount of vitamin B2;
    change in color of feces to black, due to increased concentration of iron.

Elevit Pronatal, instructions for use (Method and dosage)

Instruction on Elevit Pronatal says that it is extremely simple to use a medicine. For the correct reception of a pharmaceutical product, special skills or skills of medical personnel will not be required. You should consume vitamins orally, preferably in the morning, 15 minutes after breakfast. Elevit Pronatal it is necessary to drink a small amount of water.
For pregnant women, the dosage is 1 tablet daily. The course of conservative therapy is determined by the attending physician individually, as a rule, it is prolonged until the end of pregnancy in order to avoid any negative consequences. Therapy can be continued for the duration of breastfeeding, if there are appropriate indications from the mother.

Overdose

If during the course of the course of drug therapy clearly follow the instructions for the use of the drug, then the symptoms of overdose are extremely unlikely, since vitamin complexes can be stored and deposited in the body. However, with excessive use of the drug, hypervitaminosis of vitamins A or D may develop, which are accompanied by such clinical manifestations:
    nausea;
    vomiting;
    persistent, hard-to-lock constipation;
    severe headaches.
There is no specific pharmaceutical antidote for the state of increased concentration of these vitamins. Symptomatic therapy of each side effect is used separately.

Interaction

Vitamins Elevit Pronatal contains iron, calcium, copper and zinc, the oral use of which inhibits the absorption capacity of antibiotics of the tetracycline group and antiviral drugs. At absolute indications to use of both medicines it is recommended to do a time interval between receptions of medicines in two hours.
Antacid antiulcer pharmaceuticals reduce the absorption of the vitamin complex and trace elements, so it is necessary to observe an interval of three hours between the use of medicines.
With caution should be used Elevit in combination with anticoagulants or drugs that affect the system of clotting and platelet aggregation, because it is possible to develop a syndrome of increased coagulation and increase the viscosity of the blood, which is fraught with serious and even fatal consequences. If a course of conservative therapy prescribes the use of such drugs in the complex, regular diagnostic blood tests are recommended.
Treatment with laxative drugs increases the amount of excreted contents from the gastrointestinal tract, which adversely affects the pharmacokinetic ability of Elevit (fewer active ingredients have time to be absorbed from the surface of the digestive tube, which leads to a decrease in therapeutic effects.
Thiazide diuretics and calcium preparations when combined with their vitamin complex increase the risk of hypercalcemia and the deposition of salts of other microelements in the urinary tract, therefore, regular biochemical blood tests are recommended to detect the slightest signs of increased concentration of any fractions.
The simultaneous use of Elevit Pronatal with pharmaceuticals such as Levodopa, bisphosphonates, fluoroquinolones, penicillamine, thyroxin and digitalis medicines reduces their therapeutic effects. However, the mechanism from the interaction has not been established in the course of clinical studies, so combine them in the course of conservative treatment with caution.
The vitamin complex is also able to interact with food. So, for example, oxalic acid (found in large quantities in spinach and rhubarb) and phytic acid (a component of whole grains) inhibit the absorption of calcium. Therefore, before starting the medication, you should consult with a qualified specialist about the diet for the period of conservative therapy.

Storage conditions

Keep away from excessive moisture in a place inaccessible to young children and at a temperature of no higher than 25 degrees Celsius.
Shelf life - 2 years.

special instructions

Elevit Pronatal does not affect the ability to concentrate and small motor skills, therefore driving or other complex mechanisms during the course of conservative therapy is not prohibited.

Children

Clinically confirmed data on the use of the drug Elevit Pronatal in the pediatric practice is not, however, vitamin complexes are actively used to prevent diseases of young children.

With alcohol

The vitamin complex does not interact with the components of alcoholic beverages, however, in order to tolerate a healthy child, one should abandon such harmful habits as alcohol and smoking.

Elevit Pronatal for pregnant women (and during lactation)

Vitamins for pregnant women are an extremely important part of the drug prevention of various pathologies and premature births, but the instructions and the scheme for the use of the pharmaceutical preparation should be strictly followed, since adverse effects are possible.
For example, vitamin A in excess of 10,000 IU (international units) in the first trimester may have teratogenic properties. Therefore, it is not recommended to combine the medicinal products containing the synthetic isomer isotretinoin and etretinate or beta-carotene together with the vitamin complex.
Also, increased amounts of calciferol may be harmful (in the course of clinical studies it has been proven that excess vitamin D in animals leads to a teratogenic action of the nutrient), since hypercalcemia leads to a delay in the physical and mental development of the fetus, over valvular and aortic stenosis, the occurrence of retinopathies in child.
Separately, it should be said about vitamin D and breastfeeding, since the active component of the drug is able to penetrate into the mother's milk at excess concentrations in the body. The highest safe dose for a woman during lactation is 2 000 IU per day. 1 tablet Elevit Pronatal contains 500 IU of vitamin D.
Deficiency of vitamins and trace elements during child bearing can be avoided by using Elevit Pronatal in planning pregnancy. In this case, the scheme of application becomes less intense, and the dosage of the drug decreases, so as not to overload the organism of the future mother. The favorable therapeutic effect of this preventive treatment has been proven in clinical trials, because the physiological depots of useful nutrient components are pre-filled and consumed as needed.

Reviews about Elevit Pronatal

Reviews on Elevit Pronatal during the planning of pregnancy are uninterruptedly telling about the favorable therapeutic effect of the drug. First of all, doctors note that the process of fertilization is much more intensive with a sufficient number of all fractions of useful nutrients. Development of the fetus is not associated with the risks of various pathologies, as, for example, with a deficiency of vitamins. Microelements, in turn, are a stimulating factor for the proper laying of vital tissues and organs.
Among pregnant women, vitamins Elevit Pronatal are also very popular, reviews on different pharmaceutical forums only confirm this fact, because with the current lifestyle, inflation rate and other minor problems, maintaining a healthy diet is difficult, and it is very important for a developing child to receive all the necessary minerals and vitamins.
Reviews of pregnant women about the pharmaceutical preparation Elevit Pronatal are overshadowed only at the very beginning of conservative treatment, since the prevalent category of women faced a deficit condition immediately during the period of gestation. However, insufficiency is easily cured by drug therapy, which almost does not cause side effects or adverse consequences. In addition to the main therapeutic effects on the development of the fetus, the pharmaceutical drug has its effect on the mother's body. Due to active components, normal metabolic pathways are restored, laboratory indicators return to the physiological framework.
Separately, you should look at the reviews of gynecologists about this drug. After all, when planning pregnancy, these experts are watching the indicators of the female body and the right course of the period before and after fertilization. Of course, most qualified specialists officially express their approval, since it is much more favorable to prevent a possible problem than to treat its consequences proactively. The impetus for the development of some hereditary nosological units is the inadequacy of useful nutrients, which, in the preventative scheme of sanation, can be avoided by avoiding severe pathologies. However, do not look at the pharmaceutical drug as a wand-zashchalochku, in addition to conservative treatment, a pregnant woman, like only planning a future child, must necessarily maintain a healthy lifestyle and proper nutrition, abandon bad habits.