Foliber tabs #28

Instruction for Foliber

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Composition

The composition of one tablet Foliber includes:
    Folic acid (vitamin B9) - 400 mcg;
    cyanocobalamin (vitamin B12) - 2 mcg.
Also, the auxiliary components: magnesium stearate, lactose monohydrate, sodium carboxymethyl starch, trisodium citrate, microcrystalline cellulose, maltodextrin, citric acid.

Form of issue

Round or flat tablets of yellow color in the cell contour plates of 28 pieces. Packed in cardboard boxes.

pharmachologic effect

The drug Foliber helps to overcome the metabolic blockade, which is observed in embryos with a neural tube defect.
Vitamin B12 in this case is the key substance in the metabolism of the important amino acid methionine.
Inadequate amounts of folic acid in the body disrupt the synthesis of DNA in the cells. Folic acid is involved in cell division and the synthesis of nucleic acids.

Pharmacodynamics and pharmacokinetics

Folic acid is rapidly absorbed into the jejunum. Afterwards, she undergoes the methylation process to 5-methyltetrahydrofolate. The maximum concentration in the serum (Cmax) is reached after 30 - 60 minutes.
In turn, vitamin B12 interacts with substances that stimulate hematopoiesis (hemopoiesis). Cmax in this case is achieved in plasma after 8-12 hours.
Folic acid and vitamin B12 undergo significant recycling in the gastrointestinal tract.

Indications for use

Prevention of deficiency of vitamin B12 (cyanocobalamin) and folic acid.
The drug is intended primarily for women of childbearing age who plan pregnancy. It is advisable to begin using at least 1 month before conception. Then 1 trimester during pregnancy to stabilize the development of the neural tube in children in the first weeks of life.

Contraindications

Individual hypersensitivity to the ingredients of the drug.
Foliber contains 23 mg of lactose in one tablet. This need to pay attention to patients with a violation of absorption of galactose and glucose, as well as with lactase deficiency or with symptoms of galactosemia (a violation of the process of transformation of galactose into glucose)

Side effects

There is the possibility of an allergic reaction.

Instructions for the use of Folifer (Method and dosage)

The drug Foliber is applied on 1 tablet once a day before a meal.

Overdose

Cases of overdose were not observed.

Interaction

Do not use Foliber in combination with Methotrexate, because it acts as an antagonist of folic acid and reduces the rate of chemical reactions of the enzyme hydrophosphate reductase.
The use of the drug together with the anti-epileptic groups of hydantoin inhibits and significantly reduces the effect of the latter.

Terms of sale

The drug Foliber is released as a medicine without issuing a prescription.

Storage conditions

Folder should be stored in a dry place, limited to children. Storage temperature should not exceed 25 ° C.
Shelf life - two years.

special instructions

The drug does not affect the ability to drive vehicles or work with mechanisms.

Foliber in Pregnancy

This drug is intended to compensate for the deficiency of B vitamins in the human body. The main substances of Foliber are folic acid and vitamin B12, which are important components for maintaining a normal current pregnancy. With a deficiency of vitamins, the drug is necessary for successful influence on the development of the tissues of the child. The lack of vitamins can lead to a defect in the neural tube, in this case, Foliber is needed as a preventive measure even in the planning of pregnancy.
The drug is not just a vitamin, but a complex substance that contains the minimum amount of a daily dose (use of the drug is indicated in the instructions for Foliber).
Fiber in pregnancy can also stimulate the system of blood supply.

Reviews about Foliber

Although Foliber is a relatively young drug, he found positive recommendations among medical professionals. Previously, pregnant women or those who were planning to conceive were prescribed simply folic acid or individual injections of vitamin B12. To date, we have a complex preparation that combines both components. A single daily dose of the drug includes sufficient availability of folic acid and vitamins B. In this case, multiple separate intake of ingredients during the day is excluded.
About individual application, associated with changing dosages, it is necessary to consult with an observant physician. Reviews about Foliber are positive.