Vitamin E caps 400mg #30

Vitamin E instruction

You can buy Vitamin E here

Composition

1 capsule contains vitamin E (tocopherol acetate) 100 mg, 200 mg or 400 mg
Excipients: sunflower oil, gelatin, glycerol 75%, methylparaben, Crimson rubor rubor ponceau 4R (E 124), purified water.

Description

Red, oval capsules filled with a transparent light yellow oil.

Pharmacotherapeutic group

vitamins
ATX Code: A11HA03

Pharmacological properties

It has an antioxidant effect, participates in the biosynthesis of heme and proteins, cell proliferation, tissue respiration, other important processes of tissue metabolism, prevents hemolysis of erythrocytes, reduces the increased permeability and fragility of capillaries. It is necessary for the development and functioning of connective tissue, smooth and skeletal muscles, and also for strengthening the walls of blood vessels. Participates in the metabolism of nucleic acids and prostaglandins, cellular respiratory cycle, in the synthesis of arachidonic acid. It is a natural antioxidant, inhibits peroxide oxidation of lipids by free radicals. Activates phagocytosis and is used to maintain normal erythrocyte resistance. In large doses, it prevents the aggregation of platelets. Has a pronounced positive effect on the human reproductive system, slows the development of atherosclerotic changes in blood vessels.

Pharmacokinetics

When ingested absorbed 20% -40% (necessary presence of bile and normal functioning of the pancreas). When the dose is raised, the degree of absorption decreases. The optimal concentration in the blood is 10-15 mg / l. Excretion mainly with feces.
Less than 1% is excreted in the urine in the form of glucuronides and other metabolites.

Indications for use of Vitamin E

prevention and treatment of Vitamin E hypovitaminosis;
in complex therapy for hormonal treatment of menstrual disorders, degenerative and proliferative changes in the joints and ligamentous apparatus of the spine, in muscular dystrophy, with amyotrophic lateral sclerosis;
condition of convalescence after the transferred diseases;
inadequate and unbalanced nutrition
increased physical activity.

Contraindications for Vitamin E

Hypersensitivity to the components of the drug, acute myocardial infarction, children's age.
With caution - in patients with severe cardiosclerosis, myocardial infarction, with an increased risk of thromboembolism; hypoprothrombinemia caused by vitamin K deficiency may worsen when vitamin E is administered at a dose greater than 400 IU.

Application during pregnancy and breastfeeding.

During pregnancy and breastfeeding, take the drug only on the advice of a doctor.

Dosing and Administration

Capsules 100 mg: adults 2-4 capsules per day.
Capsules 200 mg: adults 1-2 capsules per day.
Capsules 400 mg: adults 1 capsule per day.
For menstrual disorders (as an adjunct to hormonal therapy) 300-400 mg every other day, starting from the 17th day of the cycle.

Side effect

Allergic reactions; from the gastrointestinal tract: diarrhea, nausea, gastralgia. It is rare in patients with predisposition to develop creatinuria, increased activity of creatine kinase, increased serum cholesterol levels, thrombophlebitis, thromboembolism of the lungs, thrombosis.

Overdose

High doses of vitamin E (400-800 mg per day for a long time) can cause visual disturbances, diarrhea, dizziness, headache, nausea, severe fatigue, fainting, white hair growth in areas of alopecia with bubble epidermolysis.
Very high doses (exceeding 800 mg for a long time) can cause bleeding in patients with vitamin K deficiency; they can disrupt the metabolism of thyroid hormones and increase the risk of thrombophlebitis and thromboembolism in sensitive patients.
Treatment: symptomatic, withdrawal of the drug.

Interaction with other drugs

Enhances the effect of glucocorticosteroids, non-steroidal anti-inflammatory drugs, cardiac glycosides. Increases the effectiveness of antiepileptic drugs in patients with epilepsy (who have increased blood levels of lipid peroxidation products).
Iron increases the daily requirement for vitamin E. Vitamin E increases the effect of anticoagulants, if the dose exceeds 400 IU per day.
It is not recommended to simultaneously take other vitamin complexes containing vitamin E, in order to avoid a pre-infection.
The appointment of vitamin E in high doses can cause vitamin A deficiency in the body.
Simultaneous use of vitamin E at a dose of more than 400 IU per day with anticoagulants (coumarin and indanedione derivatives) increases the risk of development of hypothrombinemia and bleeding.
Colestramine, colestipol, mineral oils reduce absorption.

special instructions

With congenital bullous epidermolysis in areas affected by alopecia, white hair may begin to grow.

Form of issue

Capsules 100 mg, 200 mg: 30 capsules in bottles of dark glass.
Capsules 400 mg: 20 or 30 capsules in bottles of dark glass.
Each bottle, along with instructions for medical use, is placed in a cardboard box.

Storage conditions

At a temperature of 15 to 25 ° C in a dry, dark place.
Keep out of the reach of children.
Shelf life - 3 years.
Do not use after the expiration date printed on the package.

Vacation from pharmacies

To buy Vitamin E the prescription is not required.