Zincteral tabs 0.124gr #25

User manual for Zincteral

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Composition

One tablet of the preparation contains: zinc sulfate heptahydrate (in terms of zinc sulfate monohydrate) - 124 mg, which corresponds to 45 mg of zinc ions.
Auxiliary substances: potato starch, povidone, talc, magnesium stearate, lactose monohydrate.
Sheath composition: macrogol (polyoxyethylene glycol), hypromellose (hydroxypropylmethylcellulose), titanium dioxide, azorubic varnish.

Form of issue

Biconvex tablets covered with a coat of pink-violet color, rounded.
25 such tablets in a blister, one such blister in a cardboard bundle; or 150 such tablets in a polymer bank, one such bank in a cardboard bundle.

pharmachologic effect

The drug has an effect similar to vitamins - replenishment of micronutrient deficiency (zinc), stimulation of metabolic processes.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Zinc is one of the most important trace elements, present in many protein complexes that regulate the central metabolic processes, namely, the synthesis of proteins and the metabolism of carbohydrates. Zinc is indispensable for the proper functioning of more than 200 metalloenzymes (for example, carboxypeptidase A, alcohol dehydrogenase, carbonic anhydrase, alkaline phosphatase, RNA polymerase, etc.) and to maintain the proper structure of proteins, nucleic acids and cell membranes.
Zinc also promotes the development and growth of cells, the proper functioning of the immune system and immune response, the provision of twilight vision, taste sensations and odor perception. It influences the preservation of an acceptable level of vitamin A in the blood serum, prolongs the action of insulin and simplifies its accumulation. In inflammatory skin diseases produces a preventive and therapeutic effect.
The lack of zinc causes difficulties in concentration and memory, impaired appetite and distorted taste, decreased humoral and cellular immunity, slow wound healing, night blindness, hypercholesterolemia, pathology of carbohydrate metabolism, hypertension, cerebral and psychiatric disorders, prostatic hypertrophy, pregnancy pathology, hypogonadism and slower growth in children and to a greater extent - skin disorders (some types of alopecia, acne). In excessive doses, zinc inhibits the adsorption of copper. The deficiency of zinc enhances the absorption of harmful cadmium.

Pharmacokinetics

Regardless of the zinc concentration in food, about 25-30% of the zinc used in the small and duodenal ulcers adsorbs. The maximum content of zinc in the blood is reached 2 hours after the drug is used. Zinc in the body accumulates mainly in erythrocytes and leukocytes, as well as in bones, muscles, kidneys, liver, skin, prostate and pancreas, and the retina. 60% of the element interacts with albumins, 35-40% with alpha-macroglobulin, 1% with some amino acids (histidine, cysteine). It is excreted mainly through the intestine (90%), the rest - with sweat and urine.

Indications for use of Zincteral

    Complex therapy of diseases leading to the development of zinc deficiency.
    Enteropathic acrodermatitis.
    Neurotic alopecia, malignant alopecia.
    Pustular and purulent acne.
    With a long-term intake of corticosteroids, at the time of cancellation.
    As an additional treatment for slowly healing wounds.

Contraindications

Hypersensitivity to any of the components of the drug.
Cautions: long-term use of zinc preparations should take into account the risk of developing copper deficiency; It is forbidden to drink alcohol during the period of treatment with the drug.

Side effects

Can be noted:
    nausea, heartburn, diarrhea;
    leukopenia accompanied by influenza-like syndrome;
    sideroblastic anemia and general weakness, decreased copper in the blood;
    rarely there may be headaches and metallic smack.

Instructions for Zincteral

Instructions for use Zincteral indicates how to take this medication: orally, without chewing during or after a meal.
    With nest alopecia, enteropathic acrodermatitis: children from 4 years and adults - 1 tablet three times a day. After the onset of clinical improvement, the dosage is reduced to 1 tablet twice a day, then 1 tablet a day until the symptoms disappear.
    With malignant alopecia: adults are prescribed 1-2 tablets three times a day; children from 4 years - 1 tablet three times a day.
    From acne (purulent and pustular acne): adults - 1-2 tablets once a day, children from 4 years -1 tablet a day.
    With zinc deficiency: adults -1 tablet three times a day, after the disappearance of symptoms you can drink 1 tablet a day; children from 4 years - 1 tablet a day.

Overdose

Overdose can manifest as burning sensation in the mouth and throat, bloody or watery diarrhea, belching, dizziness, jaundice, pulmonary edema (difficulty breathing, pain in the sternum), hematuria, vomiting, convulsions, collapse, anuria, hemolysis.
In case of appearance of the above symptoms, it is necessary to drink water or milk, and then inject intravenously or intramuscularly the calcium dihydrate salt of ethylenediaminetetramine acetic acid at a dose of 55-75 mg / kg of body weight per day (divided into 3-6 injections) for not more than five days. Do not induce vomiting or rinse the stomach.

Interaction

Tetracyclines and preparations of copper. The drug reduces the absorption of tetracyclines and slows the absorption of copper (when using large doses of zinc), so Zincteral should be used 2 hours after taking tetracyclines and copper preparations.
Thiazide diuretics accelerate the excretion of zinc by the kidneys.
A diet that contains a lot of fibrin (bran), phosphates (dairy products), whole grain bread products, weakens the adsorption of zinc, so Zincteral should be used 2 hours after eating rich foods.
Folic acid also slightly reduces zinc absorption.
High doses of iron for ingestion suppress zinc absorption (exposure between the doses of these drugs should be at least two hours)
Penicillamine and other chelating agents reduce the adsorption of zinc (exposure between the methods of these drugs should be at least two hours).
When using vitamin preparations with Zincteral, which contain zinc, it is necessary to remember the possibility of developing symptoms of an overdose.
Quinolones. Tsinkteralom reduces the adsorption of quinolone-containing antibacterial drugs and fluoroquinolones.

Storage conditions

The drug should be stored at a temperature of 15-20 ° C in a place inaccessible to children, dry place.
Do not use after the expiration date.
Shelf life - 3 years.

special instructions

Zincteral contains lactose in the composition, so it is contraindicated in patients with lactose deficiency, intolerance to galactose, or impaired glucose and galactose adsorption.

Children

Admission to children from 4 years is allowed.

In pregnancy and lactation

Zinc is able to penetrate the placenta. In pregnancy, the drug is used only in cases where the benefit to the mother exceeds the possible risk to the fetus.
Zinc excreted in breast milk. Therefore, you should refrain from taking the drug during lactation.

Reviews of Zincteral

Tablets Zincteral have a fairly large list of indications, so you can hear a wide range of comments on its use. When used as a hair remedy, reviews about Zincteral are good enough, when used as a remedy for acne, reviews about Zincteral are even better.
The drug is also used in bodybuilding and in men to increase testosterone production and stimulation of spermatogenesis, but these effects are not proven.
Reviews of doctors about Zincteral often indicate a fairly large number of emerging side effects, especially from the digestive tract.