Lincomycin hydrochloride caps 250mg #20

Lincomycin hydrochloride user manual

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Composition

As part of the antibiotic, there is an active substance linkomycin and additional substances: sodium hydroxide, disodium edetate, water.

Form of issue

Lincomycin hydrochloride is available as a solution for injection. It is a liquid without color, with a slight specific smell, transparent or having a light yellowish hue. Ampoules with a solution are packed in boxes of cardboard for 5 or 10 pieces.

pharmachologic effect

Lincomycin hydrochloride is an antibiotic from the group of lincosamides. When using therapeutic doses of this drug, it has a bacteriostatic effect on the body. The use of higher concentrations of the active ingredient provides a bactericidal effect. Antibiotic suppresses the processes of protein synthesis in cells of pathogenic microorganisms. In general, the active ingredient exhibits activity relative to gram-positive bacteria. Resistance to lincomycin is in most of the Gram-negative bacteria, viruses, fungi, protozoa. Resistance is produced relatively slowly.
There is a cross-resistance of microflora to clindamycin, lincomycin, as well as to other antibacterial agents that belong to the group of lincosamides.

Pharmacokinetics and pharmacodynamics

The active substance is absorbed into the digestive tract well, its greatest concentration in the blood is noted after 0.5-1 hour after intramuscular injection. With blood proteins binds to 72%. Penetrates through the placenta and is detected in breast milk. Badly passes through the blood-brain barrier. Partly the substance is metabolized in the liver. Its half-life is approximately 5 hours. It is excreted from the body both unchanged and metabolites.
It is excreted from the body through the kidneys, as well as with feces and bile. After intramuscular injection, the therapeutic concentration in the blood of lincomycin is maintained for 17-20 hours if the drug is administered intravenously - then for 14 hours.

Indications for use

The use of Lincomycin hydrochloride is indicated in such diseases:
    septic processes (the presence of pathological microorganisms in the blood);
    osteomyelitis (inflammatory processes of bone tissue and bone marrow);
    Staphylococcal infections;
    diseases of an infectious-inflammatory nature, which were provoked by pathogens showing sensitivity to lincomycin.

Contraindications

You can not take Lincomycin hydrochloride at a high sensitivity to lincomycin and clindamycin. The drug is not prescribed to people who have a serious impairment of kidney or liver function. Do not prescribe to pregnant women, women during the period of feeding, infants of early infancy.

Side effects

In the process of treatment, the agent may manifest such side effects:
    The digestive system: diarrhea, vomiting, nausea, abdominal pain, stomatitis, glossitis.
    The system of hematopoiesis: neutropenia, reversible leukopenia, thrombocytopenia.
    Allergic manifestations: dermatitis, urticaria, anaphylactic shock, Quincke's edema.
    Candidiasis.
If the drug is administered intravenously, phlebitis may appear as a local reaction.
In the case of rapid intravenous administration, the patient may lower blood pressure, manifest general weakness and dizziness, relaxation of the musculature of the skeleton.
Long-term treatment with large doses of the drug can lead to the manifestation of pseudomembranous colitis.
Instructions for use (Method and dosage)
If Lincomycin hydrochloride has been assigned to a patient, instructions for use during treatment should be observed.
The instruction for Lincomycin hydrochloride in ampoules provides for the possibility of intravenous and intramuscular administration of the agent.
When the drug is administered intramuscularly, adult patients receive 600 mg per day, the administration is 1-2 times.
Intravenous drip introduction, with 600 mg of the agent is dissolved in 250 ml of glucose or isotonic sodium chloride solution, the administration can be carried out 2-3 times a day.
Children who are already 1 month old, with the development of severe infectious diseases, are given an intramuscular injection of the drug, the dosage is determined as follows: for 1 kg of body weight, 10 mg of the drug. The drug is administered every 12 hours. It is possible to administer intravenously, the dose at the same time is 10-20 mg / kg per day.

Overdose

If an overdose of Lincomycin hydrochloride occurs, those symptoms that are described as side effects from the digestive system - diarrhea, nausea, vomiting - may appear. If there is a rapid introduction of a non-diluted drug, there is a possibility of cardiac arrest. There are no specific antidotes, symptomatic treatment is performed.

Interaction

If the drug is administered simultaneously with cephalosporins, penicillins, chloramphenicol, erythromycin, antagonism of antimicrobial effects may be noted.
Simultaneous reception with aminoglycosides can provoke synergism of the action.
If Lincomycin hydrochloride is taken at one time and preparations for inhalation anesthesia or muscle relaxants of peripheral action are used, neuromuscular blockade may increase, apnea may develop.
With simultaneous treatment with antidiarrhoeic agents, a decrease in the effect of lincomycin is noted.
The drug is incompatible with barbiturates, ampicillin, calcium gluconate, heparin, theophylline, magnesium sulfate.
In one syringe or dropper it is impossible to combine Lincomycin hydrochloride and Novobiocin and Kanamycin.

Storage conditions

It should be protected from children, stored in a dark place at an air temperature not exceeding 25 ° C.
Shelf life - 3 years.

special instructions

If the patient has a violation in the functions of the liver, kidneys, you need to reduce the dosage or increase the period between administration of the drug. If the remedy is used for a long period, the functions of the liver, kidneys, and laboratory blood counts should be systematically monitored.
Carefully prescribe a drug to treat people with a tendency to allergies, patients with colitis, bronchial asthma, as well as those who have a history of GI disease.
If a patient develops pseudomembranous colitis, it is necessary to cancel taking the drug.

Children

It can be used in the presence of indications for the treatment of children aged 1 month. It is used only for the purpose of a specialist.

In pregnancy and lactation

Since lincomycin is able to penetrate the placental barrier, and it is excreted in breast milk, it should not be used for the treatment of pregnant women and nursing mothers.

Reviews

In the network, users leave in most cases positive feedback about this drug. In particular, the use of Lincomycin hydrochloride in dentistry, in infectious diseases with severe course is positively assessed. It is noted that this antibiotic very effectively eliminates symptoms and speeds up the process of recovery.