Lincomycin ointment 2% 15gr

Lincomycin ointment instruction for use

You can buy Lincomycin ointment here

pharmachologic effect

Antibiotic group of lincosamides. In therapeutic doses, it acts bacteriostatic. At higher concentrations has a bactericidal effect. Suppresses protein synthesis in the microbial cell.
Active mainly against aerobic gram-positive bacteria: Staphylococcus spp. (including penicillinase producing strains), Streptococcus spp. (including Streptococcus pneumoniae / with the exception of Enterococcus faecalis /), Corynebacterium diphtheriae; anaerobic bacteria Clostridium spp., Bacteroides spp.
Lincomycin ointment is also active against Mycoplasma spp.
Most gram-negative bacteria, fungi, viruses, protozoa are resistant to lincomycin ointment. Stability is developed slowly.
There is cross-resistance between lincomycin and clindamycin.

Pharmacokinetics

After ingestion, 30-40% is absorbed from the gastrointestinal tract. Eating slows down the speed and extent of absorption. Lincomycin ointment is widely distributed in tissues (including bone) and body fluids. It penetrates the placental barrier. Partially metabolized in the liver. T1 / 2 is about 5 hours. It is displayed in unchanged form and in the form of metabolites with urine, bile and feces.

Indications for Lincomycin ointment

Infectious and inflammatory diseases of the severe course caused by microorganisms sensitive to lincomycin ointment, including sepsis, osteomyelitis, septic endocarditis, pneumonia, lung abscess, pleural empyema, wound infection. As an antibiotic reserve for infections caused by staphylococcal strains and other gram-positive microorganisms resistant to penicillin and other antibiotics.
For external use: purulent-inflammatory diseases of the skin.

Contraindications

Severe abnormal liver and / or kidney function, pregnancy, lactation, hypersensitivity to lincomycin and clindamycin.

Dosage

When administered to adults - 500 mg 3-4 times / day or i / m - 600 mg 1-2 times / day. In / drip injected 600 mg in 250 ml of isotonic sodium chloride or glucose 2-3 times / day.
Children aged from 1 month to 14 years inside - 30-60 mg / kg / day; IV drip is administered at a dose of 10–20 mg / kg every 8–12 h.
When applied topically, apply a thin layer on the affected skin.

Side effects of Lincomycin ointment

On the part of the digestive system: nausea, vomiting, epigastric pain, diarrhea, glossitis, stomatitis; transient increase in liver transaminases and plasma bilirubin; with prolonged use in high doses, pseudomembranous colitis may develop.
On the part of the blood system: reversible leukopenia, neutropenia, thrombocytopenia.
Allergic reactions: urticaria, exfoliative dermatitis, angioedema, anaphylactic shock.
Effects due to chemotherapeutic action: candidiasis.
Local reactions: phlebitis (with a / in the introduction).
With the rapid on / in the introduction: a decrease in blood pressure, dizziness, weakness, relaxation of skeletal muscles.

Drug interaction

With simultaneous use with penicillins, cephalosporins, chloramphenicol or erythromycin antagonism of antimicrobial action is possible.
With simultaneous use with aminoglycosides, synergism of action is possible.
With simultaneous use with agents for inhalation anesthesia or muscle relaxants of peripheral action, an increased neuromuscular blockade is observed, up to the development of apnea.
Taking antidiarrheal drugs reduces the effect of lincomycin ointment.

Pharmaceutical Interaction

Pharmaceutically incompatible with ampicillin, barbiturates, theophylline, calcium gluconate, heparin and magnesium sulfate.
Lincomycin ointment is incompatible in the same syringe or dropper with kanamycin or novobiocin.

special instructions

In case of impaired liver and / or kidney function, a single dose of lincomycin should be reduced by 1 / 3-1 / 2 and the interval between injections should be increased. With prolonged use requires systematic monitoring of the functions of the kidneys and liver.
If pseudomembranous colitis develops, lincomycin ointment should be canceled and vancomycin or bacitracin should be prescribed.

Pregnancy and lactation

Lincomycin ointment crosses the placental barrier, is excreted in breast milk. Use during pregnancy is contraindicated. If necessary, use during lactation should decide on the termination of breastfeeding.

Use in childhood

Children aged from 1 month to 14 years inside - 30-60 mg / kg / day; IV drip is administered at a dose of 10–20 mg / kg every 8–12 h.

In case of impaired renal function

Contraindicated in severe renal impairment.
In case of impaired renal function, a single dose of lincomycin ointment should be reduced by 1/3 - 1/2 and the interval between injections should be increased. With prolonged use requires systematic monitoring of renal function.

With abnormal liver function

Contraindicated in marked disorders of the liver.
In case of abnormal liver function, a single dose of lincomycin ointment should be reduced by 1/3 - 1/2 and the interval between injections should be increased. With prolonged use requires systematic monitoring of liver function.

Terms of sell

To buy Lincomycin ointment the prescription is not required.