Norfloxacin 400mg #20

Norfloxacin instruction

You can buy Norfloxacin on this

Composition

1 tablet contains 200 or 400 mg of active substance. Additional components: lactose monohydrate, croscarmellose sodium, water, povidone, microcrystalline cellulose, magnesium stearate.

Form of issue

Produced in tablet form, in the form of drops for the eyes, ears.

pharmachologic effect

Antibacterial drug, fluoroquinolone.

Pharmacodynamics and pharmacokinetics

Has a bactericidal effect, leads to the death of bacteria and destabilization of the DNA chain. The drug Norfloxacin has a wide range of antimicrobial effects. The effective effect of the drug lasts 12 hours.

Indications for use

Norfloxacin is prescribed for bacterial infections of the urinary system (urethritis, cystitis, pyelonephritis), genital organs (endometritis, cervicitis, prostatitis), gastrointestinal tract (shigellosis, salmonellosis), uncomplicated gonorrhea, and travelers' diarrhea. It is used to prevent infectious diseases in patients with granulocytopenia.
Locally, Norfloxacin is administered with conjunctivitis, keratitis, keratoconjunctivitis, corneal ulcer, blepharitis, blepharoconjunctivitis, meibomite, dacryocystitis. The drug is used to prevent eye infections after extraction from the cornea of ​​a foreign body or conjunctiva, before and after surgical operations on the eyes, after damage by chemical substances.
Norfloxacin is effective for external otitis media, medium acute otitis media, chronic otitis media, and is prescribed to prevent complications of an infectious nature during surgical interventions on the hearing organ.

Contraindications

Norfloxacin is not prescribed for intolerance to fluoroquinolones, pregnancy, breastfeeding, lack of glucose-6-phosphate dehydrogenase, children and adolescents (under 18 years of age).
With caution apply for atherosclerosis of cerebral vessels, epileptic syndrome, renal failure, hepatic system, epilepsy.

Side effects

Digestive system: nausea, bitterness in the mouth, diarrhea, decreased appetite, epigastric pain, increased activity of "liver" transaminases, vomiting, dyspeptic disorders; with prolonged use develops pseudomembranous enterocolitis.
Urinary system: glomerulonephritis, albuminuria, crystalluria, polyuria, dysuria, hypercreatininaemia, urethral bleeding.
Nervous system: dizziness, headache, syncope, hallucinations, insomnia. Cardiovascular system: arrhythmia, vasculitis, a drop in blood pressure, tachycardia.
Organs of senses (with local use): photophobia, chemosis, conjunctival hyperemia, pain and burning in the eye, impaired vision.
Musculoskeletal: tendon ruptures, tendinitis, arthralgia.
Organs of hematopoiesis: a decrease in hematocrit, a decrease in the number of leukocytes, eosinophilia.
Allergic reactions are possible: edema, itching, Stevens-Johnson syndrome (exudative erythema of a malignant nature), urticaria. On other organs and systems - candidiasis.

Instructions for Norfloxacin (Method and Dosage)

Norfloxacin tablets, instructions for use

Inside: with cystitis without complications - 400 mg twice a day for 7-10 days; with infectious diseases of the urinary tract - within 3-7 days; with a urinary tract infection of a chronic recurrent nature - up to 12 weeks.
With acute gastroenteritis of bacterial type - 5 days; with pharyngitis, cervicitis, proctitis, acute gonococcal urethritis - 800 mg once; with typhoid fever - 400 mg of the drug three times a day for 14 days.
As a preventive agent: against sepsis - 400 mg twice a day; against bacterial gastroenteritis - 400 mg once a day; against travelers' diarrhea - 400 mg of the drug the day before departure and throughout the journey (no more than 21 days); against recurrences of infectious diseases of the urinary system - 200 mg of Norfloxacin per day.
In patients with impaired renal function with QC greater than 20 ml per minute, dosage adjustment is not required.
Patients on hemodialysis, and also with QC less than 20 ml per minute (or a serum creatinine level above 5 mg per 100 ml) are prescribed half the therapeutic dose twice a day or a full dose once a day.

Overdose

When you take 3 g for 45 minutes, nausea, vomiting, "cold" sweat, dizziness, puffy face develops in the absence of distortions of the basic hemodynamic parameters, drowsiness.
There is no specific antidote.
Treatment: emergency gastric lavage, the use of adequate hydration therapy with forced diuresis. A medical examination is required and for several days in-patient monitoring.

Interaction

Norfloxacin reduces the clearance of theophylline by 25%. Increases the level of concentration of cyclosporine and indirect anticoagulants in blood serum. Reduces the effect of nitrofurans.
Simultaneous use of antacids with magnesium and aluminum hydroxide, as well as drugs with sucralfate, negatively affects the absorption of Norfloxacin - between the intake of these drugs should be at least 4 hours apart.
Simultaneous reception of Norfloxacin with a lowering of the epileptic threshold of drugs can provoke the development of seizures of an epileptic form.
The simultaneous use of Norfloxacin and drugs, which are potentially capable of lowering blood pressure, can lead to a sharp decrease in blood pressure. Therefore, in such cases, as well as with the simultaneous use of barbiturate-containing and other drugs for general anesthesia, it is necessary to control the pulse, the level of blood pressure, the work of the heart.

Storage conditions

In a place inaccessible to children at a temperature of no more than 25 degrees Celsius.
The open solution should not be stored for more than 10 days.

Shelf life

Not more than two years.

special instructions

During the treatment with Norfloxacin, direct exposure to sunlight should be avoided, and a large amount of liquid should be taken. Special care must be taken when driving vehicles, managing complex mechanisms, performing work that requires high concentration of attention and operational psychomotor reactions (especially when ethanol is taken at the same time).
During therapy, an increase in the prothrombin index may be observed; When surgical intervention is necessary to constantly monitor the level of blood clotting.

Reviews about Norfloxacin

The drug is effective in infections that are sensitive to this drug. Before use, be sure to know with what microorganisms the drug can cope. Drops are effective in the treatment of conjunctivitis, keratitis, blepharitis, otitis.
From negative reviews about Norfloxacin, mention can be made of side effects of the medication, such as: depressive disorders, itchy skin, facial swelling, irritability.