Singlon tabs 10mg #28

Singlon user manual

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Composition

In 1 chewable tablet of Montelukast sodium, 5.20 mg. Mannitol, MCC, flavor, croscarmellose sodium, aspartame, dye, magnesium stearate, as auxiliary substances.
In 1 tablet in the shell of Montelukast sodium 10.4 mg.

Form of issue

Tablets in a shell of 10 mg.
Chewable tablets 4 mg and 5 mg.

pharmachologic effect

Anti-bronchoconstrictive, anti-inflammatory.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The active substance is a blocker of leukotriene receptors (individual leukotrienes are inflammatory mediators that support the bronchial hyperreactivity in asthma). Reception of the drug prevents excessive secretion in the lumen of the bronchi and swelling of the mucosa. Reduces the severity of bronchial asthma, the frequency of seizures.
Bronchodilator effect is observed within 24 hours. Effective in patients with mild bronchial asthma, which is poorly controlled by the intake of certain bronchodilators.

Pharmacokinetics

When ingested completely absorbed and after 2-3 hours in the blood determines the maximum concentration of the active substance. Bioavailability is 65-74%. 99% contact with blood proteins. Metabolised in the liver. It is excreted with bile.

Indications for use

    treatment of bronchial asthma;
    prevention of exacerbations of asthma;
    prevention of bronchospasm with physical effort;
    a combination of bronchial asthma with polyposis of the nose and intolerance to ASA;
    allergic rhinitis.

Contraindications

    impaired liver function;
    hypersensitivity;
    phenylketonuria (due to the content of aspartame).
Apply strictly in dosage according to age.

Side effects

    headache;
    stomach pain;
    dry mouth, thirst;
    nausea and vomiting;
    tendency to bruising and bleeding;
    hypersensitivity reactions;
    sleep disturbances, nightmares;
    insomnia;
    psychomotor hyperactivity;
    dizziness;
    convulsions;
    cardiopalmus;
    hepatitis, pancreatitis;
    hives;
    rash;
    arthralgia, myalgia.

Singlon, instructions for use (Method and dosage)

Chewing tablets Singlon 4 mg is recommended for children 2-5 years - 1 tablet in the evening, 1 hour before meals, every day in the evening.
Children aged 6-14 years are prescribed Singlon 5 mg - 1 tablet daily in the evening. The effect develops within a day. If the drug is prescribed in parallel with the GCS, then you can not dramatically replace them with this drug.
Singlon 10 mg is intended for adults and children from 15 years of age. It is recommended to take one tablet inside, regardless of the time of eating, every evening.

Overdose

Cases of overdose are not registered. In clinical studies, patients were taken at a dose of up to 200 mg / day for a long time (22 weeks) without significant events. There were cases of overdose when taking more than 1000 mg.
Adverse manifestations in this case included drowsiness, thirst, vomiting, abdominal pain, headache, mydriasis and hyperactivity.

Interaction

Possible reception with other drugs used to treat asthma. The recommended dose does not have significant effects on the kinetics of theophylline, prednisolone, terfenadine, oral contraceptives, digoxin and warfarin. When taking phenobarbital, the plasma concentration of the active substance decreases by 40%. Use caution when used concomitantly with phenobarbital, phenytoin and rifampicin (CYP 3A4 inducers).
Montelukast does not affect the metabolism of paclitaxel, repaglinide and rosiglitazone. Do not take the drug with other medications containing Montelukast.

Terms of sale

You don't need a prescription to buy Singlon online at our store.

Storage conditions

Temperature up to 25 ° С.
Shelf life - 3 years.

Reviews of Singlon

It must be remembered that this drug is not intended for relief of asthma attacks. To do this, there are other medicines. According to the reviews of patients suffering from asthma and who started taking Singlon on the background of taking glucocorticosteroids, it became possible to lower the dose of the latter. However, her decline occurred gradually and under the supervision of a doctor.
Tablets Singlon have a different dosage and are intended for adults and children of different ages. Safety of tablets for children under 2 years is not established. Singling is recommended for children in the form of chewable tablets, which is convenient for this age category. The use of this drug in children is an alternative to taking low-dose corticosteroids in the treatment of asthma only mild (it can be used as a monotherapy). But as a means of monotherapy is not recommended in patients with asthma of moderate severity.
The drug was prescribed to children not only with AD, but also with allergic rhinitis, frequent bronchitis with a tendency to bronchial obstruction. Here are some testimonials.
    "... We allergist appointed, very helped. Became much less sick and without obstructive bronchitis. "
    "... The son has bronchial asthma. Singlon reduced the number of attacks. "
    "... Drinking this drug 3 courses for 4 months. Helped and a week later the attacks stopped, but after the reception in 2 weeks everything returned, but in a lighter form. "
    "... The son has asthma. Drank the drug for 4 months. He does not save us from hormones. Attacks occur with each ARI. "
    "... The attacks went almost completely, the daughter takes it from April to October the third year."
    "... We take courses for 3 months in the autumn, during the period of colds. It helps. "
    "... Allergologist has appointed, we drink only 2 weeks and the night cough has passed, before this cough at night worried constantly during 2 years".
In most cases, the drug was well tolerated.