Montelucast tabs 10mg #30

Montelucast instruction for use

Reed more and buy Montelucast here

Chemical properties

Montelucast is a bronchodilator, an antileukotriene drug. In medicines is in the form of Montelucast sodium - white or white with a yellow hue hygroscopic powder. The substance is readily soluble in methyl alcohol, ethanol, water, and practically insoluble in acetonitrile. Molecular weight of compound = 608.2 grams per mole. The preparation is produced in the form of chewable tablets and tablets for oral administration.

pharmachologic effect

Bronchodilator.

Pharmacodynamics and pharmacokinetics

The drug belongs to the class of selective blockers of leukotriene receptors. The agent has an effect on CysLT1 receptors located in the epithelial tissue of the respiratory tract (LTC4, LTD4, LTE4). Also, the drug prevents the development of bronchospasm, which usually occurs due to the inhalation of cysteinyl leukotriene LTD4.
Preparations of Montelucast eliminate spasm of smooth muscles of blood vessels and bronchioles, relieve edema, slow the migration of macrophages and eosinophils, inhibit the processes of mucus secretion.
After taking the tablets, the substance is quickly and completely absorbed through the digestive tract. Its maximum concentration is observed after 2.5 hours after entering the stomach. The bioavailability of the agent is approximately 65-73%. The degree of binding to proteins is high, at least 99%. The drug undergoes metabolic reactions in the liver with the help of CYP3A4 and CYP2C9 isoenzymes, is excreted in the bile for 2.7-5.5 hours. The plasma clearance is 45 ml per minute.
Usually, in order to stop bronchospasm, a dose of 5 mg is enough. Admission of more than 10 mg of the substance does not improve the effectiveness of treatment. Bronchodilation due to taking the drug comes in 2 hours and remains in the course of the whole day.
In experiments on mice and rats for two years, no systematic oncogenic effects were observed with the systematic administration of animals of this substance. Also, experiments on animals and individual animal cells did not reveal a mutagenic and clastogenic effect of the drug. When taking dosages not exceeding recommended, the drug did not affect the fertility and fertility of individuals of male and female sex.

Indications for use

The medicine is prescribed:
    for the elimination of a runny nose that occurs due to seasonal or permanent allergies;
    as a prophylactic for bronchial asthma;
    with long-term treatment of bronchial asthma, if the patient is allergic to acetylsalicylic acid;
    to prevent night and day symptoms of asthma;
    as a prophylaxis of the disease with increased physical exertion.

Contraindications for Montelucast

The drug is contraindicated:
    when allergic to the active ingredient;
    children up to 2 years.
With caution the preparation is used:
    in children under the age of 6;
    at violations in the work of the liver;
    pregnant women;
    during lactation;
    when combined with certain medicines.

Side effects

The most common side effects of taking pills: indigestion, dizziness, headaches, swelling of the nasal mucosa.
Also, during treatment, the agent may manifest:
    drowsiness, psychomotor agitation, bright dreams and hallucinations, aggression, increased fatigue, disturbances in sleep, paresthesia;
    rarely - convulsions and convulsive seizures, eosinophilic liver infiltrates;
    nausea, diarrhea, pain and discomfort in the abdomen, vomiting;
    Quincke's edema, hives, anaphylactic reactions, itching, rash;
    myalgia and arthralgia;
    a feeling of palpitations, an increased likelihood of bleeding, swelling, bleeding, bruising;
    cough, runny nose, increased level of liver enzymes, influenza state.
During post-marketing research and on the basis of clinical experience of drug use, cases of the following adverse reactions were identified:
    thrombocytopenia, jaundice, hepatitis, impaired liver function;
    depression, thoughts of suicide, suicide attempts, anxiety, tremor;
    pancreatitis, nosebleeds;
    hepatocellular, mixed or cholestatic hepatitis (rarely).
Serious violations in the liver and hepatitis often developed in patients who are predisposed to these kinds of diseases (with alcohol abuse, parallel treatment with other drugs, the presence of other liver diseases, including viral hepatitis).

Montelucast, instructions for use (Method and dosage)

The dosage is set individually, depending on the dosage form used, the age of the patient and the indications.

Instruction for Montelucast

The standard daily dosage is from 4 to 10 mg of the drug, the frequency of administration is 1 time per day. Adults appoint 10 mg of substance before going to bed.
The effect of taking the pill develops during the first day of therapy. It is recommended to continue treatment as a prophylaxis after eliminating the symptoms of exacerbation. The duration of the therapy is established by the attending physician.
Often the drug is used in combination with inhaled glucocorticosteroids or bronchodilators.

Montelucast, instructions for use in children

Children are usually prescribed chewable tablets, with a dosage of 5 mg once a day at night. The course of treatment is determined by the doctor.

Overdose

When taking 200 mg of medication per day for 20 weeks and taking 0.9 grams per day for 7 days, the symptoms of overdose did not appear.
There are reports of the development of acute overdose when taking more than 1 gram of substance during post-marketing research. Symptoms: thirst, dry mouth, drowsiness, nausea and vomiting, headaches, mydriasis, violent psychomotor agitation, painful sensations in the abdomen. Treatment is symptomatic, there are no specific recommendations for an overdose of Montelucast.

Interaction

This substance can be combined with other medicines from bronchial asthma or allergic rhinitis. The drug is well combined with bronchodilators and after achieving the desired effect of therapy, you can gradually reduce their dosage. Therapeutic doses of Montelucast had no effect on the pharmacokinetics of theophylline, prednisolone, oral contraceptives, digoxin, warfarin, terfenadine.
Phenobarbital reduces AUC drugs by about 40%, however, dosage adjustment is not necessary.
In laboratory studies, it was found that this substance inhibits the isoenzyme CYP2C8, but during the study of the pharmacokinetics of the drug in a living body, it turned out that the agent does not have this effect. Therefore, it can be combined with rosiglitazonom, paclitaxel and repaglinide.
The use of the drug in patients who additionally receive inhaled glucocorticosteroids leads to the development of an additional therapeutic effect. After stabilizing the patient's condition, you can gradually reduce the dosage of GCS. With a favorable course, you can gradually completely discontinue inhaled GCS.

Terms of sale

To buy Montelucast you don't need a prescription.

Storage conditions

Tablets are stored in a cool, dark place, inaccessible to small children.
Shelf life - 24 months.

special instructions

The side effects section describes common psychoneurotic disorders associated with the treatment of Montelucast. It is assumed that the listed symptoms could be caused by other factors. If the patient has a listed adverse reactions, this should be reported to his or her treating doctor.
It is not established whether the drug is effective in treating acute attacks of bronchial asthma, the agent does not replace short-acting inhaled beta2-agonists. The patient is recommended to have them with him. During the use of emergency drugs, you must not stop taking Montelucast.
During the drug treatment, patients who have a confirmed allergy to NSAIDs and acetylsalicylic acid should refrain from taking these drugs. Bronchodilator improves respiratory function, but can not completely eliminate bronchoconstriction caused by allergens.
With a decrease in the dosage of systemic glucocorticosteroids due to the initiation of treatment with leukotriene receptor blockers, rash, eosinophilia, neuropathy, heart complications, Chardzha Strauss syndrome, vasculitis sometimes develop. Therefore, it is recommended that special care be taken when reducing dosage of GCS, the patient should be monitored by the attending physician.
It is necessary to inform patients with phenylketonuria that pills contain phenylalanine (aspartame). One chewable tablet contains 4 to 5 mg of aspartame.

Children

Children up to 2 years of age, this substance is contraindicated in receiving. When treating children from 2 to 6 years, it is recommended to use the appropriate dosage form of the drug.

The elderly

Despite the fact that the half-life of the drug from the body in elderly patients is somewhat greater than that of young patients, dosage adjustment is not required. The medicine is well tolerated by patients over the age of 65 and 75 years.

With alcohol

Treatment with the drug is not recommended to combine with the intake of alcohol, especially often or in large doses. This increases the load on the liver.

In pregnancy and lactation

Due to the fact that there have not been adequate clinical studies of the effect of the drug on the baby in pregnant and lactating women, it is not recommended to use it during pregnancy and during lactation. It is necessary to consult with the attending physician.

Reviews Montelucast

Reviews Montelucast in the treatment of children and adults are mostly good. Here are some of them:
    "... My child was prescribed a medicine by an allergist-immunologist from dry, exhausting allergic cough. After several days of treatment, my daughter became better, the symptoms did not completely disappear, but the condition improved significantly, it took much less time to recover from the illness ";
    "... I bought the drug from bronchial asthma. He helped me very well, after the course I literally "came to life", at the beginning of treatment there were side effects, but since time they have passed. "