Singulair tabs 5mg #14

Singulair tablets instruction for use

You can buy Singulair on this page

Composition

The active component is Montelukast.
Additional components of tablets of 4 mg: hydroxypropyl cellulose, mannitol, sodium croscarmellose, aspartame, MCC, iron oxide red, cherry flavor, magnesium stearate.
Pink tablets of 5 mg contain the following excipients: mannitol, iron oxide red, giprolose, aspartame, sodium croscarmellose, cherry flavor, MCC, magnesium stearate.
Coated tablets of 10 mg include such additional components as sodium croscarmellose, MCC, magnesium stearate, lactose, giprolose. The composition of the shell: iron oxide red, iron oxide yellow, giprolose, titanium dioxide, hypromellose, carnauba wax.

Form of issue

Chewable tablets in dosages of 10, 5 and 4 mg.

pharmachologic effect

The blocker of leukotriene receptors. The remedy is used for obstructive airway diseases.

Pharmacodynamics and pharmacokinetics

The active substance of the drug blocks the cysteinyl leukotriene receptors of the airway epithelium. It inhibits bronchospasm caused by leukotriene LTD4, in the case of bronchial asthma.
Causes bronchodilation in a couple of hours after taking.
The drug is rapidly absorbed after ingestion. When taking the usual dosages of 10 mg, the maximum plasma concentration is reached after 3 hours. Bioavailability of 64%. The remedy is safe and effective regardless of meals.
In case of taking 5 mg tablets after ingestion, the maximum concentration is reached after 2 hours. Bioavailability in this case is 73%, it decreases by 10% when applied during meals.
Tablets of 4 mg are indicated for children 2-5 years of age. The maximum concentration is achieved after 2 hours.
About 99% of the active substance binds to plasma proteins. It is actively metabolized. The main enzyme in the metabolism is cytochrome P450 2C8. Participation in the therapeutic effect of metabolites is minimal.
The clearance of the active substance from the plasma is approximately 45 ml / min. Excreted with bile almost completely along with metabolites.

Indications for use of Singulair

Tablets are used for:
    therapy of bronchial asthma in case of hypersensitivity to acetylsalicylic acid;
    prevention and long-term treatment of bronchial asthma;
    prevention of bronchospasm due to heavy physical exertion;
    prevention of asthma in children 2-5 years of age, caused by physical exertion;
    to relieve allergic rhinitis.

Contraindications

Do not take this product with hypersensitivity to its components. Not suitable for children under 2 years.

Side effects

When taking the drug, the following negative side effects may appear:
    allergy: urticaria, anaphylaxis, rash, Quincke's edema, itching;
    digestive system: nausea, indigestion, pain in the abdomen, vomiting, diarrhea;
    nervous system: nightmares, headache, drowsiness, tremor, depression, disorientation, excessive excitation or fatigue, paresthesia, hypoesthesia, hallucinations, increased irritability, aggressive behavior, insomnia, dizziness, lethargy;
    musculoskeletal system: myalgia, arthralgia;
    hepatobiliary system: increased serum transaminase levels, hepatitis;
    Other: increased probability of subcutaneous hemorrhages and increased bleeding, swelling, increased heart rate, thirst, discomfort, fever.
In rare cases, eosinophilic liver infiltrates, susceptibility to suicide and convulsive seizures are possible.
In general, the drug is well tolerated. Side effects, as a rule, do not require the abolition of therapy.

Instructions for the use of the Singulair (Method and dosage)

The use of the drug for children is shown under the supervision of adults.
In the case of allergic rhinitis and asthma, the instruction for Singulair informs you that you need to take 1 tablet 4 mg once a day. In order to facilitate the manifestation of allergic rhinitis, the regimen is selected individually.
In asthma, children 2-5 years of age receive a medication with one chewable tablet of 4 mg every day in the evening.
The therapeutic effect with taking medication is reached within a day. It is recommended to continue to take pills even if asthma control is achieved.
The use of the drug as an alternative to low-dose inhaled corticosteroids for children with persistent asthma of a mild degree is possible only if there have been no recent asthma attacks that required corticosteroids, and if patients can not use inhaled corticosteroids. The patient must be evaluated periodically. If the proper effect is not achieved, you need to consider another or additional anti-inflammatory therapy.
For those who are going to take Singulair tablets, the instruction manual says that they can be added to bronchodilators.
In order to prevent bronchospasm, which is triggered by physical exertion, the patient's condition should be evaluated after 2-4 weeks of use. If there is not enough effect, you need to consider additional or other treatment.
Instructions for the use of the Singulair for adult patients and children from 15 years of age report that they need to take the medicine every day at a dosage of 10 mg 1 time. Children 6-14 years of age are prescribed 5 mg per day.

Overdose

Most reports of an overdose of undesirable manifestations were not observed. Possible adverse reactions that correspond to the safety profile of the drug: drowsiness, pain in the abdomen, thirst, headache, vomiting, psychomotor hyperactivity. Therapy is symptomatic.

Interaction

It is acceptable to prescribe with other means, which are used for the purpose of prevention or long-term treatment of asthma.
With caution, this agent must be administered in conjunction with CYP blockers CY4, 2C9 and 2C8.
The system exposure of Montelukast increases 4.4 times when combined with gemfibrozil. Correction of dosage is not required, but the physician should consider the possibility of adverse reactions.
If treatment with bronchodilators is not effective, you can add Singulair to therapy. When the desired action is achieved, the dose of bronchodilators can be gradually reduced.
The drug also allows to achieve additional therapeutic effect in patients who use inhaled corticosteroids. When the condition stabilizes, the dose of corticosteroids can be reduced. But you need to do this gradually and under the supervision of a specialist. In some cases, you can cancel the reception completely. Sharp replacement therapy is not recommended.

Terms of sale

To buy Singulair you don't need a prescription.

Storage conditions

The medicine should be kept in a dark and dry place. The temperature does not exceed 30 ° С. Make sure that the drug is not available to children.

Shelf life

Tablets in the shell should be stored no longer than three years, for chewing tablets, the shelf life is 2 years. Do not apply at the end of this time.

Singlon or Singulair - which is better?

Singlon is one of the most popular analogues of the Singulair. The latter drug for many has too high a price, so they try to look for substitutes for it. Questions "Singlon or Singulair - which is better?" Can often be found on forums. Those who tried both means write that they did not notice the difference. At the same time, Singlon is twice cheaper.
Doctors report that there is a difference in efficiency and in most cases it is better to take the Singulair, but if it is necessary to replace it, it is advisable to start taking Singlon.

Reviews of Singulair

Reviews about Singulair on the forums are mostly positive. Reports of the occurrence of side effects are extremely rare.
Parents' reviews of Singulair suggest that this is a very effective quick-acting tool that is suitable for children of different ages. It is especially emphasized that the medicine is safe for health. So for those who wonder whether hormone is hormone or not, doctors and those who have applied it in practice unequivocally answer that it is non-hormonal. He, on the contrary, in some cases can replace inhaled corticosteroids, which is especially important if the medicine should be given to children.
The doctors' testimonies testify that this remedy is often prescribed for various respiratory diseases. Specialists and patients believe that the high price of the drug is absolutely justified.