Coldrex MaxGrip powder #10

Coldrex MaxGrip instruction for use

You can buy Coldrex online

Composition

Ascorbic acid, phenylephrine and paracetamol are the main components of the drug.
Additional ingredients: sodium citrate, lemon flavor, sodium saccharinate, silicon dioxide colloid, citric acid, corn starch, sucrose, sodium cyclamate, curcumin dye.

Form of issue

Coldrex MaxGripp is available in the form of a powder.

pharmachologic effect

This drug has antipyretic, vasoconstrictive and analgesic effect, eliminating common cold symptoms.

Pharmacodynamics and pharmacokinetics

The effect of the drug is due to the characteristics of the components that make up its composition.
Paracetamol has antipyretic and analgesic effect. It is quickly absorbed from the digestive tract, and then evenly distributed in the body fluids. The component is biotransformed in the liver to form metabolites. Half-life is 2-3 hours.
Phenylephrine is a vasoconstrictor that helps to get rid of nasal congestion and helps to facilitate breathing. It is poorly absorbed from the digestive tract and excreted in the urine.
Ascorbic acid replenishes the lack of vitamin C. It is well absorbed from the digestive tract. The degree of connection with plasma proteins is 25%. The component is biotransformed in the liver. Excreted through the kidneys.

Indications for use

Coldrex MaxGripp is used to eliminate cold and flu symptoms:
    headache;
    chills;
    elevated temperature;
    nasal congestion;
    painful sensations in the sinuses of the nose;
    pain in the joints and muscles;
    pain in the throat.

Contraindications

Do not use the medicine for negative reactions of the body to its components and in children under 6 years. In addition, the drug is contraindicated in pregnancy, lactation, zakratougolnoy glaucoma, kidney failure, lack of glucose-6-phosphate dehydrogenase, liver failure, malabsorption syndrome, blood diseases, prostate hyperplasia, thyrotoxicosis, diabetes, certain heart diseases, hypertension, as well as in old age.
With caution, the agent should be used with congenital hyperbilirubinemia.

Side effects

Due to a negative reaction to paracetamol, the following side effects may occur:
    rash, angioedema, hives;
    thrombocytopenia, agranulocytosis, and leukopenia.
Side effects due to the use of phenylephrine can be as follows:
    dizziness, headache, insomnia;
    increased pressure, palpitations;
    vomiting, diarrhea.
Negative reactions to ascorbic acid may result in the following effects:
    erythropenia, thrombocytosis, neutrophilic leukocytosis;
    rash, skin hyperemia;
    irritation of the mucosa of the gastrointestinal tract, hypokalemia, hyperprothrombinemia.

Instructions for Use Caldex Maxgripp (Method and Dosage)

Instruction for Coldrex MaxGripp says that the drug should be taken at the first sign of colds. The usual dosage is 1 packet four times a day. The powder must be dissolved in 250 ml of warm water. If desired, a little sugar or honey can be added to the solution.
Instruction for use indicates that the duration of treatment is calculated for a maximum of 5 days.

Overdose

Long-term use of paracetamol in a higher dosage can cause hepatotoxic and nephrotoxic effects. There may be abdominal pain, nausea, pale skin, vomiting.
In addition, a severe overdose can lead to encephalopathy or even to coma and death. In addition to this, kidney necrosis, arrhythmia, pancreatitis can develop due to kidney damage.
In case of overdose, it is necessary to consult a specialist even if there are no unpleasant symptoms. In this situation, therapy is symptomatic. As an antidote, acetylcysteine ​​is used.

Interaction

Coldrex MaxGripp is not allowed in combination with MAO inhibitors, tricyclic antidepressants and beta-blockers. In addition, it is contraindicated within 14 days after their cancellation.
Paracetamol is able to potentiate the effect of indirect anticoagulants, which increases the likelihood of bleeding. In addition, when it is combined with inducers of microsomal oxidation enzymes in the liver, the likelihood of a hepatotoxic effect increases. And inhibitors of microsomal oxidation, on the contrary, reduce the risk of hepatotoxic effect.
With simultaneous use of paracetamol dulls the effect of diuretics.
The rate of absorption of paracetamol is increased by the action of metoclopramide and domperidone, and also decreases under the influence of Kolestyramine.
Paracetamol potentiates the effects of MAO inhibitors, ethanol and sedatives. In addition, the combination of phenylephrine with MAO inhibitors can cause an increase in pressure. It also suppresses the action of beta-blockers and antihypertensive drugs.
The sympathomimetic effect of phenylephrine is enhanced by the effect of tricyclic antidepressants. And when combined with Halothane, ventricular arrhythmia may develop.
Phenylephrine reduces the hypotensive effect of guanethidine, which in turn increases the alpha-adrenostimulating effect of phenylephrine.
Interaction with antidepressants, antipsychotic drugs, antiparkinsonian drugs and phenothiazine derivatives may result in urinary retention, constipation or dry mouth. The combination with GCS increases the risk of glaucoma.

Terms of sale

This medication is sold in the pharmacy network without a doctor's prescription.

Storage conditions

Coldrex MaxGripp is recommended to keep at a temperature of up to 25 ° C in a place inaccessible to small children.

Shelf life

3 years from the date indicated on the package.

Reviews about Coldrex

Opinions about this medication are mostly positive. Those who took the drug, note its effectiveness, pleasant taste and quick action. To the shortcomings of funds, there are numerous contra-indications and a high price.